Relationship of macrophage migration inhibitory factor level and -173 G/C single nucleotide polymorphism with rheumatoid arthritis

2022 ◽  
Author(s):  
Ali Razzaq Hussein ◽  
Nawfal Hussein Aldujaili ◽  
Fatima Abdul Hussein Mejbel
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Nucleotide Polymorphism ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Macrophage Migration ◽  
Nucleotide Polymorphism ◽  
Factor Level ◽  
Single Nucleotide ◽  
Migration Inhibitory Factor Level ◽  
Relationship Of

scholarly journals Single-nucleotide polymorphism and haplotype analysis of macrophage migration inhibitory factor gene and its correlation with serum macrophage migration inhibitory factor levels in North Indian psoriatic patients with moderate disease severity: A cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-7
Author(s):  
Seema Chhabra ◽  
Nirmalya Banerjee ◽  
Tarun Narang ◽  
Swati Sood ◽  
Anuradha Bishnoi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Migration Inhibitory Factor ◽  
Gene Polymorphisms ◽  
Macrophage Migration Inhibitory Factor ◽  
Disease Susceptibility ◽  
Age At Onset ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Background: Psoriasis is associated with significant morbidity and impaired quality of life. Identification of the host genes that influence disease susceptibility and can potentially guide future, targeted therapy is the need of the hour. Aims: The aim of the study was to investigate the associations of macrophage migration inhibitory factor (MIF) gene polymorphisms, that is, a 5–8-CATT tetra nucleotide repeats at -794 (-794*CATT5–8) and a single-nucleotide polymorphism at -173 (-173*G/C) with the risk of chronic plaque psoriasis and to observe the correlation, if any, of disease determinants with genetic functional variants and circulating MIF levels. Methods: Five hundred and seventeen individuals (265 psoriasis patients and 252 controls) were genotyped for MIF gene polymorphisms. Data were analyzed with respect to disease susceptibility, serum MIF levels, disease severity, age at onset, disease duration and presence of comorbidities. Results: The presence of co-morbidities was more frequently noted in patients with late onset disease (P = 0.01). No statistically significant differences were observed either in genotype (P = 0.680) or allele frequency (P = 0.69) with respect to distribution of MIF-173*G/C polymorphism between patients and controls. The frequencies of genotypes -794*CATT 5/7 and 7/7 were significantly lower in patients (P = 0.027* and 0.038*, respectively). CATT*5/MIF-173*C haplotype occurred at a higher frequency in patients (odds ratio 3.03, 95% confidence intervals 1.09–8.47, P = 0.02). The mean serum MIF levels were significantly higher in patients as compared to controls (P < 0.001). The presence of either extended MIF -794*CATT repeats or C allele did not reveal any significant association with serum MIF levels or age at onset. Analysis of effect of various disease determinants revealed no significant association with genetic variants and serum MIF levels. Limitations: The lesional expression of MIF could not be studied. Conclusion: Our results showed that CATT*5/MIF-173*C haplotype is associated with increased susceptibility to psoriasis vulgaris.

scholarly journals Estimation of the level of macrophage migration inhibitory factor in patients with coronary artery disease in the presence of some risk factors

2020 ◽  
Vol 24 (3) ◽  
pp. 376-385
Author(s):  
Feyan Abdullah ◽  
Ruqaya Al-Barzinj
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Density Lipoprotein ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Factor Level ◽  
Migration Inhibitory Factor Level ◽  
Artery Disease

Background and objective: Coronary artery disease is a chronic inflammatory disease in which many risk factors and inflammatory mediators, including macrophage migration inhibitory factor, are involved. This study aimed to estimate macrophage migration inhibitory factor level in coronary artery disease patients in regard to age, gender, and smoking. Methods: A total of 138 coronary artery disease patients and 38 coronary artery disease free control subjects were admitted to surgical specialty hospital-cardiac center in Erbil city, Iraq between January and December 2017. Plasma macrophage migration inhibitory factor concentration was measured by enzyme linked immunosorbent assay. Results: Patients and controls were categorized into subgroups according to age (<55 and ≥55 years), gender (women and men), and smoking status (smokers and non-smokers). Macrophage migration inhibitory factor level in every coronary artery disease subgroup (age, gender, and smokers) patients increased significantly compared to the same control subgroups (P <0.05). Macrophage migration inhibitory factor level showed a higher level in coronary artery disease patients subgroups (≥55 years, female, smokers) compared to their corresponding coronary artery disease subgroups (<55 years, male, and non smokers). Macrophage migration inhibitory factor demonstrated a significant positive correlation with fibrinogen and high sensitivity C-reactive protein, insignificant positive correlation with age, total cholesterol, low density lipoprotein, and insignificant negative correlation with high density lipoprotein-cholesterol (P >0.05). Conclusion: This study demonstrated the diagnostic value of macrophage migration inhibitory factor elevation in coronary artery disease patients if compared with coronary artery disease free subjects, meanwhile suggesting that age, gender, and smoking had no direct role in macrophage migration inhibitory factor elevation considering their secondary minor contributions in macrophage migration inhibitory factor circulation. Keywords: Coronary; Macrophage; Age; Gender; Smoking.

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