Sub-acute toxicological effects of Jobelyn® on pregnant albino rats

2018 ◽  
Author(s):  
Abiodun Humphrey Adebayo ◽  
Omolara Faith Yakubu ◽  
Godwin Eneji Egbung ◽  
Olabisi Ibidun Williams ◽  
Olajuwon Okubena
Keyword(s):  
Albino Rats ◽  
Toxicological Effects

scholarly journals Toxicological Effects of Para-Phenylenediamine on kidneys of Female Albino Rats.

2021 ◽  
Vol 0 (0) ◽  
pp. 1-12
Author(s):  
omima mohamed ◽  
nermine hassan ◽  
islam mitwalli ◽  
asmaa hussein
Keyword(s):  
Albino Rats ◽  
Toxicological Effects

Lactic acid bacteria bio-detoxified aflatoxins contaminated cereals, ameliorate toxicological effects and improve haemato-histological parameters in albino rats

Toxin Reviews ◽  
2020 ◽  
pp. 1-12
Author(s):  
Olukayode Adebola Ibitoye ◽  
Oladipo Oladiti Olaniyi ◽  
Clement Olusola Ogidi ◽  
Bamidele Juliet Akinyele
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Albino Rats ◽  
Toxicological Effects

Entomotoxic effects of synthesized aluminum oxide nanoparticles against Sitophilus oryzae and their toxicological effects on albino rats

2021 ◽  
pp. 074823372110350
Author(s):  
Tamer Ismail ◽  
Mohamed A Salama ◽  
Mostafa Elabiary
Keyword(s):  
Aluminum Oxide ◽  
Insect Pests ◽  
Sitophilus Oryzae ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Histopathological Analysis ◽  
Dependent Manner ◽  
Aluminum Oxide Nanoparticles ◽  
Toxicological Effects ◽  
Stored Product Pest

Recently, nanoparticles are emerging as a potential alternative to synthetic pesticides for protection against stored-product insect pests, such as the rice weevil Sitophilus oryzae; however, the toxic effects of nanoparticles on nontarget organisms are not yet understood. Therefore, we investigated the insecticidal effects of synthesized aluminum oxide nanoparticles (Al2O3-NPs) on S. oryzae, as well as their potential toxicity in albino rats. S. oryzae mortality increased as the period of Al2O3-NP exposure increased; 100% mortality was reached at 8000 mg Al2O3-NPs/kg of wheat grain after 7 days of exposure. After 60 days of exposure, all tested Al2O3-NPs concentrations (1000, 2000, 4000, and 8000 mg/kg grain) significantly reduced the number of S. oryzae offspring in a dose-dependent manner. In albino rats, exposure to the LC90 of Al2O3-NPs in a treated diet caused a significant decrease in total body weight and an increase in liver weight in a subacute toxicity test. Moreover, Al2O3-NP treatment elevated the levels of alanine aminotransferase, aspartate aminotransferase, and creatinine in exposed rats relative to control rats, while the uric acid levels of treated rats decreased. Histopathological analysis also revealed various hepatic and renal lesions in treated rats. In summary, although Al2O3-NPs have insecticidal effects, they also have hazardous toxicological effects on rats. Therefore, if Al2O3-NPs are used in the current powder form to protect stored products, they may cause adverse effects to workers and consumers. Further research will be required to develop new nanoformulations with increased safety and potency before these nanoparticles can be used in stored-product pest control.

Toxicological effects of cadmium during pregnancy in Wistar albino rats

2014 ◽  
Vol 6 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Jonah Sydney Aprioku ◽  
Barikpoar Ebenezer ◽  
Maxwell Azubuike Ijomah
Keyword(s):  
Albino Rats ◽  
Toxicological Effects ◽  
Wistar Albino Rats

scholarly journals Toxicological Effect of Euphorbia heterophylla Linn

2021 ◽  
pp. 1-15
Author(s):  
J. K. Kone ◽  
A. K. Onifade
Keyword(s):  
White Blood Cells ◽  
Clinical Manifestations ◽  
Negative Control Group ◽  
Negative Control ◽  
Hot Water ◽  
Control Group ◽  
Albino Rats ◽  
Toxicological Effect ◽  
Toxicological Effects ◽  
Animal House

Euphorbia heterophylla has been reported to possess enormous medicinal benefits hence there is a need for holistic research on its toxicological effects. Four different solvents (cold and hot water, chloroform and 80% methanol) were used to extract the aerial parts of Euphorbia heterophylla Linn. Experimental albino rats were obtained from Federal University of Technology Akure’s Microbiology Department Animal House. Toxicological analysis of Euphorbia heterophylla extracts was carried out on the experimental albino rats. The animals were grouped into thirteen with three rats in a group different concentrations of the extracts were administered orally to different groups of the rats for a period of two weeks (14 days). Sterile distilled water was administered to the negative control group. During the 14 days of extracts administration, the animals were observed for clinical manifestations like salivation, nervousness, imitability, itching of the nose and diarrhoea. After the expiration of the two weeks, the animals were sacrificed and vital organs like heart, liver, kidney and intestine were harvested and examined for any degenerative changes and lesions. Blood samples were collected before and after the administration of the extracts to check for blood parameters (Packed Cell Volume (PCV), white blood cell count (total and differential), erythrocyte sedimentation rate (ESR) and haemoglobin (Hb) estimation. The toxicological results of the extracts showed various degrees of abnormalities detected in the histopathological sections of the intestine, kidney and the heart. It was found that all the extracts at different concentrations burnt the intestinal walls of all the animals tested. There were significant reductions in the total white blood cells (WBC) and neutrophil counts while there was a significant increase in the lymphocytes count after the administration of the extracts. The findings of this study revealed that Euphorbia heterophylla had toxicological effects on the albino rats organs but increases there lymphocytes count, boosting their immune system, however advance researches to eliminate the toxic phytochemicals from the extract is recommended.

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