Negative correlation between lifespan of mammalian erythrocytes and sodium-potassium ions membrane permeability coefficients

2021 ◽  
Author(s):  
Atanas Todorov Atanasov
Keyword(s):  
Membrane Permeability ◽  
Negative Correlation ◽  
Potassium Ions ◽  
Sodium Potassium ◽  
Permeability Coefficients

scholarly journals Changes in the Membrane Permeability of Frog's Sartorius Muscle Fibers in Ca-Free EDTA Solution

1963 ◽  
Vol 47 (2) ◽  
pp. 379-392 ◽  
Author(s):  
H. Kimizuka ◽  
K. Koketsu
Keyword(s):  
Membrane Permeability ◽  
Chloride Content ◽  
Chloride Ions ◽  
Sartorius Muscle ◽  
Constant Field ◽  
Sodium Influx ◽  
Sodium Potassium ◽  
Edta Solution ◽  
Frog Sartorius ◽  
Sodium And Potassium

The changes in the membrane permeability to sodium, potassium, and chloride ions as well as the changes in the intracellular concentration of these ions were studied on frog sartorius muscles in Ca-free EDTA solution. It was found that the rate constants for potassium and chloride efflux became almost constant within 10 minutes in the absence of external calcium ions, that for potassium increasing to 1.5 to 2 times normal and that for chloride decreasing about one-half. The sodium influx in Ca-free EDTA solution, between 30 and 40 minutes, was about 4 times that in Ringer's solution. The intracellular sodium and potassium contents did not change appreciably but the intracellular chloride content had increased to about 4 times normal after 40 minutes. By applying the constant field theory to these results, it was concluded that (a) PCl did not change appreciably whereas PK decreased to a level that, in the interval between 10 and 40 minutes, was about one-half normal, (b) PNa increased until between 30 and 40 minutes it was about 8 times normal. The low value of the membrane potential between 30 and 40 minutes was explained in terms of the changes in the membrane permeability and the intracellular ion concentrations. The mechanism for membrane depolarization in this solution was briefly discussed.

Membrane permeability of isolated lung cells to nonelectrolytes at different temperatures

1982 ◽  
Vol 243 (5) ◽  
pp. C285-C292 ◽  
Author(s):  
R. A. Garrick ◽  
F. P. Chinard
Keyword(s):  
Membrane Permeability ◽  
Tritiated Water ◽  
Cellular Systems ◽  
Lung Cells ◽  
Cell Preparation ◽  
Rabbit Lung ◽  
Novikoff Hepatoma ◽  
Permeability Coefficients ◽  
Diffusional Permeability ◽  
Isolated Lung

Membrane permeability coefficients (P0) of rabbit lung cells consisting primarily of alveolar epithelial and endothelial cells and of alveolar macrophages from dog lungs were determined for tritiated water, n-[14C]alcohols, and [14C]antipyrine over the temperature range 10 to 37 degrees C with the series-parallel pathway model. In the mixed cell preparation both the diffusional permeability to water (755 X 10(-5) cm.s-1 at 37 degrees C) and the response to temperature change (apparent activation energy, Ea, 10 kcal.mol-1) are greater than the corresponding values in the macrophages (110 X 10(-5) cm.s-1 and 4.8 kcal.mol-1, respectively). The permeability coefficients for the small alcohols (C1-C3) are similar and considerably higher than for water in both cellular preparations. The values of the permeability coefficients and the temperature dependence for antipyrine and the larger alcohols in the mixed lung cells differ from the values obtained in the macrophages. Comparison of our results with those obtained in erythrocytes and Novikoff hepatoma cells demonstrates the differences in water permeability in each cell preparation and the similarity in permeation for the more lipophilic solutes in the cell preparations. These differences may be important in the comparison of results obtained in isolated cellular systems and in intact tissues and organs.

Sodium permeability and myocardial resistance to cell swelling during metabolic blockade

1980 ◽  
Vol 239 (1) ◽  
pp. H31-H39 ◽  
Author(s):  
M. B. Pine ◽  
D. Kahne ◽  
B. Jaski ◽  
C. S. Apstein ◽  
K. Thorp ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Renal Cortex ◽  
Cell Volume Regulation ◽  
Cell Membrane Permeability ◽  
Cell Swelling ◽  
Monovalent Cations ◽  
Sodium Potassium ◽  
Produce Cell ◽  
Potassium Exchange

The role of cell membrane permeability to sodium in cell volume regulation during inhibition of the sodium-potassium exchange pump with ouabain and during total metabolic blockade was evaluated in sections of guinea pig renal cortex, ventricle, and atrium incubated in Krebs-Henseleit solution. In all tissues, 2 and 3 h of ouabain and metabolic blockade resulted in similar marked losses of potassium and parallel continuous reductions in resting membrane potentials. Only metabolic blockade of renal cortex increased cell water, chloride, and total monovalent cations (potassium plus sodium) significantly. Compared to ouabain, metabolic blockade markedly increased the rate of cellular washout of 24Na+ from renal cortex (t 1/2 reduced by 47%), which was significantly greater than reductions in t 1/2 from ventricle (16%) and atrium (15%). Thus, inhibition of sodium-potassium exchange pump activity was not sufficient to produce cell swelling unless associated with marked increases in cell membrane permeability to sodium, in which case sodium influx exceeded potassium loss and substantial increases in monovalent cations, chloride, and water occurred.

The Determination of Membrane Permeability Coefficients of Canine Pancreatic Islet Cells and Their Application to Islet Cryopreservation

Cryobiology ◽  
1997 ◽  
Vol 35 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Jun Liu ◽  
Michael A.J. Zieger ◽  
Jonathan RT Lakey ◽  
Erik J. Woods ◽  
John K. Critser
Keyword(s):  
Membrane Permeability ◽  
Pancreatic Islet ◽  
Islet Cells ◽  
Pancreatic Islet Cells ◽  
Permeability Coefficients

scholarly journals Strongly Coupled 2D Transition Metal Chalcogenide-MXene-Carbonaceous Nanoribbon Heterostructures with Ultrafast Ion Transport for Boosting Sodium/Potassium Ions Storage

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Junming Cao ◽  
Junzhi Li ◽  
Dongdong Li ◽  
Zeyu Yuan ◽  
Yuming Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Ion Transport ◽  
Density Functional ◽  
2D Materials ◽  
High Rate ◽  
Potassium Ions ◽  
List Type ◽  
Sodium Potassium ◽  
Metal Chalcogenide ◽  
Strongly Coupled

Highlights Unique “Janus” interfacial assemble strategy of 2D MXene nanosheets was proposed firstly. Ternary heterostructure consisting of high capacity transitional metal chalcogenide, high conductive 2D MXene and N rich fungal carbonaceous matrix was achieved for larger radius Na/K ions storages. The highly accessible surfaces and interfaces of the strongly coupled 2D based ternary heterostructures provide superb surficial pseudocapacitive storages for both Na and K ions with low energy barriers was verified. Abstract Combining with the advantages of two-dimensional (2D) nanomaterials, MXenes have shown great potential in next generation rechargeable batteries. Similar with other 2D materials, MXenes generally suffer severe self-agglomeration, low capacity, and unsatisfied durability, particularly for larger sodium/potassium ions, compromising their practical values. In this work, a novel ternary heterostructure self-assembled from transition metal selenides (MSe, M = Cu, Ni, and Co), MXene nanosheets and N-rich carbonaceous nanoribbons (CNRibs) with ultrafast ion transport properties is designed for sluggish sodium-ion (SIB) and potassium-ion (PIB) batteries. Benefiting from the diverse chemical characteristics, the positively charged MSe anchored onto the electronegative hydroxy (–OH) functionalized MXene surfaces through electrostatic adsorption, while the fungal-derived CNRibs bonded with the other side of MXene through amino bridging and hydrogen bonds. This unique MXene-based heterostructure prevents the restacking of 2D materials, increases the intrinsic conductivity, and most importantly, provides ultrafast interfacial ion transport pathways and extra surficial and interfacial storage sites, and thus, boosts the high-rate storage performances in SIB and PIB applications. Both the quantitatively kinetic analysis and the density functional theory (DFT) calculations revealed that the interfacial ion transport is several orders higher than that of the pristine MXenes, which delivered much enhanced Na+ (536.3 mAh g−1@ 0.1 A g−1) and K+ (305.6 mAh g−1@ 1.0 A g−1 ) storage capabilities and excellent long-term cycling stability. Therefore, this work provides new insights into 2D materials engineering and low-cost, but kinetically sluggish post-Li batteries.

Lithium inhibits morphogenesis of the nervous system but not neuronal differentiation in Xenopus laevis

Development ◽  
1987 ◽  
Vol 99 (3) ◽  
pp. 353-370 ◽  
Author(s):  
L.J. Breckenridge ◽  
R.L. Warren ◽  
A.E. Warner
Keyword(s):  
Neural Differentiation ◽  
Lithium Treatment ◽  
Neural Induction ◽  
Potassium Ions ◽  
Blastula Stage ◽  
Cell Stage ◽  
Bathing Medium ◽  
Sodium Potassium ◽  
Developmental Defects ◽  
Cell Type Specific

Xenopus embryos treated with 100 mM-lithium from the 2- to 4-cell stage to the early blastula stage (4h) failed to neurulate and developed without a discernible anteroposterior axis. The internal structure of defective embryos was grossly disorganized, but immunohistochemical staining with cell-type-specific antibodies revealed differentiated nerve and muscle cells. Quantitative assay in tissue cultures from control and acutely abnormal lithium-treated embryos showed that neural differentiation was enhanced and muscle differentiation unaffected. The embryos took up about 0.5 mM-lithium at threshold, maximal effects resulted at 2–3 mM. Most of the lithium was extruded from the cells into the blastocoel fluid, where lithium reached 17 mM. The threshold intracellular concentration was about 150 microM. Lithium uptake rose steeply as the osmotic/ionic strength of the bathing medium increased. Sodium, potassium and lithium were equally able to increase the permeability of the embryo. However, sodium ions enhanced, while potassium ions interfered with, the uptake of lithium. Treatment with lithium at progressively later stages reduced the developmental defects and neural differentiation returned to normal levels. The uptake of lithium did not decline concomitantly. We conclude that lithium does not inhibit neural induction, but interferes with dorsal patterning. The sensitivity of the embryo to lithium is determined by developmental stage. The very low, effective intracellular concentrations may be important in understanding the mechanism of lithium-generated defects.

Sign in / Sign up

Export Citation Format

Share Document