Determination of gamma radiation sterilization dose of nano-chitosan/cellulose microbial composite for splinting periodontal

2021 ◽  
Author(s):  
Darmawan Darwis ◽  
Farah Nurlidar ◽  
Basril Abbas ◽  
Yessy Warastuti ◽  
Fajar Lukitowati ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
Radiation Sterilization ◽  
Radiation Sterilization Dose ◽  
Sterilization Dose

scholarly journals Radiation Dose Audit Failures: Truth and Consequences

2020 ◽  
Vol 54 (s1) ◽  
pp. 64-72
Author(s):  
Trabue Bryans ◽  
Lisa Foster ◽  
Kimberly Patton ◽  
Joyce M. Hansen
Keyword(s):  
Radiation Dose ◽  
Radiation Sterilization ◽  
Dose Determination ◽  
Incorrect Assumption ◽  
Radiation Sterilization Dose ◽  
Sterilization Dose

Abstract The validation of a radiation sterilization dose involves an initial sterilization dose determination as well as maintenance of that sterilization dose. The procedures for maintenance of the sterilization dose typically include the periodic use of two types of tests: bioburden and dose audits. The details for the procedures are outlined in the ISO radiation sterilization standards. These documents also provide guidelines for recommended actions in response to the results of the two tests. The results for the dose audit are based on the number of positive tests of sterility (TOS) for products that have been irradiated at a verification or experimental dose. When the dose audit yields TOS positives, it is often thought that they indicate a sterilization failure and nonsterile product. The belief that any TOS positive is a failure is an incorrect assumption because of the statistical basis used for the determination of the sterilization dose. This article will outline the truth of what dose audit TOS positives mean in terms of the sterility assurance of product, as well as the consequences of TOS positives.

Reducing the radiation sterilization dose improves mechanical and biological quality while retaining sterility assurance levels of bone allografts

Bone ◽  
2013 ◽  
Vol 57 (1) ◽  
pp. 194-200 ◽  
Author(s):  
Huynh Nguyen ◽  
Alan I. Cassady ◽  
Michael B. Bennett ◽  
Evelyne Gineyts ◽  
Andy Wu ◽  
...  
Keyword(s):  
Radiation Sterilization ◽  
Biological Quality ◽  
Bone Allografts ◽  
Radiation Sterilization Dose ◽  
Sterilization Dose

scholarly journals Validation Of Radiation Sterilization Dose For Proteases Immobilized On Aldehyde-Containing Textile Carriers

2014 ◽  
Vol 4 (10) ◽  
pp. 63-68
Author(s):  
Svetla Maksimova Dyankova ◽  
Maria Doncheva Doneva ◽  
Tsvetan Dimitrov Tsvetkov
Keyword(s):  
Radiation Sterilization ◽  
Radiation Sterilization Dose ◽  
Sterilization Dose

scholarly journals Effects of Radiation sterilization Dose on the Molecular Weight and Gelling Properties of Commercial Alginate Samples

2021 ◽  
Vol 8 ◽  
Author(s):  
M. Z. I. Mollah ◽  
M S. Rahaman ◽  
M R I. Faruque ◽  
M U. Khandaker ◽  
Hamid Osman ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Average Molecular Weight ◽  
Reduction Rate ◽  
Gel Permeation Chromatography ◽  
Radiation Sterilization ◽  
Gelling Properties ◽  
Effects Of Radiation ◽  
Radiation Sterilization Dose ◽  
Sterilization Dose ◽  
Mass Recovery

To estimate the molecular weight (Mw) and gelling properties, a total of 26 alginate samples consisting of control (n = 13) and 15 kGy γ-irradiated (n = 13) samples were characterized through viscometric and gel permeation chromatography (GPC-MALLS) methods. Based on the observations, a remarkable decrease in the intrinsic viscosity of all samples of alginates was evident due to the effects of radiation, with a linear relationship between viscosity and concentration in 0.01 M NaCl solution. The correlation among the Mw, percentage mass recovery, radii of gyration (Rz/Rg), and percentage reduction of Mw assessed by GPC was significant. The Mw decreased dramatically (from 3.1 × 105 to 0.49 × 105 mole/g in sample no. 12) by the effect of radiation with momentous relation to the % reduction of the molecular weight. The highest molecular weight reduction (84%), which is the most sensitive to γ-radiation, and the average reduction rate was ≥50%. The mass recovery was 100% obtained from samples no. 1,3,4,5,7,12, and 13, while the rest of the samples’ recovery rate was significantly higher. The reduction rate of mass molecular weight (Mw) is higher than the average molecular weight (Mv), but they showed a sensitivity towards radiation, consequently their performance are different from each other. The stability test was performed as a critical behaviour in the control, recurrently same as in the irradiated samples. Thus, the sterilization dose of 15 kGy for the Mw distribution, and subsequently for the characterization, was significantly effective.

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