Effects of l-glutamic acid, gamma-aminobutiric acid and kainic acid on the surface electrical charge and enzyme activity of rat brain synaptosomes

2019 ◽  
Author(s):  
V. Doltchinkova ◽  
M. Shkodrova ◽  
N. Mouleshkova ◽  
S. Stoylov
Keyword(s):  
Enzyme Activity ◽  
Glutamic Acid ◽  
Rat Brain ◽  
Kainic Acid ◽  
Electrical Charge ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Effect of Kainic Acid Lesions on Taurine Transport into Rat Brain Synaptosomes

1981 ◽  
pp. 73-80 ◽  
Author(s):  
Henry I. Yamamura ◽  
Robert C. Speth ◽  
Robert E. Hruska ◽  
Nereo Bresolin ◽  
Brad A. Meiners ◽  
...  
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Taurine Transport ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Na-K-ATPase activity decreases with aging in female rat brain synaptosomes

2001 ◽  
Vol 281 (4) ◽  
pp. F674-F678 ◽  
Author(s):  
Cosmo L. Fraser ◽  
Allen I. Arieff
Keyword(s):  
Enzyme Activity ◽  
Atpase Activity ◽  
Rat Brain ◽  
Potassium Transport ◽  
Female Rats ◽  
Female Rat ◽  
Adaptive Mechanism ◽  
Transport Function ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

To understand why elderly females are better able to tolerate hyponatremia, we measured brain Na-K-ATPase activity to determine whether this adaptive mechanism was affected by age. Using synaptosomes from 2-, 12-, and 19-mo-old female rats, we show in our results that Na-K-ATPase activity changes with age in female rats. Enzyme activity was significantly ( P = 0.0026) reduced (17%) from 0.416 ± 0.01 at 2 mo to 0.345 ± 0.01 at 12 mo and reduced ( P = 0.0001) (34%) to 0.274 ± 0.02 μmol · min−1 · mg protein−1 at 19 mo. To determine whether this decrease was due to reduced transport function of the Na-K-ATPase pump, we performed potassium transport using rubidium (86Rb+) as tracer. Ouabain-sensitive potassium uptake at 2 mo was 16.18 ± 1.31 nmol/mg protein, was significantly ( P = 0.0063) reduced (39%) to 9.79 ± 1.44 nmol/mg at 12 mo, and was significantly ( P = 0.0003) reduced (62%) to 6.12 ± 1.05 nmol/mg protein at 19 mo. On the contrary, Na-K-ATPase activity remained elevated in males during aging. These data suggest that the Na-K-ATPase pump in female rat brain synaptosomes is decreased with increased age, and that this decrease is probably due in part to decreased potassium transport by the Na-K-ATPase pump.

Effects of Kainic Acid in Rat Brain Synaptosomes: The Involvement of Calcium

1984 ◽  
Vol 43 (3) ◽  
pp. 747-754 ◽  
Author(s):  
Anna Pastuszko ◽  
David F. Wilson ◽  
M. Erecińska
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

scholarly journals Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes.

1994 ◽  
Vol 269 (14) ◽  
pp. 10498-10503 ◽  
Author(s):  
T. Nishiki ◽  
Y. Kamata ◽  
Y. Nemoto ◽  
A. Omori ◽  
T. Ito ◽  
...  
Keyword(s):  
Rat Brain ◽  
Clostridium Botulinum ◽  
Type B ◽  
Rat Brain Synaptosomes ◽  
Protein Receptor ◽  
Botulinum Type ◽  
Brain Synaptosomes

Is the Augmentation of K+-Evoked Intrasynaptosomal Ca2+Concentration Due to the Influx of Ca2+in Rat Brain Synaptosomes?

1989 ◽  
Vol 52 (6) ◽  
pp. 1837-1842 ◽  
Author(s):  
Mitsuko Okada ◽  
Kazunori Mine ◽  
Katsunori Iwasaki ◽  
Michihiro Fujiwara
Keyword(s):  
Rat Brain ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes
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