scholarly journals Quantification of brain tumor metabolites in magnetic resonance spectroscopy using singular value decomposition

2021 ◽  
Author(s):  
E. Asdiantoro ◽  
H. Siswanto ◽  
A. D. Sensusiati ◽  
Y. Dwihapsari
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Singular Value Decomposition ◽  
Magnetic Resonance Spectroscopy ◽  
Singular Value ◽  
Resonance Spectroscopy ◽  
Value Decomposition

scholarly journals Coil Combination of Multichannel Single Voxel Magnetic Resonance Spectroscopy with Repeatedly Sampled In Vivo Data

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3896
Author(s):  
Wanqi Hu ◽  
Huiting Liu ◽  
Dicheng Chen ◽  
Tianyu Qiu ◽  
Hongwei Sun ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Singular Value Decomposition ◽  
Magnetic Resonance Spectroscopy ◽  
Generalized Least Squares ◽  
Singular Value ◽  
Combination Method ◽  
Resonance Spectroscopy ◽  
Sensitivity Matrix ◽  
Value Decomposition

Magnetic resonance spectroscopy (MRS), as a noninvasive method for molecular structure determination and metabolite detection, has grown into a significant tool in clinical applications. However, the relatively low signal-to-noise ratio (SNR) limits its further development. Although the multichannel coil and repeated sampling are commonly used to alleviate this problem, there is still potential room for promotion. One possible improvement way is combining these two acquisition methods so that the complementary of them can be well utilized. In this paper, a novel coil-combination method, average smoothing singular value decomposition, is proposed to further improve the SNR by introducing repeatedly sampled signals into multichannel coil combination. Specifically, the sensitivity matrix of each sampling was pretreated by whitened singular value decomposition (WSVD), then the smoothing was performed along the repeated samplings’ dimension. By comparing with three existing popular methods, Brown, WSVD, and generalized least squares, the proposed method showed better performance in one phantom and 20 in vivo spectra.

BIOM-10. PRECLINICAL PLATFORM FOR THE IDENTIFICATION OF DEUTERIUM MAGNETIC RESONANCE SPECTROSCOPY-BASED BIOMARKERS OF BRAIN TUMOR METABOLISM

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi12-vi12
Author(s):  
Georgios Batsios ◽  
Meryssa Tran ◽  
Céline Taglang ◽  
Anne Marie Gillespie ◽  
Sabrina Ronen ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumors ◽  
Treatment Response ◽  
Lactate Production ◽  
Cell Suspensions ◽  
Response To Therapy ◽  
Resonance Spectroscopy

Abstract Metabolic reprogramming is a fundamental hallmark of cancer, which can be exploited for non-invasive tumor imaging. Deuterium magnetic resonance spectroscopy (2H-MRS) recently emerged as a novel, translational method of interrogating flux from 2H-labeled substrates to metabolic products. However, to date, preclinical studies have been performed in vivo, an endeavor which suffers from low-throughput and potential wastage of animal life, especially when considering studies of treatment response. Developing in vitro assays for monitoring metabolism of 2H-labeled substrates will enhance throughput, lead to the rapid evaluation of new 2H-based probes and enable identification of treatment response biomarkers, thereby allowing the best 2H-based probes to be translated for further in vivo assessment. The goal of this study was to develop a preclinical cell-based platform for quantifying metabolism of 2H-labeled probes in brain tumor models. Since the Warburg effect, which is characterized by elevated glycolytic production of lactate, is a metabolic phenotype of cancer, including brain tumors, we examined metabolism of 2H-glucose or 2H-pyruvate in patient-derived glioblastoma (GBM6) and oligodendroglioma (BT88) cells and compared to normal human astrocytes (NHACONTROL). Following incubation in media containing [6,6’-2H]glucose or [U-2H]pyruvate, 2H-MR spectra obtained from live cell suspensions showed elevated 2H-lactate production in GBM6 and BT88 cells relative to NHACONTROL. Importantly, 2H-lactate production from [6,6’-2H]glucose or from [U-2H]pyruvate was reduced in GBM6 or BT88 cells subjected to irradiation and temozolomide, which is standard of care for glioma patients, pointing to the utility of this method for detecting response to therapy. Collectively, we have, for the first time, demonstrated the ability to quantify metabolism of 2H-MRS probes in live cell suspensions and validated the utility of our assay for differentiating tumor from normal cells and assessing response to therapy. Our studies will expedite the identification of novel 2H-MRS probes for imaging brain tumors and potentially other types of cancer.

Denoising of 3D magnetic resonance images by using higher-order singular value decomposition

2015 ◽  
Vol 19 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Xinyuan Zhang ◽  
Zhongbiao Xu ◽  
Nan Jia ◽  
Wei Yang ◽  
Qianjin Feng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Singular Value Decomposition ◽  
Magnetic Resonance Images ◽  
Higher Order ◽  
Singular Value ◽  
Value Decomposition

A clinical and magnetic resonance spectroscopy study of a brain tumor in a patient with segmental neurofibromatosis

2010 ◽  
Vol 56 (4) ◽  
pp. 297-302 ◽  
Author(s):  
S. Chebel ◽  
S. Ben Yahia ◽  
A. Boughammoura-Bouatay ◽  
R. Salem ◽  
M. Golli ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
Magnetic Resonance Spectroscopy Study
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