scholarly journals Parkinson’s disease subtype classification: Application of decision tree, logistic regression and logit leaf model

2020 ◽  
Author(s):  
A. Nurrohman ◽  
S. Abdullah ◽  
H. Murfi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Decision Tree ◽  
Subtype Classification ◽  
Disease Subtype ◽  
Leaf Model

Predictors of Pharyngeal Dysphagia in Patients with Parkinson’s Disease

2020 ◽  
Vol 10 (4) ◽  
pp. 1727-1735
Author(s):  
Inga Claus ◽  
Paul Muhle ◽  
Judith Suttrup ◽  
Bendix Labeit ◽  
Sonja Suntrup-Krueger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Rating Scale ◽  
Equivalent Dose ◽  
Binary Logistic Regression Analysis ◽  
Screening Methods ◽  
Clinical Predictors ◽  
Pharyngeal Dysphagia ◽  
Increased Risk

Background: Diagnosis of pharyngeal dysphagia in patients with Parkinson’s disease is often difficult as reliable screening methods are lacking so far and clinical examination fails to adequately assess the pharyngeal phase of swallowing. Objective: To identify clinical predictors indicating the presence of pharyngeal dysphagia in patients at risk. Methods: We examined pharyngeal dysphagia in a large cohort of patients with Parkinson’s disease (n = 200) divided in three clinical subtypes (tremor-dominant (TD), mainly bradykinetic (BK) and early postural instability and gait difficulty PIGD)) by using flexible endoscopic evaluation of swallowing. ANOVA-multivariance analysis and following t-tests as well as binary logistic regression analysis were performed to detect group differences and to identify clinical predictors for dysphagia. Results: Statistically significant differences were found in the dysphagic group: age, male gender, disease duration, stage of the disease, Levodopa equivalent dose and higher scores on the Unified Parkinson’s disease rating scale III and II, item 7. The PIGD subtype was affected more frequently than the TD and BK subtype. In a logistic regression model higher age (>63.5 years p < 0.05) and Levodopa equivalent dose (>475 mg, p < 0.01) were identified to be independent predictors for the presence of pharyngeal dysphagia. Conclusion: Particularly patients with an age > 63.5 years and a daily Levodopa equivalent dose >475 mg show an increased risk for pharyngeal dysphagia. These findings may partly be influenced by presbyphagia but are likely to represent disease progression. The PIGD subtype seems to be a risk factor due to more pronounced dyscoordination of oropharyngeal muscle movements.

scholarly journals Prevalence and type of cervical deformities among adults with Parkinson's disease: a cross-sectional study

2016 ◽  
Vol 24 (4) ◽  
pp. 527-534 ◽  
Author(s):  
Bong Ju Moon ◽  
Justin S. Smith ◽  
Christopher P. Ames ◽  
Christopher I. Shaffrey ◽  
Virginie Lafage ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Cervical Spine ◽  
Logistic Regression Analysis ◽  
Control Group ◽  
Spine Deformities ◽  
Sagittal Malalignment ◽  
Age And Sex

OBJECT To identify the characteristics of cervical deformities in Parkinson's disease (PD) and the role of severity of PD in the development of cervical spine deformities, the authors investigated the prevalence of the cervical deformities, cervical kyphosis (CK), and cervical positive sagittal malalignment (CPSM) in patients with PD. They also analyzed the association of severity of cervical deformities with the stage of PD in the context of global sagittal spinopelvic alignment. METHODS This study was a prospective assessment of consecutively treated patients (n = 89) with PD. A control group of the age- and sex-matched patients was selected from patients with degenerative cervical spine disease but without PD. Clinical and demographic parameters including age, sex, duration of PD, and Hoehn and Yahr (H&Y) stage were collected. Full-length standing radiographs were used to assess spinopelvic parameters. CK was defined as a C2–7 Cobb angle < 0°. CPSM was defined as C2–7 sagittal vertical axis (SVA) > 4 cm. RESULTS A significantly higher prevalence of CPSM (28% vs 1.1%, p < 0.001), but not CK (12% vs 10.1%, p = 0.635), was found in PD patients compared with control patients. Among patients with PD, those with CK were younger (62.1 vs 69.0 years, p = 0.013) and had longer duration of PD (56.4 vs 36.2 months, p = 0.034), but the severity of PD was not significantly different. Logistic regression analysis revealed that the presence of CK was associated with younger age, higher mismatch between pelvic incidence and lumbar lordosis, and lower C7–S1 SVA. The patients with CPSM had significantly greater thoracic kyphosis (TK) (p < 0.001) and a trend toward more advanced H&Y stage (p = 0.05). Logistic regression analysis revealed that CPSM was associated with male sex, greater TK, and more advanced H&Y stage. CONCLUSIONS Patients with PD have a significantly higher prevalence of CPSM compared with age- and sex-matched control patients with cervical degenerative disease but without PD. Among patients with PD, CK is not associated with the severity of PD but is associated with overall global sagittal malalignment. In contrast, the presence of CPSM is associated more with the severity of PD than it is with the presence of global sagittal malalignment. Collectively, these data suggest that the neuromuscular pathogenesis of PD may affect the development of CPSM more than of CK.

An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment

Neurology ◽  
2001 ◽  
Vol 56 (Supplement 5) ◽  
pp. S1-S88 ◽  
Author(s):  
C. W. Olanow ◽  
R. L. Watts ◽  
W. C. Koller
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Decision Tree

scholarly journals Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Zubo Wu ◽  
Suyuan Wu ◽  
Tao Liang ◽  
Lin Wang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Risk Factor ◽  
Phospholipase A2 ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Multivariable Logistic Regression Analysis ◽  
Disease Course ◽  
Clinical Value

ObjectiveTo explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson’s disease (PD).MethodsA case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. According to the disease course and severity, PD patients were subdivided to analyze the clinical value of Lp-PLA2. Relationship between Lp-PLA2 and PD risk was analyzed by logistic regression. Diagnostic value of Lp-PLA2 in PD patients was investigated using receiver’s operator characteristic curves.ResultsLp-PLA2 level was significantly higher in the PD patients compared with the controls, and was significantly and positively correlated with the Hoehn-Yahr (H&amp;Y) stage. The serum Lp-PLA2 level and H&amp;Y stage of PD patients with a longer disease course were significantly higher than those with a shorter disease course. PD patients with milder conditions had significantly lower serum Lp-PLA2 levels than patients with severe conditions. Multivariable logistic regression analysis indicated higher Lp-PLA2 level was an independent risk factor of PD patients. Moreover, the area under the curve for Lp-PLA2 was 0.703, which was between those of homocysteine and serum amylase A.ConclusionTo our knowledge, this is the first study to show that increased level of Lp-PLA2 is associated with the risk of PD. Lp-PLA2 may be used for early detection of PD, and provides an effective intervention target for clinical treatment of PD.

A decision tree for differentiating multiple system atrophy from Parkinson’s disease using 3-T MR imaging

2013 ◽  
Vol 23 (6) ◽  
pp. 1459-1466 ◽  
Author(s):  
Shalini Rajandran Nair ◽  
Li Kuo Tan ◽  
Norlisah Mohd Ramli ◽  
Shen Yang Lim ◽  
Kartini Rahmat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mr Imaging ◽  
Decision Tree ◽  
Multiple System Atrophy
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