scholarly journals Measuring volume kinetics of human monocytes in response to cryoprotectants using microfluidic technologies

2019 ◽  
Vol 114 (22) ◽  
pp. 223702
Author(s):  
Rekha Raju ◽  
Hannes Höhn ◽  
Christian Karnutsch ◽  
Khashayar Khoshmanesh ◽  
Gary Bryant
Keyword(s):  
Human Monocytes ◽  
Measuring Volume ◽  
Volume Kinetics ◽  
Kinetics Of

scholarly journals Population-based volume kinetics of Ringer’s lactate solution in patients undergoing open gastrectomy

2018 ◽  
Vol 40 (5) ◽  
pp. 710-716 ◽  
Author(s):  
Joo-Hyun Lee ◽  
Yeong-Jin Choo ◽  
Yong-Hun Lee ◽  
Jin-Ho Rhim ◽  
Soo-Han Lee ◽  
...  
Keyword(s):  
Population Based ◽  
Open Gastrectomy ◽  
Ringer’S Lactate ◽  
Volume Kinetics ◽  
Kinetics Of ◽  
Lactate Solution

scholarly journals Volume kinetics of Ringer solution after surgery for hip fracture

1999 ◽  
Vol 46 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Christer Svensén ◽  
Sari Ponzer ◽  
Robert G. Hahn
Keyword(s):  
Hip Fracture ◽  
Ringer Solution ◽  
Volume Kinetics ◽  
Kinetics Of

scholarly journals Iron Release From Human Monocytes After Erythrophagocytosis In Vitro: An Investigation in Normal Subjects and Hereditary Hemochromatosis Patients

Blood ◽  
1998 ◽  
Vol 92 (7) ◽  
pp. 2511-2519 ◽  
Author(s):  
Eunice Moura ◽  
Minke A. Noordermeer ◽  
Nanda Verhoeven ◽  
Andreas F.M. Verheul ◽  
Joannes J.M. Marx
Keyword(s):  
Hereditary Hemochromatosis ◽  
Transferrin Saturation ◽  
Normal Subjects ◽  
Human Monocytes ◽  
Iron Release ◽  
Rapid Phase ◽  
Low Molecular Weight Iron ◽  
Kinetics Of ◽  
Later Phase

Abstract This study investigated the release of erythrocyte-derived iron from purified human monocytes obtained from healthy volunteers and hereditary hemochromatosis (HH) patients. After erythrophagocytosis of59Fe-labeled erythrocytes, a complete transfer of iron from hemoglobin (Hb) to ferritin was observed within 24 hours in both control and HH monocytes. The iron was released from the monocytes in the form of ferritin, Hb, and as nonprotein bound low molecular weight iron (LMW-Fe). During the initial rapid phase (<1.5 hours), iron release mostly consisted of Hb and LMW-Fe, while in the later phase (>1.5 hours), it was composed of ferritin and LMW-Fe. The kinetics of iron release were identical for HH monocytes. A high percentage of the total amount of iron was released as Hb both by viable normal and HH monocytes, suggesting that iron release as Hb is a physiologic process, which may occur whenever the erythrocyte-processing capacity of macrophages is exceeded. Most remarkably, HH monocytes released twice as much iron in a LMW form as control cells. Iron released in the form of LMW-Fe readily binds to plasma transferrin and may contribute to the high transferrin saturation and the occurrence of circulating nontransferrin-bound iron observed in HH patients.

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