Enhanced biocompatibility of multi-walled carbon nanotubes by surface modification: Future perspectives for drug delivery system

2017 ◽  
Author(s):  
C. M. S. Anandhi ◽  
R. Mohamed Asath ◽  
T. Mathavan ◽  
A. Milton Franklin Benial
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Surface Modification ◽  
Drug Delivery System ◽  
Delivery System ◽  
Future Perspectives ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Single-walled and multi-walled carbon nanotubes based drug delivery system: Cancer therapy: A review

2015 ◽  
Vol 52 (3) ◽  
pp. 262 ◽  
Author(s):  
B Dineshkumar ◽  
K Krishnakumar ◽  
AR Bhatt ◽  
D Paul ◽  
J Cherian ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

2021 ◽  
Vol 17 (9) ◽  
pp. 1711-1725
Author(s):  
Ru Zhang ◽  
Shang Luo ◽  
Lin-Kun Hao ◽  
Yun-Ying Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Rabbit Model ◽  
Order Kinetic ◽  
Thrombolytic Drug ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

The Use of Multi-Walled Carbon Nanotubes as Possible Carrier in Drug Delivery System for Aspirin

2009 ◽  
Author(s):  
Alias Mohd. Yusof ◽  
Nor Aziah Buang ◽  
Lee Sze Yean ◽  
Mohd. Lokman Ibrahim ◽  
Mohamad Rusop ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Invitro study of multiwall carbon nanotubes (MWCNTs) with adsorbed mitoxantrone (MTO) as a drug delivery system to treat breast cancer

RSC Advances ◽  
2014 ◽  
Vol 4 (36) ◽  
pp. 18683-18693 ◽  
Author(s):  
Giulia Risi ◽  
Nora Bloise ◽  
Daniele Merli ◽  
Antonia Icaro-Cornaglia ◽  
Antonella Profumo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiwall Carbon Nanotubes ◽  
System P ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Treat Breast Cancer

Mitoxantrone 600 dpi in TIF format)??>(MTO) is a well-known anticancer drug. In order to improve its therapeutic effect, multi-walled carbon nanotubes (MWCNTs) were studied in vitro as a drug delivery system.

scholarly journals Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System

2013 ◽  
Vol 16 (1) ◽  
pp. 40 ◽  
Author(s):  
Chengqun Chen ◽  
Huijuan Zhang ◽  
Lin Hou ◽  
Jinjin Shi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Single Walled Carbon Nanotubes ◽  
Antitumor Drug ◽  
Mice Model ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Purpose. The aim of this study was to prepare a new neovascularity targeting antitumor drug delivery system mediated by single-walled carbon nanotubes (SWNTs). Methods. In this study, antiangiogenesis agent 2-methoxyestradiol was loaded by SWNTs via π~π accumulation. The SWNTs were then linked with NGR (Asn-Gly-Arg) peptide, which could target tumor angiogenesis. This drug delivery system was characterized by transmission electron microscope, scanning electron microscopy, and atomic force microscope analysis. The suppression efficacy of tumor growth in cultured breast cancer cell line was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The in vivo antitumor activity was evaluated on the Sarcoma (S180) tumor-bearing mice model. Results. The characteristics of this drug delivery system showed that the particle of complex was 190 ± 4.3 nm in size distribution and 23.56 ± 2.03 mV in zeta potential. The inhibition ratio of this SWNTs drug delivery system at 24, 48, and 72 h was about 57.7%, 83.6%, and 88.2%. Compared with normal saline group, the relative tumor volumes in the 2ME, SWNTs-2ME, and NGR-SWNTs-2ME groups were decreased 1 week after administration. Conclusion. This novel neovascularity targeting drug delivery system containing NGR-SWNTs-2ME may be beneficial to improve treatment efficacy and minimize side effects in future cancer therapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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