On the measurements of magnetic nanoparticle concentration in a biological medium using a superconducting quantum magnetometer

2020 ◽  
Vol 46 (11) ◽  
pp. 1094-1097
Author(s):  
S. I. Bondarenko ◽  
O. G. Avrunin ◽  
I. S. Bondarenko ◽  
A. V. Krevsun ◽  
V. P. Koverya ◽  
...  
Keyword(s):  
Magnetic Nanoparticle ◽  
Biological Medium ◽  
Nanoparticle Concentration ◽  
Quantum Magnetometer

scholarly journals Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

2015 ◽  
Vol 08 (02) ◽  
pp. 1550008 ◽  
Author(s):  
Yangyang Liu ◽  
Zhiyu Qian ◽  
Jianhua Yin ◽  
Xiao Wang
Keyword(s):  
Magnetic Field ◽  
Tumor Cells ◽  
Magnetic Nanoparticle ◽  
Tumor Therapy ◽  
Low Frequency ◽  
Alternating Magnetic Field ◽  
Nanoparticle Concentration ◽  
Field Frequency ◽  
A New Technique ◽  
The Magnetic Field

Magnetic nanoparticle plays an important role in biomedical engineering, especially in tumor therapy. In this paper, a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-frequency alternating magnetic field (LFAMF) to kill tumor cells. The LFAMF system which was used to drive magnetic nanoparticles (MNPs) was setup with the magnetic field frequency and power range at ∼ 10–100 Hz and ∼ 10–200 mT, respectively. During the experiment, the LFAMF was adjusted at different frequencies and power levels. The experimental results show that the liver tumor cells (HepG2) mixed with MNPs (10 μg/mL) became partial fragments when exposed in the LFAMF with different frequencies (∼ 10–100 Hz) and power (∼ 10–200 mT), and the higher the frequency or the power, the more the tumor cells were killed at the same magnetic nanoparticle concentration. Conclusion: Tumor cells were effectively damaged by MNPs under LFAMF, which suggests that they had great potential to be applied in tumor therapy.

scholarly journals The influence of magnetic nanoparticle concentration with dextran polymers in agar gel on heating efficiency in magnetic hyperthermia

2020 ◽  
Vol 304 ◽  
pp. 112734 ◽  
Author(s):  
Andrzej Skumiel ◽  
Katarzyna Kaczmarek ◽  
Dorota Flak ◽  
Michal Rajnak ◽  
Iryna Antal ◽  
...  
Keyword(s):  
Magnetic Nanoparticle ◽  
Magnetic Hyperthermia ◽  
Nanoparticle Concentration ◽  
Agar Gel ◽  
Heating Efficiency

Dependence of biomolecule detection on magnetic nanoparticle concentration

2021 ◽  
Vol 517 ◽  
pp. 167408
Author(s):  
Jing Zhong ◽  
Klaas-Julian Janssen ◽  
Sebastian Draack ◽  
Thilo Viereck ◽  
Meinhard Schilling ◽  
...  
Keyword(s):  
Magnetic Nanoparticle ◽  
Nanoparticle Concentration ◽  
Biomolecule Detection

Quantification of MicroCT Image Intensity and Nanoparticle Concentration in Agarose Gel

2012 ◽  
Author(s):  
A. LeBrun ◽  
N. Conn ◽  
A. Attaluri ◽  
N. Manuchehrabadi ◽  
Z. Huang ◽  
...  
Keyword(s):  
Concentration Distribution ◽  
Magnetic Nanoparticle ◽  
Experimental Studies ◽  
Index Number ◽  
Nanoparticle Concentration ◽  
Nanoparticle Distribution ◽  
Tissue Equivalent ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Scanned Images ◽  
Microct Imaging

In recent years, magnetic nanoparticle hyperthermia has attracted a lot of attentions in cancer treatment due to its ability to confine heat within the tumor with minimal collateral thermal damage to the surrounding healthy tissue.1–4 The success of the treatment using magnetic nanoparticles depends on careful planning of the heating duration and achieved temperature elevations. It has been demonstrated by previous research that the generated volumetric heat generation rate or Specific Absorption Rate (SAR) should be proportional to the nanoparticle concentration distribution in the tumors. The difficulty encountered by bioengineers is that the nanoparticle concentration distribution is often unknown, since the tissue is opaque. Recently, high-resolution microCT imaging technique has been used to visualize magnetic nanoparticle distribution in tumors. MicroCT has been shown to generate detailed 3-D density variations induced by nanoparticle depositions in both tissue-equivalent gels and tumor tissues.5–6 However, experimental studies are still needed to quantify the relationship between the microCT pixel index number shown in the scanned images and the actual nanoparticle concentrations.

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