scholarly journals An artificial placenta type microfluidic blood oxygenator with double-sided gas transfer microchannels and its integration as a neonatal lung assist device

2018 ◽  
Vol 12 (4) ◽  
pp. 044101 ◽  
Author(s):  
Mohammadhossein Dabaghi ◽  
Gerhard Fusch ◽  
Neda Saraei ◽  
Niels Rochow ◽  
John L. Brash ◽  
...  
Keyword(s):  
Gas Transfer ◽  
Assist Device ◽  
Blood Oxygenator ◽  
Neonatal Lung

Study on the Intravenous Lung Assist Device (ILAD) Using PZT Actuators and PVDF Sensors

2008 ◽  
Vol 381-382 ◽  
pp. 353-356
Author(s):  
Gi Beum Kim ◽  
S.J. Kim ◽  
Y.C. Lee ◽  
C.U. Hong ◽  
H.S. Kang ◽  
...  
Keyword(s):  
Transfer Rate ◽  
Semipermeable Membrane ◽  
Gas Transfer ◽  
Scaling Analysis ◽  
Membrane Oxygenator ◽  
Assist Device ◽  
Dimensionless Groups ◽  
Membrane Vibrations ◽  
Insight Into ◽  
Membrane Vibration

The purpose of this study was to investigate the effect of vibration device in gas transfer rate for usage as intravenous lung assist device. Specific attention was focused on the effect of membrane vibration. Quantitative experimental measurements were performed to evaluate the performance of the device, and to identify membrane vibration dependence on hemolysis. Scaling analysis was then used to infer the dimensionless groups that correlate the performance of a vibrated hollow tube membrane oxygenator. The experimental design and procedure are then given for a device for assessing the effectiveness of membrane vibrations. This ILAD is used to provide some insight into how wall vibrations might enhance the performance of an intravascular lung assist device. The time and the frequency response of PVDF sensor were investigated through various frequencies in the ILAD. In these devices, the flow of blood and the source of oxygen were separated by a semipermeable membrane allows oxygen to diffuse into and out of the f1uid, respectively. The results of experiments have shown vibrating ILAD performs effectively.

Gas transfer and hemolysis in an intravascular lung assist device using a PZT actuator

2009 ◽  
Vol 10 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Chul-Un Hong ◽  
Jeong-Mi Kim ◽  
Min-Ho Kim ◽  
Seong-Jong Kim ◽  
Hyung-Sub Kang ◽  
...  
Keyword(s):  
Gas Transfer ◽  
Assist Device ◽  
Pzt Actuator

scholarly journals Development of a biomimetic microfluidic oxygen transfer device

Lab on a Chip ◽  
2016 ◽  
Vol 16 (17) ◽  
pp. 3227-3234 ◽  
Author(s):  
A. A. Gimbel ◽  
E. Flores ◽  
A. Koo ◽  
G. García-Cardeña ◽  
J. T. Borenstein
Keyword(s):  
Gas Exchange ◽  
Oxygen Transfer ◽  
Gas Transfer ◽  
Blood Gas ◽  
Endothelial Lining ◽  
Assist Device ◽  
Blood Compartment ◽  
Exchange Properties ◽  
Transfer Device

A microfluidic respiratory assist device is demonstrated, with blood gas transfer as a function of the size and number of transfer layers demonstrated, along with anti-coagulation and gas exchange properties of a confluent endothelial lining of the blood compartment.

An Integrated Array of Microfluidic Oxygenators as a Neonatal Lung Assist Device: In Vitro Characterization and In Vivo Demonstration

2014 ◽  
Vol 38 (10) ◽  
pp. 856-866 ◽  
Author(s):  
Niels Rochow ◽  
Asmaa Manan ◽  
Wen-I Wu ◽  
Gerhard Fusch ◽  
Shelley Monkman ◽  
...  
Keyword(s):  
Assist Device ◽  
In Vitro Characterization ◽  
Neonatal Lung

scholarly journals A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress

2020 ◽  
Author(s):  
Mohammadhossein Dabaghi ◽  
Niels Rochow ◽  
Neda Saraei ◽  
Gerhard Fusch ◽  
Shelley Monkman ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Systemic Circulation ◽  
Newborn Piglet ◽  
Pure Oxygen ◽  
Respiratory Morbidity ◽  
Preterm Neonates ◽  
Successful Operation ◽  
Assist Device ◽  
Human Infants ◽  
Neonatal Lung

AbstractPremature neonates suffer from respiratory morbidity as their lungs are immature and current supportive treatment such as mechanical ventilation or extracorporeal membrane oxygenation (ECMO) cause iatrogenic injuries. A non-invasive and biomimetic concept known as the “artificial placenta” would be beneficial to overcome complications associated with the current respiratory support of preterm infants. Here, a pumpless oxygenator connected to the systemic circulation supports the lung function to relieve respiratory distress. In this paper, we demonstrate the first successful operation of a microfluidic, artificial placenta type neonatal lung assist device (LAD) on a newborn piglet model which is the closest representation of preterm human infants. This LAD has high oxygenation capability in both pure oxygen and room air as the sweep gas. It was able to relieve the respiratory distress that the newborn piglet was put under during experimentation, repeatedly and over significant duration of time. These findings indicate that this LAD has potential application as a biomimetic artificial placenta to support respiratory needs of preterm neonates.

scholarly journals Formulation of Generalized Mass Transfer Correlations for Blood Oxygenator Design

2017 ◽  
Vol 139 (3) ◽  
Author(s):  
Kenny W. Q. Low ◽  
Raoul Van Loon ◽  
Samuel A. Rolland ◽  
Johann Sienz
Keyword(s):  
Carbon Dioxide ◽  
Mass Transfer ◽  
Sherwood Number ◽  
Concentration Field ◽  
Transverse Flow ◽  
Gas Transfer ◽  
Carbon Dioxide Transport ◽  
Blood Oxygenator ◽  
Geometrical Features ◽  
Local Mass Transfer

This paper numerically investigates non-Newtonian blood flow with oxygen and carbon dioxide transport across and along an array of uniformly square and staggered arranged fibers at various porosity (ε) levels, focussing on a low Reynolds number regime (Re < 10). The objective is to establish suitable mass transfer correlations, expressed in the form of Sherwood number (Sh = f(ε, Re, Sc)), that identifies the link from local mass transfer investigations to full-device analyses. The development of a concentration field is initially investigated and expressions are established covering the range from a typical deoxygenated condition up to a full oxygenated condition. An important step is identified where a cut-off point in those expressions is required to avoid any under- or over-estimation on the Sherwood number. Geometrical features of a typical commercial blood oxygenator is adopted and results in general show that a balance in pressure drop, shear stress, and mass transfer is required to avoid potential blood trauma or clotting formation. Different definitions of mass transfer correlations are found for oxygen/carbon dioxide, parallel/transverse flow, and square/staggered configurations, respectively. From this set of correlations, it is found that transverse flow has better gas transfer than parallel flow which is consistent with reported literature. The mass transfer dependency on fiber configuration is observed to be pronounced at low porosity. This approach provides an initial platform when one is looking to improve the mass transfer performance in a blood oxygenator without the need to conduct any numerical simulations or experiments.

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