Noninvasive diagnostics of heart rate variability in patients with undifferentiated connective tissue dysplasia

2020 ◽  
Author(s):  
A. V. Akimova ◽  
V. A. Mironov ◽  
T. F. Mironova ◽  
A. I. Milashchenko
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Connective Tissue ◽  
Noninvasive Diagnostics ◽  
Connective Tissue Dysplasia

scholarly journals Assessment of heart rate variability and tone of the autonomic nervous system in puberty-aged children with undifferentiated connective tissue dysplasia

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
O V Sidorovich ◽  
S Y U Elizarova ◽  
A V Khizhnyak ◽  
N A Kuznetsova ◽  
E E Prosova
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Connective Tissue ◽  
Control Group ◽  
Healthy Children ◽  
Autonomic Nervous ◽  
Connective Tissue Dysplasia ◽  
End Of Puberty

Abstract   Within the framework of the research into pathological conditions and syndromes associated with undifferentiated connective tissue dysplasia (UCTD), an emphasis needs to be placed on the changes in heart rhythm. In puberty, the severity of neurovegetative disorders caused by the presence of UCTD might increase manifold. The features of heart rate variability (HRV) in pubertal children against the background of UCTD have been studied insufficiently and require more detailed analysis. This study aims to assess heart rate variability and tone of the autonomic nervous system (ANS) in puberty-aged children with UCTD. Two groups of children were examined, with methods including electrocardiography and cardiointervalography. The main group consisted of 36 puberty-aged children with UCTD, the control group consisted of 30 healthy children. ANS tone was assessed based on the HRV. In the control group of children aged 11, the value of variation range (VR) was 0.18±0.4, mode amplitude (MA) 35.2±2.4, stress index (IN) 72.8±4.3, which corresponds to the state of vegetative balance. As the puberty progresses, the state of eutonia is replaced by the activation of the sympathetic division of the ANS, which becomes most pronounced at the age of 13 years. In the control group of children aged 13, the value of VR was 0.08±0.02, MA 61.7±2.1, SI 210.6±8.6, which corresponds to moderate sympathicotonia. By the end of puberty, in healthy children, the severity of sympathetic activation begins to decrease, and at the age of 15 years, vegetative balance is again observed. However, this pattern is violated in children with UCTD. Upon entering puberty, moderate activation of the sympathetic division of the ANS is already observed in children with UCTD. At the age of 11 years in this group, the value of VR is 0.06±0.02, MA 72.4±3.1, SI 211.2±8.6. At the age of 13, pronounced sympathicotonia is observed, which is confirmed by the values of VR - 0.04±0.01, MA 80.2±4.3 and SI 34.3±14.7. By the end of puberty in children with UCTD, in contrast to the control group, the analyzed parameters indicate not an equilibrium of the ANS, but the predominance of parasympathetic activation. The research provides an insight into heart rate variability in puberty-aged children with UCTD. It was established that healthy children enter puberty in a state of equilibrium of the autonomic nervous system, which in the middle of puberty is replaced by moderate sympathicotonia, and then returns to its original values. Children with the presence of UCTD enter puberty with moderately pronounced sympathicotonia, which gradually increases to pronounced values and is replaced by moderate vagotonia. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Opportunities of ivabradine to reduce heart rate before CT coronary angiography in young patients with connective tissue dysplasia

2014 ◽  
Vol 5 (1) ◽  
pp. 50-55
Author(s):  
I. V Druk ◽  
G. I Nechayeva ◽  
Yu. T Ignatyev ◽  
S. I Aksenov ◽  
N. I Orlova
Keyword(s):  
Computed Tomography ◽  
Heart Rate ◽  
Coronary Angiography ◽  
Connective Tissue ◽  
Young Patients ◽  
Ct Coronary Angiography ◽  
Efficacy And Safety ◽  
Reduce Heart Rate ◽  
Connective Tissue Dysplasia ◽  
Group 1

To assess the efficacy and safety application ivabradine to control the heart rate before the procedure computed tomography coronary angiography (CTCA) in young patients with connective tissue dysplasia (CTD) were surveyed 65 patients (age 24,9±6,4 years; 40 men). Patients were divided into 2 groups: group 1 (n=47; 29 men) to achieve the heart rate

scholarly journals AB0160 CARDIAC AUTONOMIC NEUROPATHY PREVALENCE IN A COHORT OF SYSTEMIC SCLEROSIS (SSC) PATIENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1380.2-1381
Author(s):  
F. Masini ◽  
R. Galiero ◽  
P. C. Pafundi ◽  
E. Pinotti ◽  
K. Gjeloshi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Autonomic Neuropathy ◽  
Autonomic Dysfunction ◽  
Cardiac Autonomic Neuropathy ◽  
Heart Rate Variability Analysis ◽  
Study Population ◽  
Duration Of Disease

Background:Systemic sclerosis is a rare disease determining a damage to the connective tissue and, consequently, an involvement of several organs. Besides the damage of the connective tissue, preminent is also the small vessels injury, detectable by videocapillaroscopy. Some authors report that the vascular damage may be also responsible of a cardiovascular impairment as cardiac autonomic disease (CAN) and heart rate variability [1].Objectives:Our study aims to assess the presence and entity of CAN in patients with systemic sclerosis (SSc).Methods:This is a pilot prospective cohort study. We enrolled 28 patients in a period of six months, from May 2019 to November 2019, afferent to the outpatient clinic of internal medicine and immunology of the Primo Policlinico of Naples, with definite SSc diagnosis in absence of other comorbidities. All patients underwent diagnostic tests for autonomic cardiac neuropathy (NAC) and videocapillaroscopy. In particular, four test were performed to search for the presence of NAC: orthostatic hypotension, deep breathing, lying to standing and Valsalva maneuver. Each test was corrected for age and diagnosis was made in the case at least two tests resulted positive. Primary endpoint of the study was the assessment of the prevalence of autonomic cardiac neuropathy in the study population.Results:Our cohort was mainly characterized by females (92.9%), with a median age of 58.5 years [IQR: 49-64.8 yrs.] and a median duration of the disease of 4 years [IQR 2-13 yrs.]. The observed prevalence of NAC was equal to the 46.4% (13 cases). In addition, we evaluated the potential association of NAC with age, duration of disease, gastrointestinal dysmotility, sicca syndrome, cutaneous involvement and type of videocapillaroscopy pattern, from which no statistically significant result emerged. Hence, a further analysis, by using a time-dependent Cox regression model (with the duration of disease as time covariate), was performed on the same variables. From this model a significant association emerged in particular between the presence of NAC and the active videocapillaroscopy pattern (OR 6.23; 95% CI: 1.058-36.71, p=0.043).Conclusion:Though current data in the literature on this topic are poor, cardiac autonomic neuropathy is among the clinical manifestations of SSc. In our study population, though the limited sample size, we observed a high percentage of patients with autonomic cardiac neuropathy, which seems much more frequent with the increase in the duration of disease and based on the type of videocapillaroscopy pattern.References:[1]Ferri C, Emdin M, Giuggioli D, Carpeggiani C, Maielli M, Varga A, Michelassi C, Pasero G, L’Abbate A. Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis. Br J Rheumatol. 1997[2]Adler BL, Russell JW, Hummers LK, McMahan ZH. Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire. J Rheumatol. 2018 Aug;45(8):1145-1152. doi: 10.3899/jrheum.170868. Epub 2018 JunDisclosure of Interests:None declared

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