scholarly journals Effectivenes of K2CO3 and KHCO3 as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro

2018 ◽  
Author(s):  
E. Budianto ◽  
A. Hidayatullah
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Vinyl Pyrrolidone ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

scholarly journals OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (6) ◽  
pp. 65 ◽  
Author(s):  
Mirmeera Girish Niharika ◽  
Kannan Krishnamoorthy ◽  
Madhukar Akkala
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
In Vivo Studies ◽  
Gastric Retention ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

The principal objective behind the writing of this article on the floating drug delivery system (FDDS) was to systematize the recent literature with the core process of floatation in acquiring gastric retention. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The novel methodologies in FDDS include approaches to design a single unit and multiple-unit floating systems, the physiological and formulation variability affecting gastric retention along with the use of recently invented and developed polymers. This review also focuses on various in vitro techniques and in vivo studies in view of performance and application of floating systems. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. This review also throws light on different techniques used in developing floating dosage forms along with current and novel advancements.

DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ACECLOFENAC

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (09) ◽  
pp. 63-66
Author(s):  
J. C Rathi ◽  
◽  
V. Rathi ◽  
S. Tamizharasi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Entrapment Efficiency ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Drug Entrapment Efficiency ◽  
Floating Drug Delivery System ◽  
Central Composite

The objective of the present investigation is to attain optimized floating drug delivery system for aceclofenac by determining the effects of some important factors for the prolongation of gastric residence time. Floating microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A central composite design was applied to optimize the formulation. An appropriate balance between the levels of the polymer and stirring speed was imperative to acquire maximum drug entrapment efficiency, sustained release of the drug, floating ability and adequate particle size.

scholarly journals Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization

2014 ◽  
Vol 50 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Venkata Srikanth Meka ◽  
Senthil Rajan Dharmanlingam ◽  
Venkata Ramana Murthy Kolapalli
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Release Mechanism ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physico-chemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate kinetics with non-Fickian diffusion mechanism. The optimized formulation was characterised with FTIR studies and observed no interaction between the drug and the polymers.

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