Evaluation of anti-oxidant and anti-inflammatory activity in leaf and flower ethanolic extracts of Nyctanthes arbor-tristis Linn.

2020 ◽  
Author(s):  
K. B. Soubhagya ◽  
M. Anilkumar
Keyword(s):  
Inflammatory Activity ◽  
Ethanolic Extracts ◽  
Anti Oxidant ◽  
Anti Inflammatory

Sageretia thea Inhibits Inflammation through Suppression of NF-κB and MAPK and Activation of Nrf2/HO-1 Signaling Pathways in RAW264.7 Cells

2019 ◽  
Vol 47 (02) ◽  
pp. 385-403 ◽  
Author(s):  
Ha Na Kim ◽  
Gwang Hun Park ◽  
Su Bin Park ◽  
Jeong Dong Kim ◽  
Hyun Ji Eo ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Mapk Signaling ◽  
Inflammatory Activity ◽  
Nuclear Accumulation ◽  
Raw264.7 Cells ◽  
No Production ◽  
Immunodeficiency Virus ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Signaling Activation

Sageretia thea (S. thea) commonly known as Chinese sweet plum or Chinese bird plum has been used for treating hepatitis and fevers in Korea and China. S. thea has been reported to exert anti-oxidant, anticancer and anti-human immunodeficiency virus activity. However, there is little study on the anti-inflammatory activity of S. thea. Thus, we evaluated the anti-inflammatory effect of extracts of leaves (ST-L) and branches (ST-B) from Sageretia thea in LPS-stimulated RAW264.7 cells. ST-L and ST-B significantly inhibited the production of the pro-inflammatory mediators such as NO, iNOS, COX-2, IL-1[Formula: see text] and IL-6 in LPS-stimulated RAW264.7 cells. ST-L and ST-B blocked LPS-induced degradation of I[Formula: see text]B-[Formula: see text] and nuclear accumulation of p65, which resulted in the inhibition of NF-[Formula: see text]B activation in RAW264.7 cells. ST-L and ST-B also attenuated the phosphorylation of ERK1/2, p38 and JNK in LPS-stimulated RAW264.7 cells. In addition, ST-L and ST-B increased HO-1 expression in RAW264.7 cells, and the inhibition of HO-1 by ZnPP reduced the inhibitory effect of ST-L and ST-B against LPS-induced NO production in RAW264.7 cells. Inhibition of p38 activation and ROS elimination attenuated HO-1 expression by ST-L and ST-B, and ROS elimination inhibited p38 activation induced by ST-L and ST-B. ST-L and ST-B dramatically induced nuclear accumulation of Nrf2, but this was significantly reversed by the inhibition of p38 activation and ROS elimination. Collectively, our results suggest that ST-L and ST-B exerts potential anti-inflammatory activity by suppressing NF-[Formula: see text]B and MAPK signaling activation, and activating HO-1 expression through the nuclear accumulation of Nrf2 via ROS-dependent p38 activation. These findings suggest that ST-L and ST-B may have great potential for the development of anti-inflammatory drug to treat acute and chronic inflammatory disorders.

scholarly journals Study on Anti-oxidant and Anti-inflammatory Activity of the Tissue-cultured Shoot Clumps from Raoulia australis

2014 ◽  
Vol 40 (4) ◽  
pp. 349-357
Author(s):  
Chang-Min Park ◽  
Na-Kyeong Han ◽  
Min-Seok Joung ◽  
Kee-Yoeup Paek ◽  
Jong-Wan Choi
Keyword(s):  
Inflammatory Activity ◽  
Anti Oxidant ◽  
Anti Inflammatory

In vitro anti-oxidant and in vivo anti-inflammatory activity determination of the methanolic leaves extract of Millettiapachycarpa

2015 ◽  
Vol 2 (10) ◽  
Author(s):  
Shofiul Azam ◽  
Prawej Ansari ◽  
Mohammad Mamun Ur Rashid ◽  
Mohammad Nazmul Alam ◽  
Ismail Hussein Ahmed ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Activity Determination ◽  
Anti Oxidant ◽  
Anti Inflammatory

ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF MANNIOPHYTON FULVUM

2005 ◽  
pp. 97-101 ◽  
Author(s):  
R. Nia ◽  
D.H. Paper ◽  
G. Franz ◽  
E.E. Essien ◽  
M. Muganza ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Oxidant ◽  
Anti Inflammatory
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