Use of generalized two-dimensional correlation spectra to understand the reaction between poly(vinyl alcohol) and palladium (II) chloride

1998 ◽  
Author(s):  
Richard Wilson
Keyword(s):  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Two Dimensional

scholarly journals Preliminary Characterization of Genipin-Cross-Linked Silk Sericin/Poly(vinyl alcohol) Films as Two-Dimensional Wound Dressings for the Healing of Superficial Wounds

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Tippawan Siritientong ◽  
Juthamas Ratanavaraporn ◽  
Teerapol Srichana ◽  
Pornanong Aramwit
Keyword(s):  
Vinyl Alcohol ◽  
Light Transmission ◽  
Transmission Rate ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Cross Linking ◽  
Two Dimensional ◽  
Silk Sericin ◽  
Superficial Skin

The genipin-cross-linked silk sericin/poly(vinyl alcohol) (PVA) films were developed aiming to be applied as two-dimensional wound dressings for the treatment of superficial wounds. The effects of genipin cross-linking concentration on the physical and biological properties of the films were investigated. The genipin-cross-linked silk sericin/PVA films showed the increased surface density, tensile strength, and percentage of elongation, but decreased percentage of light transmission, water vapor transmission rate, and water swelling, compared to the non-cross-linked films. This explained that the cross-linking bonds between genipin and silk sericin would reduce the mobility of molecular chains within the films, resulting in the more rigid molecular structure. Silk sericin was released from the genipin-cross-linked films in a sustained manner. In addition, either L929 mouse fibroblast or HaCat keratinocyte cells showed high percentage of viability when cultured on the silk sericin/PVA films cross-linked with 0.075 and 0.1% w/v genipin. Thein vivosafety test performed according to ISO 10993-6 confirmed that the genipin-cross-linked silk sericin/PVA films were safe for the medical usages. The efficacy of the films for the treatment of superficial skin wounds will be further investigatedin vivoand clinically. The genipin-cross-linked silk sericin/PVA films would be promising choices of two-dimensional wound dressings for the treatment of superficial wounds.

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