A method of extracting speed-dependent vector correlations from 2 + 1 REMPI ion images

2017 ◽  
Vol 147 (1) ◽  
pp. 013947 ◽  
Author(s):  
Wei Wei ◽  
Colin J. Wallace ◽  
Michael P. Grubb ◽  
Simon W. North
Keyword(s):  
Vector Correlations ◽  
Dependent Vector

scholarly journals Extracting Features from Time-Dependent Vector Fields Using Internal Reference Frames

2014 ◽  
Vol 33 (3) ◽  
pp. 21-30 ◽  
Author(s):  
H. Bhatia ◽  
V. Pascucci ◽  
R. M. Kirby ◽  
P.-T. Bremer
Keyword(s):  
Vector Fields ◽  
Reference Frames ◽  
Time Dependent ◽  
Internal Reference ◽  
Dependent Vector

scholarly journals Host Cell DNA Repair Pathways in Adeno-Associated Viral Genome Processing

2006 ◽  
Vol 80 (21) ◽  
pp. 10346-10356 ◽  
Author(s):  
Vivian W. Choi ◽  
Douglas M. McCarty ◽  
R. Jude Samulski
Keyword(s):  
Dna Repair ◽  
Dna Recombination ◽  
Recq Helicase ◽  
Cellular Mechanisms ◽  
Adeno Associated Virus ◽  
Mrn Complex ◽  
Dependent Vector ◽  
Cellular Dna ◽  
Dna Maintenance

ABSTRACT Recentstudies have shown that wild-type and recombinant adeno-associated virus (AAV and rAAV) genomes persist in human tissue predominantly as double-stranded (ds) circular episomes derived from input linear single-stranded virion DNA. Using self-complementary recombinant AAV (scAAV) vectors, we generated intermediates that directly transition to ds circular episomes. The scAAV genome ends are palindromic hairpin-structured terminal repeats, resembling a double-stranded break repair intermediate. Utilizing this substrate, we found cellular DNA recombination and repair factors to be essential for generating circular episomal products. To identify the specific cellular proteins involved, the scAAV circularization-dependent vector was used as a reporter in 19 mammalian DNA repair-deficient cell lines. The results show that RecQ helicase family members (BLM and WRN), Mre11 and NBS1 of the Mre11-Rad50-Nbs1 (MRN) complex, and ATM are required for efficient scAAV genome circularization. We further demonstrated that the scAAV genome requires ATM and DNA-PKCS, but not NBS1, to efficiently convert to a circular form in nondividing cells in vivo using transgenic mice. These studies identify specific pathways involved for further elucidating viral and cellular mechanisms of DNA maintenance important to the viral life cycle and vector utilizations.

Dependent vector types for data structuring in multirate Faust

2011 ◽  
Vol 37 (3) ◽  
pp. 113-131 ◽  
Author(s):  
Pierre Jouvelot ◽  
Yann Orlarey
Keyword(s):  
Dependent Vector ◽  
Data Structuring

STRATIFIED TRANSVERSALITY VIA TIME-DEPENDENT VECTOR FIELDS

2005 ◽  
Vol 71 (02) ◽  
pp. 516-530
Author(s):  
C. MUROLO ◽  
A. A. DU PLESSIS ◽  
D. J. A. TROTMAN
Keyword(s):  
Vector Fields ◽  
Time Dependent ◽  
Dependent Vector
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