Complex increase in reliability and durability of the aerospace equipment based on thermoemission cooling of hot elements

2021 ◽  
Author(s):  
Alexey V. Kolychev ◽  
Vladimir A. Kernozhitsky ◽  
Pavel A. Arkhipov ◽  
Artem M. Fedorov
Keyword(s):  
Complex Increase

Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

2010 ◽  
Vol 63 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Elina Turunen ◽  
Janne Mannila ◽  
Riikka Laitinen ◽  
Joakim Riikonen ◽  
Vesa-Pekka Lehto ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Cyclodextrin Complex ◽  
Complex Increase

scholarly journals Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Jyothsna Visweswaraiah ◽  
Alan G Hinnebusch
Keyword(s):  
Ternary Complex ◽  
Start Codon ◽  
Exit Channel ◽  
Initiation Complex ◽  
Channel Protein ◽  
Codon Recognition ◽  
Closed State ◽  
Complex Increase

The eukaryotic pre-initiation complex (PIC) bearing the eIF2·GTP·Met-tRNAiMet ternary complex (TC) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes rearrangement of the PIC from an open, scanning to a closed, arrested conformation. Cryo-EM reconstructions of yeast PICs suggest remodeling of the interface between 40S protein Rps5/uS7 and eIF2α between open and closed states; however, its importance was unknown. uS7 substitutions disrupting eIF2α contacts favored in the open complex increase initiation at suboptimal sites, and uS7-S223D stabilizes TC binding to PICs reconstituted with a UUG start codon, indicating inappropriate rearrangement to the closed state. Conversely, uS7-D215 substitutions, perturbing uS7-eIF2α interaction in the closed state, confer the opposite phenotypes of hyperaccuracy and (for D215L) accelerated TC dissociation from reconstituted PICs. Thus, remodeling of the uS7/eIF2α interface appears to stabilize first the open, and then the closed state of the PIC to promote accurate AUG selection in vivo.

The Analysis of the Impact of the Chosen Factors on the Orthotics Progress in the Distal Parts of the Limbs in Adults

Physiotherapy ◽  
2013 ◽  
Vol 21 (3) ◽  
Author(s):  
Zofia Nowicka ◽  
Karolina Więckowska ◽  
Zdzisława Wrzosek
Keyword(s):  
Diabetes Mellitus ◽  
Technological Progress ◽  
Neurological Diseases ◽  
Vascular Diseases ◽  
Science Research ◽  
Research Teams ◽  
Number Of Factors ◽  
Functional Efficiency ◽  
The Impact ◽  
Complex Increase

AbstractThe orthotics is one of the means of impact in rehabilitation and it determines the functional efficiency of the patient [1]. To be able to achieve that aim it must change constantly. Progress in this area is determined by a number of factors including: technological progress, increasing number of injuries, sometimes very complex, increase in diseases of affluence (vascular diseases, cancer, neurological diseases, osteoporosis, diabetes mellitus), where orthoses may be applied during the treatment, interdisciplinarity manifested in the creation of science research teams, increasing expectations of the patients for the equipment improvement in a functional and cosmetic aspect.

Complex increase in safety of space flights by thermoemission cooling of elements of aerospace equipment

2021 ◽  
Author(s):  
Alexey V. Kolychev ◽  
Vladimir A. Kernozhitsky ◽  
Vitaly A. Savelov ◽  
Artem M. Fedorov
Keyword(s):  
Space Flights ◽  
Complex Increase

scholarly journals Life complex increase of all groups of compressor blades of a turbo-shaft gas turbine engine on the basis of a functionally-directed approach

2017 ◽  
Vol 2 (9) ◽  
pp. 42-48 ◽  
Author(s):  
Александр Михайлов ◽  
Alexander Mikhailov ◽  
А. Байков ◽  
A. Baykov ◽  
В. Михайлов ◽  
...  
Keyword(s):  
Gas Turbine ◽  
Gas Turbine Engine ◽  
Compressor Blade ◽  
Erosion Wear ◽  
Compressor Blades ◽  
Turbine Engine ◽  
Complex Increase

The analysis of peculiarities in compressor blade operation of the turbo-shaft gas turbine engine is carried out. At the same time the compressor blade structuring into groups is carried and it is shown that structural groups of blades operate under different conditions of operation. It is defined, that different structural groups of compressor blades have their own definite peculiarities of operation and erosion wear. It is shown, that the erosion wear of all groups of compressor blades may be characterized by irregularities of three kinds. In the paper a general approach to life increase of all groups of compressor blades in a helicopter gas turbine engine is offered.

scholarly journals Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

PLoS Genetics ◽  
2019 ◽  
Vol 15 (12) ◽  
pp. e1008494 ◽  
Author(s):  
Malgorzata Jedrychowska ◽  
Milena Denkiewicz-Kruk ◽  
Malgorzata Alabrudzinska ◽  
Adrianna Skoneczna ◽  
Piotr Jonczyk ◽  
...  
Keyword(s):  
Repetitive Sequences ◽  
Complex Increase ◽  
Dependent Mechanism

scholarly journals Role of gelsolin interaction with actin in regulation and creation of actin nuclei in chemotactic peptide activated polymorphonuclear neutrophils.

1992 ◽  
Vol 3 (12) ◽  
pp. 1427-1435 ◽  
Author(s):  
J D Deaton ◽  
T Guerrero ◽  
T H Howard
Keyword(s):  
Actin Polymerization ◽  
Polymorphonuclear Neutrophils ◽  
Initial Increase ◽  
Actin Assembly ◽  
Chemotactic Peptide ◽  
Activated Platelets ◽  
Formyl Peptide ◽  
Complex Increase

In vitro Ca++ activates gelsolin to sever F-actin and form a gelsolin-actin (GA) complex at the+end of F-actin that is not dissociated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) but is separated by EGTA+PIP/PIP2. The gelsolin blocks the+end on the actin filament, but the-end of the filament can still initiate actin polymerization. In thrombin activated platelets, evidence suggests that severing of F-actin by gelsolin increases GA complex, creates one-end actin nucleus and one cryptic+end actin nucleus per cut, and then dissociates to yield free+ends to nucleate rapid actin assembly. We examined the role of F-actin severing in creation and regulation of nuclei and polymerization in polymorphonuclear neutrophils (PMNs). At 2-s intervals after formyl peptide (FMLP) activation of endotoxin free (ETF) PMNs, change in GA complex was correlated with change in+end actin nuclei,-end actin nuclei, and F-actin content. GA complex was quantitated by electrophoretograms of proteins absorbed by antigelsolin from cells lysed in 10 mM EGTA,+end actin nuclei as cytochalasin (CD) sensitive and-end actin nuclei as CD insensitive increases in G-pyrenyl actin polymerization rates induced by the same PMNs, and F-actin content by NBDphallacidin binding to fixed cells. Thirty three percent of gelsolin was in GA complex in basal ETF PMNs; from 2-6 s, GA complexes dissociate (low = 15% at 10 s) and sequentially+end nuclei and F-actin content and then-end nuclei increase to a maximum at 10 s. At > s GA complex increase toward basal and + end nuclei and F-actin content returned toward basal. These kinetic data show gelsolin regulates availability of + end nuclei and actin polymerization in FMLP. However, absence of an initial increase in GA complex or - end nucleating activity shows FMLP activation does not cause gelsolin to sever F- or to bind G-actin to create cryptic + end nuclei in PMNs; the results suggest the + nucleus formation is gelsolin independent.

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