scholarly journals A nonlinear resonant mass sensor with enhanced sensitivity and resolution incorporating compressed bistable beam

2018 ◽  
Vol 124 (16) ◽  
pp. 164503 ◽  
Author(s):  
Jian Zhao ◽  
Chen Sun ◽  
Najib Kacem ◽  
Hongxi Wang ◽  
Renjing Gao ◽  
...  
Keyword(s):  
Mass Sensor ◽  
Enhanced Sensitivity

Eyes and ears: Rejection and enhanced sensitivity to auditory and visual social cues

2003 ◽  
Author(s):  
Cynthia L. Pickett ◽  
Wendi L. Gardner ◽  
Megan Knowles
Keyword(s):  
Social Cues ◽  
Enhanced Sensitivity

ALCOHOL-PREFERRING AA RATS EXPRESS ENHANCED SENSITIVITY TO STIMULATORY EFFECTS OF MORPHINE

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 461-464 ◽  
Author(s):  
A. Honkanen ◽  
E.R. Korpi ◽  
L. Ahtee
Keyword(s):  
Enhanced Sensitivity

Mass Spectrometry for Proteomics and Recent Developments in ESI, MALDI and other Ionization Methodologies

2019 ◽  
Vol 16 (4) ◽  
pp. 267-276
Author(s):  
Qurat ul Ain Farooq ◽  
Noor ul Haq ◽  
Abdul Aziz ◽  
Sara Aimen ◽  
Muhammad Inam ul Haq
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
New Technologies ◽  
Protein Complexes ◽  
Imaging Techniques ◽  
Desorption Electrospray Ionization ◽  
High Throughput Analysis ◽  
Enhanced Sensitivity ◽  
Recent Developments ◽  
The Way

Background: Mass spectrometry is a tool used in analytical chemistry to identify components in a chemical compound and it is of tremendous importance in the field of biology for high throughput analysis of biomolecules, among which protein is of great interest. Objective: Advancement in proteomics based on mass spectrometry has led the way to quantify multiple protein complexes, and proteins interactions with DNA/RNA or other chemical compounds which is a breakthrough in the field of bioinformatics. Methods: Many new technologies have been introduced in electrospray ionization (ESI) and Matrixassisted Laser Desorption/Ionization (MALDI) techniques which have enhanced sensitivity, resolution and many other key features for the characterization of proteins. Results: The advent of ambient mass spectrometry and its different versions like Desorption Electrospray Ionization (DESI), DART and ELDI has brought a huge revolution in proteomics research. Different imaging techniques are also introduced in MS to map proteins and other significant biomolecules. These drastic developments have paved the way to analyze large proteins of >200kDa easily. Conclusion: Here, we discuss the recent advancement in mass spectrometry, which is of great importance and it could lead us to further deep analysis of the molecules from different perspectives and further advancement in these techniques will enable us to find better ways for prediction of molecules and their behavioral properties.

scholarly journals Enhanced sensitivity RNA gel loading buffer that enables efficient RNA separation on native gels

BioTechniques ◽  
2004 ◽  
Vol 36 (2) ◽  
pp. 334-336 ◽  
Author(s):  
Keqin Gregg ◽  
Wenli Zhou ◽  
Wan Ji ◽  
Sara Davis
Keyword(s):  
Enhanced Sensitivity

High resonant mass sensor evaluation: An effective method

2005 ◽  
Vol 76 (11) ◽  
pp. 115101 ◽  
Author(s):  
Yakov M. Tseytlin
Keyword(s):  
Mass Sensor

scholarly journals Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arkadiusz Miazek ◽  
Michał Zalas ◽  
Joanna Skrzymowska ◽  
Bryan A. Bogin ◽  
Krzysztof Grzymajło ◽  
...  
Keyword(s):  
Neuronal Development ◽  
Neuronal Membrane ◽  
Post Translational Modifications ◽  
Calcium Dependent ◽  
Enhanced Sensitivity ◽  
Embryonic Lethal ◽  
Progressive Ataxia ◽  
Substrate Level ◽  
Age Dependent ◽  
Excessive Activation

AbstractThe neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational modifications impinge on spectrin, the major component of the MPS, but their role remains poorly understood. One modification targeting spectrin is cleavage by calpains, a family of calcium-activated proteases. Spectrin cleavage is regulated by activated calpain, but also by the calcium-dependent binding of calmodulin (CaM) to spectrin. The physiologic significance of this balance between calpain activation and substrate-level regulation of spectrin cleavage is unknown. We report a strain of C57BL/6J mice harboring a single αII spectrin point mutation (Sptan1 c.3293G > A:p.R1098Q) with reduced CaM affinity and intrinsically enhanced sensitivity to calpain proteolysis. Homozygotes are embryonic lethal. Newborn heterozygotes of either gender appear normal, but soon develop a progressive ataxia characterized biochemically by accelerated calpain-mediated spectrin cleavage and morphologically by disruption of axonal and dendritic integrity and global neurodegeneration. Molecular modeling predicts unconstrained exposure of the mutant spectrin’s calpain-cleavage site. These results reveal the critical importance of substrate-level regulation of spectrin cleavage for the maintenance of neuronal integrity. Given that excessive activation of calpain proteases is a common feature of neurodegenerative disease and traumatic encephalopathy, we propose that damage to the spectrin MPS may contribute to the neuropathology of many disorders.

Zero-valent iron nanomaterial Fe0@Fe2MnO4 for ultrasensitive electroanalysis of As(III): Fe0 influenced surficial redox potential

2021 ◽  
Author(s):  
Meng Yang ◽  
Feng Xie ◽  
Shan-Shan Li ◽  
Chu-Hong Lin ◽  
Xing-Jiu Huang ◽  
...  
Keyword(s):  
Redox Potential ◽  
Electrochemical Detection ◽  
Zero Valent Iron ◽  
Enhanced Sensitivity

A novel zero-valent iron nanomaterial (Fe0@Fe2MnO4) was synthesized and achieved an ultrasensitive electrochemical detection of As(III). It was found that the enhanced sensitivity is attributed to the surficial catalytic redox...

Optical temperature sensing based on upconversion nanoparticles with enhanced sensitivity via dielectric superlensing modulation

2021 ◽  
Vol 56 (17) ◽  
pp. 10438-10448
Author(s):  
Mei Lin ◽  
Shengbin Cheng ◽  
Xiaofeng Wu ◽  
Shiping Zhan ◽  
Yunxin Liu
Keyword(s):  
Temperature Sensing ◽  
Upconversion Nanoparticles ◽  
Enhanced Sensitivity
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