Research of possibility of UV-spectroscopy method and luminescent analysis for detecting fatty pollution in chladon

AbstractUV-spectroscopy method is used to study the influence ofdifferent varying growth parameters (growth rate, crystallization temperature, pH of the solution, complexating additions) on the absorption spectra of KH2PO4 crystals. It is found that the minimal value of the absorption coefficient (k ˜ 0.01–0.02cm−1)may be achieved under the following growth conditions: 1) crystallization temperature ˜ 55°C, 2) growth rate ˜ 1mm/24hrs, 3)pH = 4.

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EFFECT OF 2-HYDROXYPROPYL- β -CYCLODEXTRIN ON SOLUBILITY OF NOVEL CYTOTOXIC COMPOUNDS

IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA ◽

10.6060/tcct.20165903.5318 ◽

2018 ◽

Vol 59 (3) ◽

pp. 26

Author(s):

Marina V. Ol’khovich ◽

Angelica V. Sharapova ◽

Svetlana V. Blokhina

Keyword(s):

Thermodynamic Parameters ◽

Stability Constants ◽

Inclusion Compounds ◽

Inclusion Compound ◽

Uv Spectroscopy ◽

Spectroscopy Method ◽

Component Ratio ◽

Temperature Range ◽

Cytotoxic Compounds

Complexation processes in the systems of 2-hydroxylpropyl-β-cyclodextrin − cytotoxic substances within the temperature range of 293 – 315 К were studied by the UV-spectroscopy method. It was proved that complexation leads to the formation of supramolecular inclusion compounds with 1:1 component ratio. Stability constants of the complexes and thermodynamic parameters of the formation of the inclusion compound 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl)methanol were calculated. The obtained complex of 2-hydroxylpropyl-β-cyclodextrin – tris(1-pentyl-1Н-indol-3-yl) methylium chloride was found to be unstable.

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QUANTIFICATION USING ULTRAVIOLET SPECTROSCOPY METHOD AND IN VITRO STABILITY STUDY OF NANOVESICULAR SYSTEM CONTAINING PHYTIC ACID

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i8.26671 ◽

2018 ◽

Vol 11 (8) ◽

pp. 374

Author(s):

Malti Arya ◽

Krishna P Gupta ◽

Shubhini A Saraf

Keyword(s):

Zeta Potential ◽

Phytic Acid ◽

Uv Spectroscopy ◽

Research Work ◽

Stability Study ◽

Spectroscopy Method ◽

Stability Testing ◽

Ich Guidelines ◽

The Stability

Objective: The quantification of drug and stability of nanoparticulate delivery systems is one of the major apprehensions in biomedical applications. The present research work was attempted to quantify phytic acid by utilizing ultraviolet (UV) spectroscopy method and to evaluate the stability of nanovesicular (niosomes) system containing phytic acid.Methods: Niosomes containing phytic acid were developed by thin-film hydration method. Nanoformulation was subjected to stability testing as per the International Council for Harmonisation (ICH) guidelines. The formulation was stored at 30°C±2°C and 65%±5% RH, samples were withdrawn at 15th, 30th, 60th, 90th, 120th, and 180th day of analysis and examined for the integrity of vesicular/particle size, polydispersity index, zeta potential, and percent encapsulation efficiency.Results: Prepared nanoformulation displayed a straight line (y=mx+c) equation of y=−0.0309x+1.0413. Optimized batch of niosomes, which was prepared including dicetylphosphate showed zeta potential value of −36±0.36. Stability study showed that prepared niosomal formulation was stable up to 180 days at room temperature.Conclusion: Findings of the current research work suggested that UV spectroscopy method can be effectively used for the quantification of phytic acid and niosomal formulation of phytic acid. The formulation was found to be stable as per the ICH guidelines for stability testing.

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