Optimal control of innate immune response on lung-macrophages in pneumonia

2019 ◽  
Author(s):  
Usman Pagalay ◽  
Dewi Zumrotul Nafisa ◽  
Heni Widayani
Keyword(s):  
Optimal Control ◽  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Lung Macrophages

Optimal control of innate immune response

2002 ◽  
Vol 23 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Robert F. Stengel ◽  
Raffaele Ghigliazza ◽  
Nilesh Kulkarni ◽  
Olivier Laplace
Keyword(s):  
Optimal Control ◽  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune

Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages

2007 ◽  
Vol 214 (1) ◽  
pp. 27-37 ◽  
Author(s):  
Mark A. Birrell ◽  
Sissie Wong ◽  
Matthew C. Catley ◽  
Maria G. Belvisi
Keyword(s):  
Immune Response ◽  
Signaling Pathways ◽  
Innate Immune Response ◽  
Tobacco Smoke ◽  
Innate Immune ◽  
Lung Macrophages

scholarly journals Optimal Control Strategy for Abnormal Innate Immune Response

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Jinying Tan ◽  
Xiufen Zou
Keyword(s):  
Optimal Control ◽  
Immune Response ◽  
Viral Infection ◽  
Innate Immune Response ◽  
Control Strategies ◽  
Antiviral Treatment ◽  
Equation System ◽  
Innate Immune ◽  
Optimal Control Strategy ◽  
Existence Of A Solution

Innate immune response plays an important role in control and clearance of pathogens following viral infection. However, in the majority of virus-infected individuals, the response is insufficient because viruses are known to use different evasion strategies to escape immune response. In this study, we use optimal control theory to investigate how to control the innate immune response. We present an optimal control model based on an ordinary-differential-equation system from a previous study, which investigated the dynamics and regulation of virus-triggered innate immune signaling pathways, and we prove the existence of a solution to the optimal control problem involving antiviral treatment or/and interferon therapy. We conduct numerical experiments to investigate the treatment effects of different control strategies through varying the cost function and control efficiency. The results show that a separate treatment, that is, only inhibiting viral replication (u1(t)) or enhancing interferon activity (u2(t)), has more advantages for controlling viral infection than a mixed treatment, that is, controlling both (u1(t)) and (u2(t)) simultaneously, including the smallest cost and operability. These findings would provide new insight for developing effective strategies for treatment of viral infectious diseases.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

IL-17C is a mediator of respiratory epithelial innate immune response

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Pfeifer ◽  
M Voss ◽  
B Wonnenberg ◽  
M Bischoff ◽  
F Langer ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Respiratory Epithelial
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