scholarly journals Early pathological characterization of murine dissecting abdominal aortic aneurysms

2018 ◽  
Vol 2 (4) ◽  
pp. 046106 ◽  
Author(s):  
Evan H. Phillips ◽  
Adam H. Lorch ◽  
Abigail C. Durkes ◽  
Craig J. Goergen
2005 ◽  
Vol 201 (3) ◽  
pp. S103
Author(s):  
Celine Buckley ◽  
Monica Pagano ◽  
Terri Ennis ◽  
Robert Thompson

2019 ◽  
Vol 85 ◽  
pp. 126-133 ◽  
Author(s):  
Niels J. Petterson ◽  
Emiel M.J. van Disseldorp ◽  
Marc R.H.M. van Sambeek ◽  
Frans N. van de Vosse ◽  
Richard G.P. Lopata

Author(s):  
Ender A. Finol ◽  
Shoreh Hajiloo ◽  
Keyvan Keyhani ◽  
David A. Vorp ◽  
Cristina H. Amon

Abdominal Aortic Aneurysms (AAAs) are characterized by a continuous dilation of the infrarenal segment of the abdominal aorta. Despite significant improvements in surgical procedures and imaging techniques, the mortality and morbidity rates associated with untreated ruptured AAAs are still outrageously high. AAA disease is a health risk of significant importance since this kind of aneurysm is mostly asymptomatic until its rupture, which is frequently a lethal event with an overall mortality rate in the 80% to 90% range. From a purely biomechanical viewpoint, aneurysm rupture is a phenomenon that occurs when the mechanical stress acting on the dilating inner wall exceeds its failure strength. Since the internal mechanical forces are maintained by the dynamic action of blood flowing in the aorta, the quantification of the hemodynamics of AAAs is essential for the characterization of their biomechanical environment.


2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
Marcus R Makowski ◽  
Andrea J Wiethoff ◽  
Hans U Ebersberger ◽  
Christian H Jansen ◽  
Ulrike Blume ◽  
...  

2018 ◽  
Vol 315 (3) ◽  
pp. H540-H549 ◽  
Author(s):  
Gerhard A. Holzapfel ◽  
Ray W. Ogden

The microstructure of arteries, consisting, in particular, of collagen, elastin, and vascular smooth muscle cells, plays a very significant role in their biomechanical response during a cardiac cycle. In this article, we highlight the microstructure and the contributions of each of its components to the overall mechanical behavior. We also describe the changes of the microstructure that occur as a result of abdominal aortic aneurysms and disease, such as atherosclerosis. We also focus on how the passive and active constituents are incorporated into a mathematical model without going into detail of the mathematical formulation. We conclude by mentioning open problems toward a better characterization of the biomechanical aspects of arteries that will be beneficial for a better understanding of cardiovascular pathophysiology.


Sign in / Sign up

Export Citation Format

Share Document