The effect of Acalypha indica Linn. extract on insulin resistance in Sprague-Dawley rats after induction of high cholesterol-high fructose diet

2019 ◽  
Author(s):  
Desak Gede Budi Krisnamurti ◽  
Erza Pinayungan ◽  
Rani Wardani Hakim ◽  
Erni H. Purwaningsih
Keyword(s):  
Insulin Resistance ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
High Fructose Diet ◽  
Sprague Dawley Rats ◽  
High Fructose ◽  
Acalypha Indica

scholarly journals Uric acid and glucose level in high fructose high cholesterol induced Sprague-Dawley rats after therapy with Acalypha indica Linn. ethanol extract

2019 ◽  
Author(s):  
Desak Gede Budi Krisnamurti ◽  
Fira Alyssa Gabriella Sinuraya ◽  
Tamara Ey Firsty ◽  
Rani Wardani Hakim ◽  
Erni H. Purwaningsih
Keyword(s):  
Uric Acid ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Sprague Dawley Rats ◽  
High Fructose ◽  
Acalypha Indica

Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats

2009 ◽  
Vol 327 (1-2) ◽  
pp. 247-256 ◽  
Author(s):  
Mohammad M. Abdullah ◽  
Natalie N. Riediger ◽  
Qilin Chen ◽  
Zhaohui Zhao ◽  
Nazila Azordegan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Sprague Dawley ◽  
High Fructose Diet ◽  
Sprague Dawley Rats ◽  
High Fructose

scholarly journals Effects of Dietary Brown Rice on Carcass Composition and Nitric Oxide (NOx) Metabolite Levels in High-Fat High-Fructose Diet-induced Sprague Dawley Rats as Obesity Model

2020 ◽  
Vol 1665 ◽  
pp. 012007
Author(s):  
Dian Handayani ◽  
Ahmad Ramadhan ◽  
Risma Debby Anindyanti ◽  
Alma Maghfirotun Innayah ◽  
Etik Sulistyowati ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brown Rice ◽  
Carcass Composition ◽  
Sprague Dawley ◽  
High Fat ◽  
High Fructose Diet ◽  
Sprague Dawley Rats ◽  
High Fructose

Effect of crude Moringa oleifera Lam. seed extract on the blood markers of metabolic syndrome in high-fructose diet-fed growing Sprague-Dawley rats

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Masiline Mapfumo ◽  
Busisani W. Lembede ◽  
Ashwell R. Ndhlala ◽  
Eliton Chivandi
Keyword(s):  
Body Mass ◽  
Moringa Oleifera ◽  
Seed Extract ◽  
Plasma Triglyceride ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
High Fructose Diet ◽  
Sprague Dawley Rats ◽  
High Fructose

AbstractBackgroundMoringa oleifera seed has anti-diabetic and anti-obesogenic properties. This study interrogated the effect of crude hydroethanolic M. oleifera seed extract on the blood markers of metabolic syndrome (MetS) in high-fructose diet fed growing Sprague-Dawley rats.MethodsSixty 21-day old female and male Sprague-Dawley rat pups were randomly allocated to and administered one of the following treatment regimens daily for twelve weeks: group I – plain drinking water (PW)+plain gelatine cube (PC), group II – 20% (w/v) fructose solution (FS)+PC, group III – FS+100 mg/kg body mass fenofibrate in gelatine cube (FN), group IV – FS+low dose (50 mg/kg body mass) of M. oleifera in gelatine cube (LMol) and group V – FS+high dose (500 mg/kg body mass) of M. oleifera in gelatine cube (HMol). The rats in each treatment regimen had ad libitum access to a standard rat chow. After the 12-week trial, the rats were subjected to an oral glucose tolerance test and then euthanised 48 h later. Blood was collected. Plasma triglyceride, cholesterol and insulin concentration were determined. HOMA-IR was then computed.ResultsThe high-fructose diet increased (p<0.05) plasma insulin concentration and HOMA-IR in female rats only. It increased plasma triglyceride concentration in both female and male rats and plasma cholesterol concentration in male rats only. The crude hydroethanolic M. oleifera seed extract prevented the high-fructose diet-induced metabolic derangements in male and female rats.ConclusionCrude hydroethanolic M. oleifera seed extract can potentially be used as a prophylactic intervention for diet-induced MetS in children.

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