Time‐dependent sheath response to abrupt electrode voltage changes

1990 ◽  
Vol 2 (3) ◽  
pp. 655-666 ◽  
Author(s):  
A. C. Calder ◽  
J. G. Laframboise
Keyword(s):  
Time Dependent ◽  
Electrode Voltage

scholarly journals Two types of Ca2+ currents with different sensitivities to organic Ca2+ channel antagonists in guinea pig pancreatic alpha 2 cells.

1988 ◽  
Vol 91 (2) ◽  
pp. 243-254 ◽  
Author(s):  
P Rorsman
Keyword(s):  
Steady State ◽  
Guinea Pig ◽  
Voltage Clamp ◽  
Maximum Amplitude ◽  
Time Dependent ◽  
Voltage Clamp Technique ◽  
Electrode Voltage ◽  
Steady State Inactivation ◽  
Ca2 Channels ◽  
Better Than

The possibility that guinea pig pancreatic alpha 2 cells are equipped with more than one type of Ca2+ channel was explored using the patch-electrode voltage-clamp technique. At a holding potential of -100 mV, a slowly developing (tau m approximately 5 ms at -40 mV assuming m2 kinetics) Ca2+ current appeared. This conductance first became detectable at potentials of about -60 mV and reached a maximum amplitude of 50-100 pA between -30 and -20 mV. During long depolarizations, it inactivated completely (tau h approximately 100 ms at -40 mV). Half-maximal steady state inactivation was observed at about -60 mV. A second, more rapidly developing (tau m approximately 2 ms at 0 mV) Ca2+ current was observed during pulses to -40 mV and above. It had a peak amplitude of 150-200 pA between 0 and 10 mV, was less dependent on the holding potential, and inactivated very little, even during long pulses. Both conductances were blocked by Co2+ but were unaffected by tetrodotoxin. The rapidly developing current differed from the slowly developing one in being sensitive to the antagonists D-600 and nifedipine, conducting Ba2+ better than Ca2+, increasing upon exposure to forskolin, and showing time-dependent decay (rundown). These findings indicate that the alpha 2 cells are equipped with two kinds of Ca2+ channels.

TIME-DEPENDENT PHENOMENA CAUSED BY THE EC DECAY IN Co2+ [Fe(CN)6]3-

1980 ◽  
Vol 41 (C1) ◽  
pp. C1-239-C1-240 ◽  
Author(s):  
Takayuki Kobayashi ◽  
Tetsuo Kitahara
Keyword(s):  
Time Dependent

Time-dependent changes in inflammatory markers in a rat model of colitis by leisure sport activity

2013 ◽  
Vol 51 (05) ◽  
Author(s):  
Z Szalai ◽  
K Kupai ◽  
A Magyariné Berkó ◽  
A Pósa ◽  
R Szabó ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Markers ◽  
Sport Activity ◽  
Time Dependent
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