The evaluation of serum total sialic acid and lipid-bound sialic acid levels in chronically exposed rats to 7,12-dimethylbenz(a)anthracene and fluoride

2017 ◽  
Author(s):  
Gokhan Oto ◽  
Suat Ekin ◽  
Hasan Uyar ◽  
Hulya Ozdemir ◽  
Damla Yıldız ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Total Sialic Acid

Salivary Total Sialic Acid Levels Increase in Breast Cancer Patients: A Preliminary Study

2011 ◽  
Vol 7 (5) ◽  
pp. 443-447 ◽  
Author(s):  
Leyla Koc Ozturk ◽  
Ebru Emekli-Alturfan ◽  
Emel Kasikci ◽  
Gokhan Demir ◽  
Aysen Yarat
Keyword(s):  
Breast Cancer ◽  
Sialic Acid ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Total Sialic Acid ◽  
Preliminary Study

Studies on the к-casein complex: II. The isolation of a sialic acid-containing fraction by disrupting the complex at low pH in the presence of sodium chloride

1965 ◽  
Vol 32 (1) ◽  
pp. 57-63 ◽  
Author(s):  
R. Beeby
Keyword(s):  
Sialic Acid ◽  
Sodium Chloride ◽  
Deae Cellulose ◽  
Low Ph ◽  
The Other ◽  
Trichloracetic Acid ◽  
Complex Ii ◽  
Total Sialic Acid

SummaryWhen crude к-casein was precipitated at pH 3 in the presence of 0·4m-NaCl the supernatant contained up to 80% of the total sialic acid but no detectable cystine or cysteine. Two fractions were obtained from this supernatant by chromatography on DEAE cellulose; one containing 4–6% sialic acid and the other only onetenth of this amount.Most of the sialic acid of the sialic acid-rich fraction was soluble in 12% trichloracetic acid following treatment with rennin. It is suggested that the glycopeptide released by the action of the enzyme on casein originates from this fraction.

scholarly journals Serum Total Sialic Acid and Highly Sensitive C-reactive Protein: Prognostic Markers for the Diabetic Nephropathy

2016 ◽  
Vol 8 (01) ◽  
pp. 025-029 ◽  
Author(s):  
Vandana Varma ◽  
Meena Varma ◽  
Amit Varma ◽  
Ravindra Kumar ◽  
Anuradha Bharosay ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Sialic Acid ◽  
Multinomial Logistic Regression ◽  
C Reactive Protein ◽  
Diabetes Mellitus Group ◽  
Reactive Protein ◽  
Total Sialic Acid ◽  
Highly Sensitive ◽  
Hs Crp

ABSTRACT Background: This study was undertaken to evaluate and establish the role of total sialic acid (TSA) and highly sensitive C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) and its correlation with complications such as diabetic nephropathy. Materials and Methods: One hundred fifty-seven patients with T2DM with nephropathy (DN) and 162 patients of T2DM without nephropathy (DM) along with 165 unrelated age and sex-matched healthy controls were included in the study. Serum glucose (fasting and postprandial) levels, renal profile, and lipid profile were done as per standard protocol. Serum TSA test levels and hs-CRP level were evaluated using thiobarbituric acid assay and immunoturbidimetric method respectively. Results: We observed a higher concentration of serum TSA (82.67 ± 6.63 mg/dl) and hs-CRP (3.2 ± 1.44 mg/L) in diabetic nephropathy than the diabetes mellitus group (73.83 ± 6.90 mg/dl and 2.07 ± 1.32 mg/L, respectively). Both TSA and hs-CRP levels were found significantly correlated with fasting and postprandial blood sugar, hemoglobin A1c, and urine microalbumin levels in both DM and DN groups. Multinomial logistic regression analysis showed that both TSA and hs-CRP was independently associated with diabetic nephropathy. Conclusion: High serum TSA and hs-CRP levels may increase the microangiopathic (diabetic nephropathy) complications of T2DM.

Quantification of free and total sialic acid excretion by LC–MS/MS

2007 ◽  
Vol 848 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Maria van der Ham ◽  
Berthil H.C.M.T. Prinsen ◽  
Jan G.M. Huijmans ◽  
Nicolaas G.G.M. Abeling ◽  
Bert Dorland ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Acid Excretion ◽  
Total Sialic Acid

Platelet sialic acid and platelet survival after aggregation by ADP

Blood ◽  
1980 ◽  
Vol 56 (5) ◽  
pp. 876-880
Author(s):  
MA Packham ◽  
MA Guccione ◽  
RL Kinlough-Rathbone ◽  
JF Mustard
Keyword(s):  
Sialic Acid ◽  
Human Platelets ◽  
Platelet Surface ◽  
Release Reaction ◽  
Dense Granules ◽  
Total Sialic Acid ◽  
Platelet Survival ◽  
Rabbit Platelets ◽  
Induced Aggregation

Some investigators have reported recently that platelet surface sialic acid is decreased during ADP-induced aggregation, whereas others have reported an increase. Since removal of sialic acid from the platelet surface shortens platelet survival, we have determined the survival of platelets that have been aggregatad by ADP. We have also measured the amount of sialic acid in the suspending fluid of platelets after ADP- induced aggregation. ADP-induced aggregation did not cause the loss of sialic acid from rabbit platelets (which do not undergo a release reaction in response to ADP) nor from washed human platelets in a medium containing physiologic concentrations of calcium in which granule contents are not released. In a medium without added calcium, ADP caused the release of 14C-serotonin (42.5% +/- 3%) from human platelets, but less than 4% of the sialic-acid-containing material was released. It seems likely that little of the releasable sialic acid of platelets is in the dense granules or the alpha-granules. Thrombin (5 U/ml) released 90.0% +/- 3.4% of the serotonin from human platelets but only 20.6% +/- 7.4% of the total sialic-acid-containing material. Neuraminidase removed 42.3% of the total sialic acid, presumably from the platelet surface. Rabbit platelets that had been aggregated by ADP and deaggregated survived normally when returned to the circulation. This observation also provides evidence that they had not lost membrane sialic acid during aggregation and deaggregation.

Total sialic acid, lipid-bound sialic acid, ceruloplasmin, and fibrinogen levels in malign and benign pleural diseases

Lung Cancer ◽  
1994 ◽  
Vol 11 ◽  
pp. 78
Author(s):  
Numan Numanoǧlu ◽  
Turan Karayilanoǧlu ◽  
Uǧur Gönüllü ◽  
Özlem Özdemir ◽  
Yildir Atakurt ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Pleural Diseases ◽  
Total Sialic Acid
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