Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children

2000 ◽  
Vol 68 (5) ◽  
pp. 541-555 ◽  
Author(s):  
H Takahashi
Keyword(s):  
Developmental Changes ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Japanese Children ◽  
Warfarin Enantiomers

scholarly journals The Developmental Changes in Cube Copying Abilities of Japanese Children with Typical Development

2020 ◽  
Vol 4 (2) ◽  
pp. p20
Author(s):  
Takashi Gotoh ◽  
Noriko Haruhara ◽  
Rina Ishii ◽  
Asako Mogami ◽  
Ayumi Matsunaga
Keyword(s):  
Necker Cube ◽  
Developmental Changes ◽  
Typical Development ◽  
Age Group ◽  
Japanese Children ◽  
Copying Task

Purpose: The purpose of this study was to analyze the developmental changes in Necker cube copying and isometric perspective cube copying abilities of Japanese children of typical development.Methods and Results: [Study-1] A total of 40 individuals aged 5-18 years participated in Study-1. The Necker cube copying task was administered, and scores were assigned based on the method developed by Yorimitsu et al. (2013). The results showed that the scores increased significantly for children in the 8-9 years age group (p < 0.01).[Study-2] A total of 32 individuals aged 6-10 years participated in Study-2. The isometric perspective cube copying task was administered, and scores were assigned based on the method developed by Otomo (2009). The results showed that the scores increased significantly for children in the 7-8 years age group (p < 0.05).Conclusions: Japanese children of typical development were able to perform the Necker cube copying task from approximately nine years of age. The same participants were able to perform the isometric perspective cube copying task from approximately eight years of age.

scholarly journals Lack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yani Liu ◽  
Rui Zhang ◽  
Zhongfang Li ◽  
Jiali Zhou ◽  
Tingyu Yang ◽  
...  
Keyword(s):  
Geometric Mean ◽  
International Normalized Ratio ◽  
Healthy Male ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Good Tolerance ◽  
Osteoarthritis Pain ◽  
Dose Warfarin ◽  
Cox 2 ◽  
Pain Symptoms ◽  
Warfarin Enantiomers

Abstract Imrecoxib is a registered treatment for osteoarthritis pain symptoms in China. This study aims to assess the effect of imrecoxib on the pharmacodynamics and pharmacokinetics of warfarin. 12 healthy male volunteers with CYP2C9*3 AA and VKORC1 AA genotypes took a 5 mg dose of warfarin both alone and concomitantly with steady-state imrecoxib. Both warfarin alone and concomitantly with imrecoxib have safey and good tolerance across the trial. Following warfarin and imrecoxib co-administration, neither Cmax, AUC0-t and t1/2 of warfarin enantiomers nor AUC of international normalized ratio (INR) were markedly different from those of warfarin alone. The geometric mean ratios (GMRs) (warfarin + imrecoxib: warfarin alone) of INR(AUC) was 1 (0.99, 1.01). The GMRs of warfarin AUC0-∞ (90% confidence interval, CIs) for warfarin + imrecoxib: warfarin alone were 1.12 (1.08, 1.16) for R-warfarin and 1.13 (1.07, 1.18) for S- warfarin. The 90% CIs of the GMRs of AUC0-∞, Cmax and INR (AUC) were all within a 0.8–1.25 interval. The combination of warfarin and imrecoxib did not impact the pharmacodynamics and pharmacokinetics of single-dose warfarin; therefore, when treating a patient with imrecoxib and warfarin, it is not required to adjust the dosage of warfarin.

Developmental Study of Causal Attributions and Judgments of Achievement by Japanese Children

1988 ◽  
Vol 62 (2) ◽  
pp. 507-517 ◽  
Author(s):  
Hirotsugu Yamauchi
Keyword(s):  
Causal Attributions ◽  
Developmental Changes ◽  
Developmental Study ◽  
Japanese Children ◽  
Evaluative Feedback

This article has two purposes, developmental changes of causal schemata are examined and developmental shifts in judgments of achievement are tested. The developmental changes of causal schemata are measured by two methods. (1) Extent of an effect is inferred from the facilitative causes and (2) the degrees of a facilitative cause are inferred from an effect and another facilitative cause. Developmental shifts of causal schemata ate noted among children in Grades 2, 4, and 6. Judgments of achievement are measured by asking subjects to provide “evaluative feedback” to an hypothetical school pupil's grade. The judgments of achievement are affected by the perceived expenditure of effort, independent of performance on the examination.

scholarly journals Developmental Changes in Pharmacokinetics and Pharmacodynamics

2018 ◽  
Vol 58 ◽  
pp. S10-S25 ◽  
Author(s):  
John van den Anker ◽  
Michael D. Reed ◽  
Karel Allegaert ◽  
Gregory L. Kearns
Keyword(s):  
Developmental Changes ◽  
Pharmacokinetics And Pharmacodynamics

Developmental Changes of Aldehyde Oxidase Activity in Young Japanese Children

2007 ◽  
Vol 81 (4) ◽  
pp. 567-572 ◽  
Author(s):  
Y Tayama ◽  
K Miyake ◽  
K Sugihara ◽  
S Kitamura ◽  
M Kobayashi ◽  
...  
Keyword(s):  
Oxidase Activity ◽  
Aldehyde Oxidase ◽  
Developmental Changes ◽  
Japanese Children

Development of Reactions to Pain of Inoculation in Children and their Mothers

1999 ◽  
Vol 23 (3) ◽  
pp. 731-746 ◽  
Author(s):  
Koichi Negayama
Keyword(s):  
Facial Expressions ◽  
Child Behaviour ◽  
Developmental Changes ◽  
Naturalistic Study ◽  
Older Children ◽  
Japanese Children ◽  
Per Se ◽  
Children's Pain ◽  
Old Females ◽  
Immediate Reactions

This is a naturalistic study focusing on developmental changes in the immediate reactions of 183 Japanese children under 7 years old and their mothers to pain caused by inoculation of the children. Under the age of 5 crying was a typical child behaviour, whereas 5- and 6-year-olds showed facial expressions instead. Their mothers were generally empathetic to the children’s distress on inoculation, but the empathetic reactions tended to decrease as the children grew older. However, children’s crying per se did not necessarily cause the reactions, and the mothers of the older children tended to react to the children’s pain with a smile. A greater proportion of 3-year-old females cried than males of the same age, but despite this their mothers had a stronger tendency to respond with a smile in comparison with the mothers of male children. The results were discussed with respect to development of emotional independence and competence of social manipulation by children.

Spherulitic crystal growth in the prodissoconch larval of Crassostrea virginica

1983 ◽  
Vol 41 ◽  
pp. 518-519
Author(s):  
George G. Cocks ◽  
Louis Leibovitz ◽  
DoSuk D. Lee
Keyword(s):  
Crystal Structure ◽  
Crassostrea Virginica ◽  
Crystal Orientation ◽  
Developmental Changes ◽  
Gastrula Stage ◽  
Orthorhombic Crystal ◽  
Orthorhombic Crystal Structure ◽  
Stages Of Growth ◽  
Early Stages ◽  
Initial Deposition

Our understanding of the structure and the formation of inorganic minerals in the bivalve shells has been considerably advanced by the use of electron microscope. However, very little is known about the ultrastructure of valves in the larval stage of the oysters. The present study examines the developmental changes which occur between the time of conception to the early stages of Dissoconch in the Crassostrea virginica(Gmelin), focusing on the initial deposition of inorganic crystals by the oysters.The spawning was induced by elevating the temperature of the seawater where the adult oysters were conditioned. The eggs and sperm were collected separately, then immediately mixed for the fertilizations to occur. Fertilized animals were kept in the incubator where various stages of development were stopped and observed. The detailed analysis of the early stages of growth showed that CaCO3 crystals(aragonite), with orthorhombic crystal structure, are deposited as early as gastrula stage(Figuresla-b). The next stage in development, the prodissoconch, revealed that the crystal orientation is in the form of spherulites.

Pharmacokinetics and pharmacodynamics of meperidine in healthy horses

2020 ◽  
Vol 47 (6) ◽  
pp. 855.e11-855.e12
Author(s):  
H. Trenholme ◽  
A. Hanafi ◽  
R. Reed ◽  
D. Sakai ◽  
C. Ryan ◽  
...  
Keyword(s):  
Pharmacokinetics And Pharmacodynamics
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