Development of a compact laser-diode based frequency domain photoacoustic sensing system: Application of human breast cancer diagnosis

2019 ◽  
Vol 90 (11) ◽  
pp. 114101
Author(s):  
Abhijeet Gorey ◽  
Srivathsan Vasudevan ◽  
M. S. Ansari ◽  
Priyanka Bhagat ◽  
Satish Phatak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Laser Diode ◽  
Cancer Diagnosis ◽  
System Application ◽  
Human Breast Cancer ◽  
Breast Cancer Diagnosis ◽  
Human Breast ◽  
Sensing System

Capture of Very Rare Circulating Tumor Cells for Human Breast Cancer Diagnosis

2007 ◽  
Author(s):  
Taehyun Park ◽  
Timothy Jensen ◽  
Daniel Park ◽  
Jason Guy ◽  
Proyag Datta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Human Breast Cancer ◽  
Microfluidic Channel ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Cell Lines ◽  
Target Cells ◽  
Human Breast

A method of collecting and delivering single or precise numbers of cells to assess the feasibility of capturing very rare circulating tumor cells for human breast cancer diagnosis and monitoring was developed. A PMMA device was assembled with minimal assembly variation using passive alignment. Thermoplastic fusion bonding was optimized to yield minimal deformation of the microfluidic channel. UV modification and an anti-epithelial cell adhesion molecule (anti-EpCAM) functionalization process were used to generate capture surfaces and maximized by control experiment. Single or precise numbers of target cells were collected using a cell collecting capillary tube and a hemacytometer and delivered into the microchannel without any loss. Cells from one of the human breast cancer cell lines, the MCF-7 cell line (ATCC, Manassas, VA) which strongly overexpresses EpCAM, were successfully captured on the anti-EpCAM coated microchannel surfaces. Successful capture of early stage breast cancer cells in whole blood may be feasible with further optimization of the microchannel geometry and flow velocity through the microfluidic device.

Raman spectroscopy and imaging: applications in human breast cancer diagnosis

The Analyst ◽  
2012 ◽  
Vol 137 (16) ◽  
pp. 3773 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Jacek Musial ◽  
Radzislaw Kordek ◽  
Elena Bailo ◽  
Thomas Dieing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Raman Spectroscopy ◽  
Cancer Diagnosis ◽  
Human Breast Cancer ◽  
Breast Cancer Diagnosis ◽  
Human Breast

Magnetic resonance guided optical spectroscopy imaging of human breast cancer using a combined frequency domain and continuous wave approach

2012 ◽  
Author(s):  
Michael A. Mastanduno ◽  
Scott C. Davis ◽  
Shudong Jiang ◽  
Roberta diFlorio-Alexander ◽  
Brian W. Pogue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance ◽  
Frequency Domain ◽  
Optical Spectroscopy ◽  
Human Breast Cancer ◽  
Continuous Wave ◽  
Human Breast ◽  
Wave Approach

Certain Study on Improvement of Bandwidth in 3GHz Microstrip Patch Antenna Designs and Implemented on Monostatic Radar Approach for Breast Cancer Diagnosis in Microwave Imaging System

2015 ◽  
Vol 25 (02) ◽  
pp. 1650006 ◽  
Author(s):  
K. Sakthisudhan ◽  
N. Saravana Kumar
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Imaging System ◽  
Breast Cancer Diagnosis ◽  
Patch Antennas ◽  
Human Breast ◽  
Test Bed ◽  
Microstrip Patch Antennas ◽  
Microstrip Patch ◽  
Tumor Tissues

A 3[Formula: see text]GHz class of an EF and [Formula: see text] shaped Microstrip Patch Antennas (MPAs) designed, simulated and fabricated has been presented in this paper. These simulated designs with appropriate parameters are implemented on the fabrication prototypes which have been validated with help of Agilent Microwave Analyzer (N99917A). These proposed MPAs and dielectric equivalent human breast model that have been validated using the different dielectric strengths of coupling mediums are presented. These MPAs and dielectric equivalent human breast model have been validated using the existing Debye test bed. The coverage and vector dimension of tumor tissues have been detected using the Monostatic radar approach in the EF and [Formula: see text] shaped MPAs-based existing Debye test bed setups. This paper conclude that Fractional Bandwidth (FBW) of EF shaped MPA is 26.79% greater than [Formula: see text] shaped MPA of 21.67%. Hence, the EF and [Formula: see text] shaped MPAs prototypes are suitable for breast cancer diagnosis systems. The prototypes’ depth, coverage and vector dimensions are presented in this paper.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

1968 ◽  
Vol 26 ◽  
pp. 224-225
Author(s):  
John L. Swedo ◽  
R. W. Talley ◽  
John H. L. Watson
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Estrogen Therapy ◽  
Specimen Preparation ◽  
Human Breast ◽  
Autophagic Vacuoles ◽  
Previous Communication ◽  
Linear Profiles ◽  
Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

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