scholarly journals Potential role of glyceollin as anti-metastatic agent through transforming growth factor-β receptors inhibition signaling pathways: A computational study

2019 ◽  
Author(s):  
Feri Eko Hermanto ◽  
Muhaimin Rifa’i ◽  
Widodo
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Potential Role ◽  
Transforming Growth Factor ◽  
Computational Study ◽  
Transforming Growth Factor Β

scholarly journals Evidence for a Role of MSK1 in Transforming Growth Factor-β-mediated Responses through p38α and Smad Signaling Pathways

2004 ◽  
Vol 279 (29) ◽  
pp. 30474-30479 ◽  
Author(s):  
Lucile Abécassis ◽  
Edith Rogier ◽  
Aimé Vazquez ◽  
Azzedine Atfi ◽  
Marie-Françoise Bourgeade
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Smad Signaling

The role of transforming growth factor β in glaucoma and the therapeutic implications

2013 ◽  
Vol 97 (6) ◽  
pp. 680-686 ◽  
Author(s):  
Mark A Prendes ◽  
Alon Harris ◽  
Barbara M Wirostko ◽  
Austin L Gerber ◽  
Brent Siesky
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Therapeutic Implications

scholarly journals The Exploration of Poor Ovarian Response–Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient

2021 ◽  
Vol 12 ◽  
Author(s):  
Long Bai ◽  
Huihui Pan ◽  
Yinjun Zhao ◽  
Qingqing Chen ◽  
Yu Xiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Growth Factor ◽  
Potential Role ◽  
Transforming Growth Factor ◽  
Ovarian Response ◽  
Poor Ovarian Response ◽  
Aberrant Expression ◽  
Differentiation Factor ◽  
Ivf Et

Controlled ovarian hyperstimulation (COH) is the most common therapeutic protocol to obtain a considerable number of oocytes in IVF-ET cycles. To date, the risk factors affecting COH outcomes remain elusive. Growth differentiation factor 8 (GDF-8), a member of transforming growth factor β (TGF-β) superfamily, has been long discerned as a crucial growth factor in folliculogenesis, and the aberrant expression of GDF-8 is closely correlated with the reproductive diseases. However, less is known about the level of GDF-8 in IVF-ET patients with different ovarian response. In the present study, the potential risk factors correlated with ovarian response were explored using logistic regression analysis methods. Meanwhile, the expression changes of GDF-8 and its responsible cellular receptors in various ovarian response patients were determined. Our results showed that several factors were intensely related to poor ovarian response (POR), including aging, obesity, endometriosis, surgery history, and IVF treatment, while irregular menstrual cycles and PCOS contribute to hyperovarian response (HOR). Furthermore, POR patients exhibited a decrease in numbers of MII oocytes and available embryos, thereby manifesting a lower clinical pregnancy rate. The levels of GDF-8, ALK5, and ACVR2B in POR patients were higher compared with those in control groups, whereas the expression level of ACVR2A decreased in poor ovarian response patients. In addition, clinical correlation analysis results showed that the concentration of GDF-8 was negatively correlated with LH and estradiol concentration and antral follicle count. Collectively, our observations provide a novel insight of ovarian response–associated risk factors, highlighting the potential role of GDF-8 levels in ovarian response during COH process.

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