scholarly journals Synthesis of mesoporous silica materials via dual templating method from starch of waste rice and their application for drug delivery system

2018 ◽  
Author(s):  
Maria Ulfa ◽  
Kris Sisca Aristia ◽  
Didik Prasetyoko
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Templating Method ◽  
Silica Materials ◽  
Mesoporous Silica Materials

scholarly journals Sol–gel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system

2011 ◽  
Vol 61 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Corine Tourne-Peteilh ◽  
Sylvie Begu ◽  
Dan A. Lerner ◽  
Anne Galarneau ◽  
Ugo Lafont ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sol Gel ◽  
One Pot ◽  
One Pot Synthesis ◽  
Silica Materials ◽  
Mesoporous Silica Materials

Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica

2008 ◽  
Vol 391 ◽  
pp. 169-184 ◽  
Author(s):  
T. López ◽  
Fernando Edgar Krötzsch ◽  
E. Ortiz Islas ◽  
M. Alvarez Lemus ◽  
E. Balsadella ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Surface Area ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ordered Mesoporous Silica ◽  
Ordered Mesoporous ◽  
Vis Spectroscopy ◽  
Silica Materials ◽  
Inflammatory Infiltrates

Mesoporous silica type SBA-15 has high specific surface area, well ordered pores and renders larges volumes, reasons for its potential use in controlled drug delivery system; in addition its non toxic nature and good biocompatibility. The aim of this work is to determine the feasibility of loading collagen-polyvinylpyrrolidone (collagen-PVP) molecules into Biocompatible Nanostructured Ordered Mesoporous Silica (BINOM-Silica). Collagen-PVP has several medical uses, such as fibrolytic activity and tissue regeneration. Therefore, this BINOM-Silica/collagen- PVP material could be used as drug delivery system for hypertrophic scarring. Different BINOMSilica materials were prepared using a triblock copolymer in an acid medium and stabilized at 557°C and later, collagen-PVP was loaded into the material. The small angle powder X-ray diffraction patterns of BINOM-Silica materials, in some cases, indicate the existence of a high degree of hexagonal mesoscopic organization. The nitrogen sorption isotherms are type IV typical of mesoporous materials with large surface area. In vitro release of collagen-PVP was carried out by mean of UV/VIS spectroscopy. The cumulative release profiles of Silica-collagen PVP in distilled water indicate a two step release, an initial fast release and a relatively slow subsequent release, indicating an appropriate delivery of collagen-PVP for therapeutic administration. BINOMSilica/ collagen-PVP intradermical administration stimulated inflammatory infiltrates only in an acute phase (day 3), demonstrating that silica materials and their combination with chemical and biological drugs could be safe for therapeutics. The absence of inflammatory infiltrates at day 7 suggested an appropriate integration of BINOM-Silica/collagen-PVP into the tissue. These results indicate that we obtained biocompatible nanostructured ordered mesoporous silica materials useful for delivery systems.

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document