A computational study of the bioheat transfer in magnetic hyperthermia cancer therapy

2019 ◽  
Vol 125 (19) ◽  
pp. 194701 ◽  
Author(s):  
Iordana Astefanoaei ◽  
Alexandru Stancu
Keyword(s):  
Cancer Therapy ◽  
Computational Study ◽  
Magnetic Hyperthermia ◽  
Bioheat Transfer

scholarly journals Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 502
Author(s):  
Hanene Belkahla ◽  
Andrei Alexandru Constantinescu ◽  
Tijani Gharbi ◽  
Florent Barbault ◽  
Alexandre Chevillot-Biraud ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cancer Therapy ◽  
Computational Study ◽  
Carcinoma Cells ◽  
Maghemite Nanoparticles ◽  
Carboxylic Acid Groups ◽  
Lung Carcinoma Cells ◽  
Biological Studies ◽  
Apoptotic Effect ◽  
Carboxylic Groups

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case.

Photonic/magnetic hyperthermia-synergistic nanocatalytic cancer therapy enabled by zero-valence iron nanocatalysts

Biomaterials ◽  
2019 ◽  
Vol 219 ◽  
pp. 119374 ◽  
Author(s):  
Chen Dai ◽  
Chunmei Wang ◽  
Ruizhi Hu ◽  
Han Lin ◽  
Zhuang Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Magnetic Hyperthermia

99mTc-, 90Y-, and 177Lu-Labeled Iron Oxide Nanoflowers Designed for Potential Use in Dual Magnetic Hyperthermia/Radionuclide Cancer Therapy and Diagnosis

2019 ◽  
Vol 11 (44) ◽  
pp. 41109-41117 ◽  
Author(s):  
Miloš Ognjanović ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
Željko Prijović ◽  
Maria del Puerto Morales ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Magnetic Hyperthermia ◽  
Therapy And Diagnosis ◽  
Potential Use

Fucoidan-coated core–shell magnetic mesoporous silica nanoparticles for chemotherapy and magnetic hyperthermia-based thermal therapy applications

2017 ◽  
Vol 41 (24) ◽  
pp. 15334-15346 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Bharathiraja Subramanian ◽  
Manivasagan Panchanathan ◽  
Sudip Mondal ◽  
Hyehyun Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Thermal Therapy ◽  
Core Shell ◽  
Magnetic Mesoporous Silica

Fucoidan-coated FeNP@SiOH@Fuc NPs have been proposed for chemotherapy and thermal therapy applications in emerging cancer therapy.

scholarly journals Computational Study Regarding CoxFe3−xO4 Ferrite Nanoparticles with Tunable Magnetic Properties in Superparamagnetic Hyperthermia for Effective Alternative Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3294
Author(s):  
Costica Caizer
Keyword(s):  
Cancer Therapy ◽  
Computational Study ◽  
Tumor Therapy ◽  
Computational Simulation ◽  
Ferrite Nanoparticles ◽  
Specific Loss ◽  
Nanoparticle Diameter ◽  
Specific Loss Power ◽  
Wide Range ◽  
Range Of Values

The efficacy in superparamagnetic hyperthermia (SPMHT) and its effectiveness in destroying tumors without affecting healthy tissues depend very much on the nanoparticles used. Considering the results previously obtained in SPMHT using magnetite and cobalt ferrite nanoparticles, in this paper we extend our study on CoxFe3−xO4 nanoparticles for x = 0–1 in order to be used in SPMHT due to the multiple benefits in alternative cancer therapy. Due to the possibility of tuning the basic observables/parameters in SPMHT in a wide range of values by changing the concentration of Co2+ ions in the range 0–1, the issue explored by us is a very good strategy for increasing the efficiency and effectiveness of magnetic hyperthermia of tumors and reducing the toxicity levels. In this paper we studied by computational simulation the influence of Co2+ ion concentration in a very wide range of values (x = 0–1) on the specific loss power (Ps) in SPMHT and the nanoparticle diameter (DM) which leads to the maximum specific loss power (PsM). We also determined the maximum specific loss power for the allowable biological limit (PsM)l which doesn’t affect healthy tissues, and how it influences the change in the concentration of Co2+ ions. Based on the results obtained, we established the values for concentrations (x), nanoparticle diameter (DM), amplitude (H) and frequency (f) of the magnetic field for which SPMHT with CoxFe3−xO4 nanoparticles can be applied under optimal conditions within the allowable biological range. The obtained results allow the obtaining a maximum efficacy in alternative and non-invasive tumor therapy for the practical implementation of SPMHT with CoxFe3−xO4 nanoparticles.

scholarly journals Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles

2019 ◽  
Vol 5 (4) ◽  
pp. 67 ◽  
Author(s):  
Ihab M. Obaidat ◽  
Venkatesha Narayanaswamy ◽  
Sulaiman Alaabed ◽  
Sangaraju Sambasivam ◽  
Chandu V. V. Muralee Gopi
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Heat Generation ◽  
Colloidal Stability ◽  
Field Research ◽  
Magnetic Hyperthermia ◽  
Cellular Level ◽  
Effect Of Temperature ◽  
Factors Affecting

Hyperthermia is a noninvasive method that uses heat for cancer therapy where high temperatures have a damaging effect on tumor cells. However, large amounts of heat need to be delivered, which could have negative effects on healthy tissues. Thus, to minimize the negative side effects on healthy cells, a large amount of heat must be delivered only to the tumor cells. Magnetic hyperthermia (MH) uses magnetic nanoparticles particles (MNPs) that are exposed to alternating magnetic field (AMF) to generate heat in local regions (tissues or cells). This cancer therapy method has several advantages, such as (a) it is noninvasive, thus requiring surgery, and (b) it is local, and thus does not damage health cells. However, there are several issues that need to achieved: (a) the MNPs should be biocompatible, biodegradable, with good colloidal stability (b) the MNPs should be successfully delivered to the tumor cells, (c) the MNPs should be used with small amounts and thus MNPs with large heat generation capabilities are required, (d) the AMF used to heat the MNPs should meet safety conditions with limited frequency and amplitude ranges, (e) the changes of temperature should be traced at the cellular level with accurate and noninvasive techniques, (f) factors affecting heat transport from the MNPs to the cells must be understood, and (g) the effect of temperature on the biological mechanisms of cells should be clearly understood. Thus, in this multidisciplinary field, research is needed to investigate these issues. In this report, we shed some light on the principles of heat generation by MNPs in AMF, the limitations and challenges of MH, and the applications of MH using multifunctional hybrid MNPs.

scholarly journals Magnetic hyperthermia-induced drug release from ureasil-PEO-γ-Fe2O3 nanocomposites

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63291-63295 ◽  
Author(s):  
B. L. Caetano ◽  
C. Guibert ◽  
R. Fini ◽  
J. Fresnais ◽  
S. H. Pulcinelli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Hybrid Material ◽  
Magnetic Hyperthermia ◽  
Stimuli Responsive

A multifunctional hybrid material suitable for cancer therapy, combining stimuli-responsive properties for drug delivery and magnetic hyperthermia.

Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment

ACS Nano ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 2436-2446 ◽  
Author(s):  
Ana Espinosa ◽  
Riccardo Di Corato ◽  
Jelena Kolosnjaj-Tabi ◽  
Patrice Flaud ◽  
Teresa Pellegrino ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Heating Efficiency

scholarly journals Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology

RSC Advances ◽  
2021 ◽  
Vol 11 (28) ◽  
pp. 16942-16954
Author(s):  
Ruby Gupta ◽  
Ruchi Tomar ◽  
Suvankar Chakraverty ◽  
Deepika Sharma
Keyword(s):  
Magnetic Field ◽  
Response Surface Methodology ◽  
Cancer Therapy ◽  
Response Surface ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Alternating Magnetic Field ◽  
Magnetic Nanomaterials ◽  
Manganese Doping

Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is a promising antitumoral nanotherapy, owning to its power to generate heat under the application of an alternating magnetic field.

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