The missing role of hydrodynamic stresses on ascending aortic dissection

2021 ◽  
Vol 33 (1) ◽  
pp. 011901
Author(s):  
Marina G. Karachaliou ◽  
Gerasimos A. T. Messaris ◽  
Vassilios C. Loukopoulos ◽  
Constantinos M. Koutsojannis ◽  
Petros E. Zampakis ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Hydrodynamic Stresses

scholarly journals Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Peiru Liu ◽  
Jing Zhang ◽  
Duo Du ◽  
Dandan Zhang ◽  
Zelin Jin ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Aortic Dissection ◽  
Epigenetic Regulation ◽  
Heart Development ◽  
Type A ◽  
Methylation Pattern ◽  
Healthy Controls ◽  
Global Methylation ◽  
Thoracic Aortic Dissection

Abstract Background Thoracic aortic dissection (TAD) is a severe disease with limited understandings in its pathogenesis. Altered DNA methylation has been revealed to be involved in many diseases etiology. Few studies have examined the role of DNA methylation in the development of TAD. This study explored alterations of the DNA methylation landscape in TAD and examined the potential role of cell-free DNA (cfDNA) methylation as a biomarker in TAD diagnosis. Results Ascending aortic tissues from TAD patients (Stanford type A; n = 6) and healthy controls (n = 6) were first examined via whole-genome bisulfite sequencing (WGBS). While no obvious global methylation shift was observed, numerous differentially methylated regions (DMRs) were identified, with associated genes enriched in the areas of vasculature and heart development. We further confirmed the methylation and expression changes in homeobox (Hox) clusters with 10 independent samples using bisulfite pyrosequencing and quantitative real-time PCR (qPCR). Among these, HOXA5, HOXB6 and HOXC6 were significantly down-regulated in TAD samples relative to controls. To evaluate cfDNA methylation pattern as a biomarker in TAD diagnosis, cfDNA from TAD patients (Stanford type A; n = 7) and healthy controls (n = 4) were examined by WGBS. A prediction model was built using DMRs identified previously from aortic tissues on methylation data from cfDNA. Both high sensitivity (86%) and specificity (75%) were achieved in patient classification (AUC = 0.96). Conclusions These findings showed an altered epigenetic regulation in TAD patients. This altered epigenetic regulation and subsequent altered expression of genes associated with vasculature and heart development, such as Hox family genes, may contribute to the loss of aortic integrity and TAD pathogenesis. Additionally, the cfDNA methylation in TAD was highly disease specific, which can be used as a non-invasive biomarker for disease prediction.

scholarly journals Role of Transesophageal Echocardiography in Patients With Suspected Aortic Dissection

2005 ◽  
Vol 18 (11) ◽  
pp. 1221.e5-1221.e7 ◽  
Author(s):  
H ELTZSCHIG ◽  
P ROSENBERGER ◽  
R LEKOWSKIJR ◽  
J SCOTT ◽  
A LOCKE ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Transesophageal Echocardiography

The role of medical treatment of distal type aortic dissection

1991 ◽  
Vol 32 (2) ◽  
pp. 231-240 ◽  
Author(s):  
Kazuhiro Hara ◽  
Tetsu Yamaguchi ◽  
Yasuhiko Wanibuchi ◽  
Kiyoshi Kurokawa
Keyword(s):  
Aortic Dissection ◽  
Medical Treatment

Abstract 18391: Accumulation of Adiponectin in Association With Up-regulated T-cadherin in the Aortic Wall of Acute and Chronic Aortic Dissection

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yoshiki Watanabe ◽  
Shigeru Miyagawa ◽  
Satsuki Fukushima ◽  
Norikazu Maeda ◽  
Atsuhiro Saito ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Western Blot ◽  
Blood Concentration ◽  
Aortic Wall ◽  
Acute Type ◽  
Type B ◽  
Rt Pcr ◽  
Multiple Organs ◽  
Aortic Media

Introduction: Adiponectin (APN) is a major adipokine, which has been reported to accumulate into the damaged tissues in multiple organs. However, the role of APN and its receptor, T-cadherin (T-cad), in the pathology of the human aortic wall (AW) is poorly understood. In this study, we examined the distributions of APN and T-cad in the dissected AW and measured the serum APN concentration in patients with aortic dissection (AD). Methods: Diseased AW tissues were collected from patients with acute or chronic AD at the time of surgery, and a healthy aorta was used as a control (n = 6 per group). Blood was serially sampled to measure the APN concentrations in non-surgically-treated patients with acute type B AD (n = 10). Results: Immunohistochemically, normal aortic walls weakly expressed APN or T-cad on the intimal surface, whereas the AWs of acute AD patients showed marked expression of both APN and T-cad on the surface of the dissected aortic media. In chronic AD, APN and T-cad were diffusely expressed on the medial layers of the thickened AW (Fig. A-C). Western blot analysis showed that APN expression in the AW was significantly greater in acute and chronic AD than in the normal aorta (151 ± 2% and 220 ± 27% vs. normal, respectively) (Fig. D). RT-PCR revealed no expression of APN mRNA in any AW, and stronger expression of T-cad mRNA in acute and chronic AD than in the normal aorta (108 ± 9% and 194 ± 101% vs. normal, respectively). The blood concentration of APN in type B AD patients decreased by 13.3 ± 3.8% in 24-78 hours, and by 22.7 ± 7.2% in over 78 hours, as compared to those monitored within 24 hours after the onset, indicating that APN was supplied to the affected aortic wall from the blood. Conclusions: APN markedly accumulated into the dissected aortic media in acute and chronic AD, and T-cad was upregulated in the corresponding area. In contrast, the blood concentration of APN reciprocally decreased after AD onset, indicating a possibility of APN contribution to protect a diseased aortic wall of AD.

scholarly journals The Role of Macrophages in Aortic Dissection

2020 ◽  
Vol 11 ◽  
Author(s):  
Xinhao Wang ◽  
Hongpeng Zhang ◽  
Long Cao ◽  
Yuan He ◽  
Airong Ma ◽  
...  
Keyword(s):  
Aortic Dissection

Prognostic role of transesophageal echocardiography in acute type A aortic dissection

2007 ◽  
Vol 153 (6) ◽  
pp. 1013-1020 ◽  
Author(s):  
Eduardo Bossone ◽  
Arturo Evangelista ◽  
Eric Isselbacher ◽  
Santi Trimarchi ◽  
Stuart Hutchison ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Transesophageal Echocardiography ◽  
Type A ◽  
Acute Type ◽  
Prognostic Role ◽  
Type A Aortic Dissection

The role of preoperative coronary angiography in the setting of type A acute aortic dissection: Insights from the International Registry of Acute Aortic Dissection

2011 ◽  
Vol 161 (4) ◽  
pp. 790-796.e1 ◽  
Author(s):  
Vijay S. Ramanath ◽  
Kim A. Eagle ◽  
Christoph A. Nienaber ◽  
Eric M. Isselbacher ◽  
James B. Froehlich ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Type A ◽  
International Registry
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