Synthesis of (S)-naproxen based amide bond forming chiral reagent and application for liquid chromatographic resolution of (RS)-salbutamol

2019 ◽  
Author(s):  
Poonam Malik ◽  
Ravi Bhushan
Keyword(s):  
Amide Bond ◽  
Bond Forming ◽  
Chiral Reagent ◽  
Chromatographic Resolution ◽  
Liquid Chromatographic

scholarly journals Site-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yunyun Ning ◽  
Shuaishuai Wang ◽  
Muzi Li ◽  
Jie Han ◽  
Chengjian Zhu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Functional Group ◽  
Amide Bond ◽  
Coupling Reagents ◽  
Complex Molecules ◽  
Bond Forming ◽  
Synergistic Catalysis ◽  
Wide Range ◽  
Amidation Reaction ◽  
Forming Methods

AbstractDevelopment of catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. In this paper, we disclose an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI2, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participate smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield). This Umpolung amidation strategy opens a method to address challenging regioselectivity issues between nucleophilic functional groups, and complements the functional group compatibility of the classical amidation protocols. The synthetic robustness of the reaction is demonstrated by late-stage modification of complex molecules and gram-scale applications.

scholarly journals Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions

2020 ◽  
Vol 24 (7) ◽  
pp. 1341-1349 ◽  
Author(s):  
Marion Erny ◽  
Marika Lundqvist ◽  
Jon H. Rasmussen ◽  
Olivier Ludemann-Hombourger ◽  
Frédéric Bihel ◽  
...  
Keyword(s):  
Amide Bond ◽  
Bond Forming ◽  
Bond Forming Reactions

NEW CHIRAL STATIONARY PHASES FOR THE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS

1986 ◽  
Vol 15 (4) ◽  
pp. 515-518 ◽  
Author(s):  
Kazuhiko Saigo ◽  
Yun Chen ◽  
Naomi Kubota ◽  
Kouzou Tachibana ◽  
Noriyuki Yonezawa ◽  
...  
Keyword(s):  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
High Performance Liquid Chromatographic ◽  
Resolution Of Enantiomers ◽  
Chromatographic Resolution ◽  
Liquid Chromatographic
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