scholarly journals Imaging of surface acoustic waves on GaAs using 2D confocal Raman microscopy and atomic force microscopy

2021 ◽  
Vol 118 (3) ◽  
pp. 031602
Author(s):  
Brian Douglas Rummel ◽  
Leonid Miroshnik ◽  
Marios Patriotis ◽  
Andrew Li ◽  
Talid R. Sinno ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Acoustic Waves ◽  
Surface Acoustic Waves ◽  
Raman Microscopy ◽  
Confocal Raman Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Confocal Raman

scholarly journals Real-Time Drug Release Imaging From Nanocomposite Drug and Polymer Coatings

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Jinping Dong ◽  
Greg Haugstad ◽  
Chris Frethem ◽  
John Foley ◽  
Bob Hoerr ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Polymer Coatings ◽  
Raman Microscopy ◽  
Prolonged Release ◽  
Confocal Raman Microscopy ◽  
Release Process ◽  
Force Microscopy ◽  
Confocal Raman ◽  
Model Drug

The ElectroNanospray process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. A model drug delivery system consisting of a polymer matrix (arborescent polyisobutylene-polystyrene, or arbIBS) and either dexamethasone or sirolimus was studied by various characterization techniques. Modification of ElectroNanospray process parameters resulted in surface coatings with rich morphologies that are revealed by SEM, Atomic Force Microscopy (AFM) and Confocal Raman Microscopy were employed to monitor the drug release process in situ, through which the mechanism of the drug-eluting process may be proposed. A Confocal Raman microscope fitted with underwater objective was used to image arbIBS∕drug films incubated in phosphate-buffered saline over 12h and at various film depths. Drug migrated from more concentrated areas into the surrounding polymer and toward the surface, beginning as early as 5min after placing the sample in buffer and continuing throughout the 12h period. High drug levels remained in the more concentrated areas at the end of incubation, suggesting the potential for prolonged release. SEM and AFM images taken from samples post incubation showed the appearance of nanoscale pores ∼100nm in diameter in areas corresponding in size and distribution to the Confocal Raman planar image areas of increased drug concentration. Confocal Raman microscopy offers a powerful new technique for demonstrating real-time drug release from therapeutic medical device coatings.

Probing Chemical and Physical Properties of Poplar Tension Wood Using Confocal Raman Microscopy and Pulsed Force Mode Atomic Force Microscopy

MRS Advances ◽  
2017 ◽  
Vol 2 (19-20) ◽  
pp. 1103-1109
Author(s):  
Mikhael Soliman ◽  
Laurene Tetard
Keyword(s):  
Atomic Force Microscopy ◽  
Cell Wall ◽  
Plant Cell Wall ◽  
Cellulose Content ◽  
Force Microscopy ◽  
Atomic Force ◽  
Fundamental Understanding ◽  
Force Mode ◽  
Confocal Raman ◽  
Mode Atomic Force Microscopy

ABSTRACTLignocellulosic biofuels have been identified as a possible solution to contribute to the world’s demands in energy and environmental sustainability. However, the fundamental understanding of the physical and chemical traits hindering key reactions during biomass to biofuel conversion processes has been limited by the lack of suitable tools and by the large natural variability in such systems. Reaction wood constitutes a good model system to study variations of cellulose content, given the increase in cellulose content in the cell walls of the region under tension in the plant during growth. In this work, we use confocal Raman mapping and Pulsed Force Mode Atomic Force Microscopy (PFM) to explore the effect of variation in cellulose content on the structure and composition of the plant cell wall at the nanoscale. Using statistical analysis on Raman datasets, the characteristic peaks for cellulose and lignin are examined to reveal changes in peak positions across the different scanned regions of the cross section. PFM is used to study local mechanical properties of the different layers of the cell wall. Our approach facilitates the correlation of structure-composition traits of the plant cell wall for a more fundamental understanding of processes involved in biofuel research.

ZnO Based SAW Delay Line: Thin Film Characteristics and IDT Fabrication

2003 ◽  
Vol 785 ◽  
Author(s):  
Farid Hassani ◽  
Shahrokh Ahmadi ◽  
Can E. Korman ◽  
Mona Zaghloul ◽  
Shiva Hullavarad ◽  
...  
Keyword(s):  
Acoustic Waves ◽  
Delay Line ◽  
Surface Acoustic Waves ◽  
Rf Sputtering ◽  
Device Fabrication ◽  
Zno Films ◽  
X Ray Diffraction ◽  
Force Microscopy ◽  
Atomic Force ◽  
Interdigital Electrodes

AbstractZnO, a well-known piezoelectric material, is used to develop micro-scale Surface Acoustic Wave (SAW) delay line sensor. In this work, SAW delay line Devices are fabricated employing ZnO films that are deposited by RF sputtering technique. Films are characterized prior to device fabrication by X-Ray Diffraction (XRD) for film crystalline quality, UV-visible transmission spectroscopy for optical characteristics, and Atomic Force Microscopy (AFM) for surface morphology. Interdigital electrodes producing surface acoustic waves in the hundreds of MHz are developed by photolithography and metalization techniques. SAW delay line device testing, measurement and characteristics on RF sputtered ZnO films are presented and compared.

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