scholarly journals Interactions at engineered graft–tissue interfaces: A review

2020 ◽  
Vol 4 (3) ◽  
pp. 031502
Author(s):  
Wenzhen Zhu ◽  
Xiaolei Nie ◽  
Qi Tao ◽  
Hang Yao ◽  
Dong-An Wang
Keyword(s):  
Graft Tissue ◽  
Tissue Interfaces

Complex interactions at graft-tissue interfaces reviewed

Scilight ◽  
2020 ◽  
Vol 2020 (34) ◽  
pp. 341107
Author(s):  
Savannah Mandel
Keyword(s):  
Complex Interactions ◽  
Graft Tissue ◽  
Tissue Interfaces

scholarly journals Pericyte Seeded Dual Peptide Scaffold with Improved Endothelialization for Vascular Graft Tissue Engineering

2016 ◽  
Vol 5 (23) ◽  
pp. 3046-3055 ◽  
Author(s):  
Paola Campagnolo ◽  
Adam J. Gormley ◽  
Lesley W. Chow ◽  
Anne Géraldine Guex ◽  
Paresh A. Parmar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Graft ◽  
Graft Tissue

scholarly journals A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156341 ◽  
Author(s):  
Vinay V. Abhyankar ◽  
Meiye Wu ◽  
Chung-Yan Koh ◽  
Anson V. Hatch
Keyword(s):  
Easy Access ◽  
Tissue Interfaces

Heterogeneity and neurovascular integration of intraportally transplanted islets revealed by 3-D mouse liver histology

2021 ◽  
Author(s):  
Chien-Chia Chen ◽  
Shih-Jung Peng ◽  
Pei-Yu Wu ◽  
Hung-Jen Chien ◽  
Chih-Yuan Lee ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Mouse Liver ◽  
Image Data ◽  
Liver Histology ◽  
Systematic Assessment ◽  
3 Dimensional ◽  
Neural Integration ◽  
Quantitative Analyses ◽  
Graft Tissue

Background: Intraportal islet transplantation has been clinically applied for treatment of unstable type 1 diabetes. However, in the liver, systematic assessment of the dispersed islet grafts and the graft-hepatic integration remains difficult, even in animal models. This is due to the lack of global and in-depth analyses of the transplanted islets and their microenvironment. Here, we apply 3-dimensional (3-D) mouse liver histology to investigate the islet graft microstructure, vasculature, and innervation. Methods: Streptozotocin-induced diabetic mice were used in syngeneic intraportal islet transplantation to achieve euglycemia. Optically cleared livers were prepared to enable 3-D morphological and quantitative analyses of the engrafted islets. Results: 3-D image data reveal the clot- and plaque-like islet grafts in the liver: the former are derived from islet emboli and associated with ischemia, whereas the latter (minority) resemble the plaques on the walls of portal vessels (e.g., at the bifurcation) with mild, if any, peri-graft tissue damage. Three weeks after transplantation, both types of grafts are revascularized, yet significantly more lymphatics are associated with the plaque- than clot-like grafts. Regarding the islet reinnervation, both types of grafts connect to the peri-portal nerve plexus and develop peri- and intra-graft innervation. Specifically, the sympathetic axons and varicosities contact the α-cells, highlighting the graft-host neural integration. Conclusion/interpretation: We present the heterogeneity of the intraportally transplanted islets and the graft-host neurovascular integration in mice. Our work provides the technical and morphological foundation for future high-definitional 3-D tissue and cellular analyses of human islet grafts in the liver.

New surgical technique reduces the susceptibility artefact at air–tissue interfaces on in vivo cerebral MRI in the Göttingen minipig

2009 ◽  
Vol 80 (6) ◽  
pp. 403-407 ◽  
Author(s):  
Frederikke Rosendal ◽  
Jesper Frandsen ◽  
M. Mallar Chakravarty ◽  
Carsten Reidies Bjarkam ◽  
Michael Pedersen ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Göttingen Minipig ◽  
Cerebral Mri ◽  
Susceptibility Artefact ◽  
New Surgical Technique ◽  
Tissue Interfaces

scholarly journals APPLICATION OF OZONE THERAPY IN THE TREATMENT OF DENTAL IMPLANTATION COMPLICATIONS

2020 ◽  
Vol 74 (2) ◽  
pp. 77-80
Author(s):  
D.V. Mikhalchenko ◽  
◽  
H.Yu. Salyamov ◽  
Yu.A. Makedonova ◽  
A.V. Mikhalchenko ◽  
...  
Keyword(s):  
Standard Treatment ◽  
Ozone Treatment ◽  
Traditional Treatment ◽  
Dental Implantation ◽  
Positive Tendency ◽  
Graft Tissue ◽  
Pathological Focus ◽  
Implant Treatment ◽  
Single Approach ◽  
Standard Treatment Regimen

The percentage of implant treatment failures is steadily increasing. This may be due to both General and local factors that lead to the development of parotid tissue inflammation. In this case, one of the signs of development postprostatectomy complications following dental implantation is bleeding, redness. Earlier detection of inflammatory phenomena of peri-graft tissue may contribute to the preservation of the tooth and the chewing function of the dentition. Currently, there is no single approach to the treatment of perimplantitis and mucositis. Traditional treatment is based on the use of anti-inflammatory gels and ointments. In this paper, a comparative analysis of the effectiveness of ozone treatment relative to the standard treatment regimen is performed. During 14 days, an examination and instrumental examination were performed to determine the hygienic indices, the bleeding index, the Svrakov iodine number, and periodontal screening. The implant stability coefficient was determined using the Osstel Mentor device. In all groups, there was a positive tendency to subside inflammatory phenomena,and in some cases, there was a complete cessation of the process, but the nature and timing were different depending on the methods of exposure to the pathological focus.

scholarly journals Multichannel 3D plotting for complex tissue equivalents and implants for defects at tissue interfaces

2016 ◽  
Vol 4 ◽  
Author(s):  
Gelinsky Michael ◽  
Akkineni Ashwini ◽  
Sch�tz Kathleen ◽  
Ahlfeld Tilman ◽  
F�rster Yvonne ◽  
...  
Keyword(s):  
Tissue Equivalents ◽  
Tissue Interfaces

scholarly journals A Novel Model for Encephalomyosynangiosis Surgery after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

2021 ◽  
Author(s):  
Mitch Paro ◽  
Daylin Gamiotea Turro ◽  
Leslie Blumenfeld ◽  
Ketan R Bulsara ◽  
Rajkumar Verma
Keyword(s):  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Therapeutic Option ◽  
Treatment Options ◽  
Artery Occlusion ◽  
Novel Treatment ◽  
Graft Tissue ◽  
Cerebral Artery Occlusion

Background and Purpose: No effective treatment is available for most patients who suffer ischemic stroke. Development of novel treatment options is imperative. The brain attempts to self-heal after ischemic stroke via various mechanism mediated by restored blood circulation in affected region of brain but this process is limited by inadequate angiogenesis or neoangiogenesis. Encephalomyosynangiosis (EMS) is a neurosurgical procedure that achieves angiogenesis with low morbidity in patients with moyamoya disease, reducing risk of stroke. However, EMS, surgery has never been studied as an therapeutic option after ischemic stroke. Here we described a novel procedure and feasibility data for EMS after ischemic stroke in mice. Methods: A 60 mins of middle cerebral artery occlusion (MCAo) was used to induce ischemic stroke in mice. After 3-4 hours of MCAo onset/sham, EMS was performed. Mortality of EMS, MCAo and. MCAo+EMS mice was recorded up to 21 days after surgery. Graft tissue viability was measured using a nicotinamide adenine dinucleotide reduced tetrazolium reductase assay. Results: EMS surgery after ischemic stroke does not increase mortality compared to stroke alone. Graft muscle tissue remained viable 21 days after surgery. Conclusions: This novel protocol is effective and well-tolerated, may serve as novel platform for new angiogenesis and thus recovery after ischemic stroke. If successful in mice, EMS can a very feasible and novel treatment option for ischemic stroke in humans.

Buccal mucosal graft urethroplasty in male cats with traumatic complete urethral rupture

2022 ◽  
pp. 1-7
Author(s):  
Wanchart Yippaditr ◽  
Antja Watanangura ◽  
Disdanai Pencharee ◽  
Nobuo Sasaki
Keyword(s):  
Quality Of Life ◽  
Buccal Mucosa ◽  
Abdominal Cavity ◽  
Positive Contrast ◽  
Successful Outcome ◽  
Indwelling Catheter ◽  
Buccal Mucosal Graft ◽  
Graft Tissue ◽  
Urethral Rupture

Abstract OBJECTIVE To evaluate the feasibility of buccal mucosal graft urethroplasty for repairing complete urethral rupture in cats. ANIMALS 15 male domestic shorthair cats with traumatic complete urethral rupture. PROCEDURES In each cat, a section of buccal mucosa was harvested, sutured, and formed into a tubule by use of an 8F indwelling catheter as support. This tubular graft was connected to both ruptured ends of the urethra to renew the urinary passage. The catheter was left in place until the absence of leakage was confirmed by positive contrast retrograde urethrography. After spontaneous urination was confirmed, cats were discharged from the hospital. Six months later, urethrography was repeated and owners were asked to score their cats’ urinary function and quality of life. RESULTS 13 cats recovered well following surgery, with no complications in the oral cavity or surgical site and no signs of difficulty or discomfort when urinating. Urethrography 2 weeks and 6 months after surgery revealed no stricture or leakage in the abdominal cavity. The 2 remaining cats developed a urethral stricture and underwent second surgery with a successful outcome. At the 6-month follow-up, 14 cats had only mild urinary signs, and 1 cat had incontinency. Owners indicated they were delighted (n = 14) or pleased (1) with their cats’ quality of life. CLINICAL RELEVANCE Buccal mucosa was found to be a good source of graft tissue for performance of urethroplasty in male cats, yielding satisfactory outcomes with few postoperative complications. The described technique may be suitable for severe and complicated cases of urethral rupture in male cats.

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