scholarly journals Estimation of the plasma blob occurrence rate

2018 ◽  
Vol 25 (1) ◽  
pp. 012315 ◽  
Author(s):  
R. Häcker ◽  
G. Fuchert ◽  
D. Carralero ◽  
P. Manz
Keyword(s):  
Occurrence Rate ◽  
Plasma Blob

Repurposing N,N-Dimethylacetamide (DMA), a Pharmaceutical Excipient, as a Prototype Novel Anti-inflammatory Agent for the Prevention and/or Treatment of Preterm Birth

2018 ◽  
Vol 24 (9) ◽  
pp. 989-992 ◽  
Author(s):  
Samir Gorasiya ◽  
Juliet Mushi ◽  
Ryan Pekson ◽  
Sabesan Yoganathan ◽  
Sandra E. Reznik
Keyword(s):  
Preterm Birth ◽  
Ex Vivo ◽  
The United States ◽  
Occurrence Rate ◽  
Pharmaceutical Excipient ◽  
Ongoing Work ◽  
Exciting Line ◽  
Pregnant Mice

Background: Preterm birth (PTB), or birth that occurs before 37 weeks of gestation, accounts for the majority of perinatal morbidity and mortality. As of 2016, PTB has an occurrence rate of 9.6% in the United States and accounts for up to 18 percent of births worldwide. Inflammation has been identified as the most common cause of PTB, but effective pharmacotherapy has yet to be developed to prevent inflammation driven PTB. Our group has discovered that N,N-dimethylacetamide (DMA), a readily available solvent commonly used as a pharmaceutical excipient, rescues lipopolysaccharide (LPS)-induced timed pregnant mice from PTB. Methods: We have used in vivo, ex vivo and in vitro approaches to investigate this compound further. Results: Interestingly, we found that DMA suppresses cytokine secretion by inhibiting nuclear factor-kappa B (NF-κB). In ongoing work in this exciting line of investigation, we are currently investigating structural analogs of DMA, some of them novel, to optimize this approach focused on the inflammation associated with PTB. Conclusion: Successful development of pharmacotherapy for the prevention of PTB rests upon the pursuit of multiple strategies to solve this important clinical challenge.

scholarly journals Understanding the unimodal distributions of cancer occurrence rates: it takes two factors for a cancer to occur

2020 ◽  
Author(s):  
Shuang Qiu ◽  
Zheng An ◽  
Renbo Tan ◽  
Ping-an He ◽  
Jingjing Jing ◽  
...  
Keyword(s):  
Occurrence Rate ◽  
Cancer Drug ◽  
Proliferative Potential ◽  
Cancer Type ◽  
Cancer Occurrence ◽  
Important Relationship ◽  
Age Regression ◽  
Age Dependent ◽  
Two Factors ◽  
Realistic Possibility

Abstract Data from the SEER reports reveal that the occurrence rate of a cancer type generally follows a unimodal distribution over age, peaking at an age that is cancer-type specific and ranges from 30+ through 70+. Previous studies attribute such bell-shaped distributions to the reduced proliferative potential in senior years but fail to explain why some cancers have their occurrence peak at 30+ or 40+. We present a computational model to offer a new explanation to such distributions. The model uses two factors to explain the observed age-dependent cancer occurrence rates: cancer risk of an organ and the availability level of the growth signals in circulation needed by a cancer type, with the former increasing and the latter decreasing with age. Regression analyses were conducted of known occurrence rates against such factors for triple negative breast cancer, testicular cancer and cervical cancer; and all achieved highly tight fitting results, which were also consistent with clinical, gene-expression and cancer-drug data. These reveal a fundamentally important relationship: while cancer is driven by endogenous stressors, it requires sufficient levels of exogenous growth signals to happen, hence suggesting the realistic possibility for treating cancer via cleaning out the growth signals in circulation needed by a cancer.

scholarly journals Investigation of Low Latitude Spread-F Triggered by Nighttime Medium-Scale Traveling Ionospheric Disturbance

2021 ◽  
Vol 13 (5) ◽  
pp. 945
Author(s):  
Zhongxin Deng ◽  
Rui Wang ◽  
Yi Liu ◽  
Tong Xu ◽  
Zhuangkai Wang ◽  
...  
Keyword(s):  
Ionospheric Disturbance ◽  
Phase Speed ◽  
Morphological Processing ◽  
Wave Number ◽  
Occurrence Rate ◽  
Electron Content ◽  
Low Latitude ◽  
Total Electron ◽  
Medium Scale ◽  
Spread F

In the current study, we investigated the mechanism of medium-scale traveling ionospheric disturbance (MSTID) triggering spread-F in the low latitude ionosphere using ionosonde observation and Global Navigation Satellite System-Total Electron Content (GNSS-TEC) measurement. We use a series of morphological processing techniques applied to ionograms to retrieve the O-wave traces automatically. The maximum entropy method (MEM) was also utilized to obtain the propagation parameters of MSTID. Although it is widely acknowledged that MSTID is normally accompanied by polarization electric fields which can trigger Rayleigh–Taylor (RT) instability and consequently excite spread-F, our statistical analysis of 13 months of MSTID and spread-F occurrence showed that there is an inverse seasonal occurrence rate between MSTID and spread-F. Thus, we assert that only MSTID with certain properties can trigger spread-F occurrence. We also note that the MSTID at night has a high possibility to trigger spread-F. We assume that this tendency is consistent with the fact that the polarization electric field caused by MSTID is generally the main source of post-midnight F-layer instability. Moreover, after thorough investigation over the azimuth, phase speed, main frequency, and wave number over the South America region, we found that the spread-F has a tendency to be triggered by nighttime MSTID, which is generally characterized by larger ΔTEC amplitudes.

scholarly journals Contributions of Hypoxia-Awareness Training to the Familiarization of Personal Symptoms for Occupational Safety in the Flight Environment

2021 ◽  
Vol 18 (6) ◽  
pp. 2904
Author(s):  
Kwo-Tsao Chiang ◽  
Min-Yu Tu ◽  
Chao-Chien Cheng ◽  
Hsin-Hui Chen ◽  
Wun-Wei Huang ◽  
...  
Keyword(s):  
Occupational Safety ◽  
Safety Issue ◽  
Hot Flashes ◽  
Occurrence Rate ◽  
Flight Safety ◽  
Awareness Training ◽  
The Past ◽  
Individual Memory ◽  
The Individual ◽  
Poor Concentration

Hypoxia remains a flight-safety issue in terms of aviation medicine. Hypoxia-awareness training has been used to help aircrew members recognize personal hypoxia symptoms. There is still no study, as yet, to establish the association of within-subject data between inflight hypoxia events and the altitude chamber. The main purpose of our study was to use paired subjects’ data on inflight hypoxia symptoms compared with those experienced during training. A questionnaire was developed to obtain information on military aircrew members in 2018. Among 341 subjects, 46 (13.49%) suffered from inflight hypoxia. The majority of the subjects detected ongoing inflight hypoxia on the basis of their previous experience with personal hypoxia symptoms or sensations in previous chamber flights. Of the top five hypoxia symptoms, the data revealed that hot flashes, poor concentration, and impaired cognitive function appeared both during the inflight events and during the hypoxia-awareness training. The occurrence rate of hypoxia symptoms was found to not be significantly different between the in-flight events and the past chamber flights through an analysis of within-subject data. Because the individual memory had faded away over time, fresher hypoxia awareness training is still mandatory and valuable to recall personal hypoxia experience for military aircrew members.

scholarly journals The occurrence rate and clinical application of Osteo-line on the femur neck

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mingchen Zou ◽  
Haotian Wu ◽  
Shuangquan Yao ◽  
Dong Ren ◽  
Song Liu ◽  
...  
Keyword(s):  
Clinical Application ◽  
Visual Inspection ◽  
Occurrence Rate ◽  
Control Group ◽  
Leg Length ◽  
X Ray ◽  
The Third ◽  
Femur Neck ◽  
Medical University ◽  
Experimental Group

Abstract Background This study was done to observe the incidence of Osteo-line on the femur neck and to explore the clinical application of Osteo-line in osteotomy. Methods Eighty-nine adult femur specimens were selected to observe the incidence of Osteo-line on the femur neck. From August 2015 to January 2019, a total of 278 patients who completed unilateral hip arthroplasty at the Third Hospital of Hebei Medical University were retrospectively included. Patients who accepted osteotomy via Osteo-line on the femur neck were defined as the experimental group (n = 139), and patients who accepted osteotomy via traditional method (The femoral distance 1.5 cm above the trochanter was retained for osteotomy by visual inspection.) were defined as the control group (n = 139). According to the postoperative pelvic X-ray, Photoshop was used to evaluate the leg length discrepancy (LLD) by the CFR-T-LT method. Results Among the 89 specimens, the incidence of anterior Osteo-line was 75.28%, and the incidence of posterior Osteo-line was 100%. According to the clinical application results, the incidence of anterior Osteo-line on the femur neck was 80%, and the incidence of posterior Osteo-line was 100%. The Osteo-line was clearer than those on the femoral specimens. Twenty-six cases had LLD greater than 1 cm (9.29%), including 2 cases in the experimental group and 24 cases in the control group. The average postoperative LLD in the experimental group (0.19 ± 0.38 mm) was significantly shorter than in the control group (0.54 ± 0.51 mm)(P = 0.005). Conclusion The incidence of Osteo-line on the femur neck was high, and patients who accepted osteotomy via Osteo-line on the femur neck can achieve shorter postoperative LLD than the control group.

scholarly journals Evaluation of Prognostic Factors for Palatal Fistulas after Cleft Lip and Palate Surgery in a North-Western Romanian Population over a 10-Year Period

2021 ◽  
Vol 18 (14) ◽  
pp. 7305
Author(s):  
Daiana Antoaneta Opris ◽  
Horia Opris ◽  
Cristian Dinu ◽  
Simion Bran ◽  
Grigore Baciut ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Retrospective Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Timing Of Surgery ◽  
Surgical Correction ◽  
County Hospital ◽  
Occurrence Rate ◽  
Surgical Corrections ◽  
North Western

Cleft lip and palate is the most frequent birth anomaly, with increasing reported rates of complications, such as palate fistulae. Current studies concerning the occurrence rate of cleft lip and palate (CLP) report 2 to 10 cases in 10,000 births. The purpose of this study was to investigate the existence of factors that could predict the occurrence of fistulae after cleft lip and palate surgery. A retrospective study was performed by collecting and analyzing data from all patients who were operated for cleft lip and/or palate in the Maxillo-Facial Department of the Emergency Clinical County Hospital of Cluj-Napoca, Romania, between 2010 and 2020. We investigated the existing evidence for possible links between the number of fistulae observed after the primary palatoplasty and the age at which the primary palatoplasty was performed, the sex of the patient, the type of cleft, the timing of the surgical corrections, and the presence of comorbidities. A total of 137 cases were included for analysis. A significant link between the number of fistulae and the type of cleft was found (with fistulae occurring more frequently after the surgical correction of CLP—p < 0.001). No evidence was found for the existence of significant links between the number of fistulae and the patient’s sex, the timing of surgery, or the presence of comorbidities. This study concluded that the incidence of palatal fistulae appears to be influenced by the type of cleft (CLP), but not by the sex of the patient, the timing of surgery, or the presence of comorbidities.

Prospective evaluation of sentinel node navigation surgery in Japanese patients with low-risk endometrial cancer—safety and occurrence of lymphedema

2021 ◽  
Author(s):  
Hitoshi Niikura ◽  
Asami Toki ◽  
Tomoyuki Nagai ◽  
Satoshi Okamoto ◽  
Shogo Shigeta ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Metastasis ◽  
Lower Extremity ◽  
Lymph Node Biopsy ◽  
Occurrence Rate ◽  
Node Metastasis ◽  
Node Biopsy

Abstract Objective The present study aimed to clarify the occurrence rate of lymphedema and prognosis in patients with endometrial cancer according to sentinel lymph node biopsy alone with intraoperative histopathological examination. Methods The study included 45 consecutive patients with endometrial cancer treated at Tohoku University Hospital between October 2014 and August 2017. All patients had endometrial carcinoma with endometrioid histology Grade 1 or Grade 2 confirmed by biopsy and stage I on magnetic resonance imaging and/or computed tomography at their preoperative evaluation. Sentinel lymph node detection was performed by radioisotope and dye. Patients who were diagnosed intraoperatively as negative for sentinel lymph node metastasis did not undergo further systematic pelvic lymphadenectomy. The occurrence rate of lymphedema and prognosis was evaluated. Results Bilateral sentinel lymph nodes were detected in 44 of 45 patients (97%). Forty-three patients underwent sentinel lymph node biopsy alone, and only two patients underwent systematic lymphadenectomy. Sentinel lymph node metastases were detected in one patient intraoperatively and two patients postoperatively as ITCs. No patients experienced recurrence. New symptomatic lower-extremity lymphedema was identified in one of 43 patients (2.3%) who underwent sentinel lymph node biopsy alone. Conclusion Sentinel lymph node biopsy alone with intraoperative histopathological diagnosis appears to be a safe and effective strategy to detect lymph node metastasis and to reduce the number of patients with lower-extremity lymphedema among patients with endometrial cancer.

scholarly journals Sarcocystis species in bovine carcasses from a Belgian abattoir: a cross-sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hang Zeng ◽  
Inge Van Damme ◽  
Teresia Wanjiru Kabi ◽  
Barbara Šoba ◽  
Sarah Gabriël
Keyword(s):  
Safety Issue ◽  
Cross Sectional Study ◽  
Occurrence Rate ◽  
Sarcocystis Species ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Prevalent Species ◽  
Potential Food ◽  
Effect Of Age

Abstract Background Sarcocystis species are obligatorily heteroxenous parasites, of which some are zoonotic, representing a public health and economic impact. This study investigated the occurrence of Sarcocystis spp. in cattle sampled from a Belgian slaughterhouse. Methods A total of 200 carcasses were included in the study, sampled during 10 sampling days. The sedimentation method was applied to isolate the sarcocysts from both heart and diaphragm muscles collected from each carcass. Multiplex PCR, PCR–RFLP as well as cox1 gene sequencing techniques were applied serially on collected sarcocysts for species identification. Results Sarcocystis spp. were detected in 64% (128/200; 95% CI 57–71%) of the sampled carcasses. Female dairy cattle presented the highest Sarcocystis occurrence rate (91%) as well as the highest Sarcocystis species diversity compared to female beef and male beef. Sarcocystis spp. were detected more often in the heart muscles than in the diaphragm among female beef (p < 0.001) and dairy carcasses (p = 0.001), while in male carcasses no significant difference was observed (p = 0.763). The effect of age was not significant in male carcasses (p = 0.872), while the odds of finding sarcocysts significantly increased with age (p = 0.003) within both types of female carcasses. S. cruzi was the most prevalent species and was found in 56.5% (113/200) of the carcasses, followed by S. hominis (21.0%, 42/200), S. bovifelis (12.5%, 25/200), S. bovini (2.0%, 4/200), S. hirsuta (1.5%, 3/200) and S. heydorni (0.5%, 1/200). Six different species were detected in the diaphragm, while only two species were recovered from the heart. S. cruzi was the most prevalent species in heart, while in the diaphragm, this was S. hominis. Conclusions The detection of S. hominis in 21% of the sampled carcasses presents a potential food safety issue, and further research is warranted into controlling this infection. Graphic Abstract

scholarly journals The correlation between maternal age, parity, cardiac diastolic function and occurrence rate of pre-eclampsia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dan Zhu ◽  
Weiyu Chen ◽  
Yuchen Pan ◽  
Tingcui Li ◽  
Ming Cui ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Diastolic Function ◽  
Maternal Age ◽  
Left Ventricular ◽  
Occurrence Rate ◽  
Left Ventricular Ejection ◽  
Second Trimester ◽  
Ventricular Ejection Fraction ◽  
Primiparous Women ◽  
Effect Of Age

AbstractTo evaluate the effect of age and parity on maternal cardiac diastolic function in second trimester among pregnant women with normal left ventricular ejection fraction. To analyze the correlation between impaired diastolic function and pre-eclampsia. It had been suggested that maternal cardiac adaptations during pregnancy differed between nulliparous and primiparous women and also varied according to age. Impaired cardiac function may precede pre-eclampsia. Therefore, we examined the effects of parity and age on cardiac diastolic function during pregnancy and whether impaired diastolic function during the second trimester correlates with pre-eclampsia. Women with singleton pregnancies at 13 + 0 to 27 + 6 weeks’ gestation and left ventricular ejection fraction (LVEF) ≥ 50% were retrospectively identified. Diastolic function parameters were assessed using transthoracic echocardiography. Pre-eclampsia was identified from medical records. The effect of age and parity on maternal cardiac diastolic function as well as the correlation between impaired diastolic function and occurrence rate of pre-eclampsia were examined. 376 pregnant women were included (median age: 30 years; median gestational age: 14 weeks; 171 primiparous women). LVEF was 66%. Impaired cardiac diastolic function was seen in 7.8% of pregnant women < 35 years compared with 28.6% of those ≥ 35 years (p = 0.000). ROC curve showed women with maternal age over 32 began to have a higher rate of impaired cardiac diastolic function (AUC = 0.704, p = 0.000, sensitivity = 54.5%, specificity = 75.3%). There was no difference in diastolic function indices between maternal women grouped by parity. Higher maternal age was an independent risk factor of declining Em (p < 0.05). Em < 13 cm/s was significantly associated with pre-eclampsia occurrence (HR 8.56; 95% CI 3.40–21.57) after being adjusted for confounders. Maternal age is an independent risk factor for diastolic function decline. There is no difference in cardiac diastolic function between nulliparous women and primiparous women. Pre-eclampsia occurrence is significantly higher in patients with impaired diastolic function at mid-gestation. The application of risk grading using diastolic function at mid-gestation may improve the survival outcomes of pregnant women.

Sign in / Sign up

Export Citation Format

Share Document