Opportunities and prospects for the use of porous silicon to create a polymer-free drug coating on intravascular stents

2018 ◽  
Author(s):  
Oleg A. Kashin ◽  
Konstantin V. Krukovskii ◽  
Alexander I. Lotkov
Keyword(s):  
Porous Silicon ◽  
Free Drug ◽  
Intravascular Stents ◽  
Drug Coating

scholarly journals pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

2021 ◽  
Vol 12 ◽  
pp. 1127-1139
Author(s):  
Karishma Berta Cotta ◽  
Sarika Mehra ◽  
Rajdip Bandyopadhyaya
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Drug Release ◽  
Iron Oxide Nanoparticles ◽  
Drug Loading ◽  
Drug Carriers ◽  
Free Drug ◽  
Release Profile ◽  
Oxide Nanoparticles ◽  
Drug Coating

Nanoparticle deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated with stabilizing agents. We hypothesize that, zwitterionic drugs like norfloxacin (NOR, a fluoroquinolone) can manifest dual functionality – nanoparticle stabilization and antibiotic activity, eliminating the need of a separate stabilizing agent. Since these drugs have different charges, depending on the surrounding pH, drug loading enhancement could be pH dependent. Hence, upon synthesizing IONPs, they were coated with NOR, either at pH 5 (predominantly as cationic, NOR+) or at pH 10 (predominantly as anionic, NOR−). We observed that, drug loading at pH 5 exceeded that at pH 10 by 4.7–5.7 times. Furthermore, only the former (pH 5 system) exhibited a desirable slower drug release profile, compared to the free drug. NOR-coated IONPs also enable a 22 times higher drug accumulation in macrophages, compared to identical extracellular concentrations of the free drug. Thus, lowering the drug coating pH to 5 imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release.

Calculation of exchange energy in quantum dots : application to porous silicon

1993 ◽  
Vol 03 (C5) ◽  
pp. 355-358 ◽  
Author(s):  
G. FISHMAN ◽  
R. ROMESTAIN ◽  
J. C. VIAL
Keyword(s):  
Quantum Dots ◽  
Porous Silicon ◽  
Exchange Energy

ANTI-REFLECTIVE PROPERTIES OF GRADIENT-POROUS SILICON

2017 ◽  
pp. 16-25
Author(s):  
E. A. Gosteva ◽  
V. V. Starkov ◽  
Yu. N. Parhomenko ◽  
M. O. Kah ◽  
I. A. Iwe
Keyword(s):  
Porous Silicon

Investigation of Porous Silicon/Carbon Composite as Anodes for Lithium Ion Batteries

2015 ◽  
Vol 30 (4) ◽  
pp. 351 ◽  
Author(s):  
HUANG Yan-Hua ◽  
HAN Xiang ◽  
CHEN Hui-Xin ◽  
CHEN Song-Yan ◽  
YANG Yong
Keyword(s):  
Porous Silicon ◽  
Lithium Ion Batteries ◽  
Lithium Ion ◽  
Carbon Composite ◽  
Silicon Carbon

Scattering Rings in Birefringent Porous Silicon

2003 ◽  
Vol 762 ◽  
Author(s):  
Claudio J. Oton ◽  
Zeno Gaburro ◽  
Mher Ghulinyan ◽  
Nicola Daldosso ◽  
Lucio Pancheri ◽  
...  
Keyword(s):  
Dielectric Constant ◽  
Light Scattering ◽  
Porous Silicon ◽  
Direct Measurement ◽  
Optical Anisotropy ◽  
Oblique Incidence ◽  
Laser Light ◽  
Anisotropic Scattering ◽  
Scattering Measurements

AbstractWe report the observation of strongly anisotropic scattering of laser light at oblique incidence on (100)-oriented porous silicon layers. We performed angle-resolved light scattering measurements and three concentric rings were observed. Modeling porous silicon by means of nanometric columnar air pores and an effective anisotropic uniaxial dielectric constant explains the observed phenomenon, and besides, the observation of the angle aperture of these rings allows a direct measurement of relative birefringence. We finally study the changes of optical anisotropy after different modifications of the structure.

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