scholarly journals A cost-effective monitoring technique in particle therapy via uncollimated prompt gamma peak integration

2017 ◽  
Vol 110 (15) ◽  
pp. 154102 ◽  
Author(s):  
J. Krimmer ◽  
G. Angellier ◽  
L. Balleyguier ◽  
D. Dauvergne ◽  
N. Freud ◽  
...  
Keyword(s):  
Cost Effective ◽  
Particle Therapy ◽  
Prompt Gamma ◽  
Peak Integration ◽  
Monitoring Technique ◽  
Gamma Peak

scholarly journals Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design

2020 ◽  
Vol 8 ◽  
Author(s):  
L. Bottura ◽  
E. Felcini ◽  
V. Ferrero ◽  
E. Fiorina ◽  
V. Monaco ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Integrated Design ◽  
Cost Effective ◽  
Target Volume ◽  
Particle Therapy ◽  
Treatment Delivery ◽  
Expected Performance ◽  
Beam Delivery ◽  
Technological Improvements ◽  
System Prototype

The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a highly flexible and fast beam delivery, single particle counting capability for fast measurement of beam fluence and position and a precise real time verification of the compliance between the treatment delivery and its prescription. The gantry configuration is discussed, presenting an analysis of the residual magnetic field in the bore and of the feasibility of irradiating a realistic target volume. Moreover, the expected performance of the PET-based range monitor is assessed through Monte Carlo simulations, showing a precision in the reconstruction of the activity distribution from a clinical treatment plan better than the state-of-the-art devices. The feasibility of the proposed design is then discussed through an assessment of the technological improvements required to actually start the construction and commissioning of a system prototype.

scholarly journals PAPRICA: The Pair Production Imaging Chamber—Proof of Principle

2021 ◽  
Vol 9 ◽  
Author(s):  
M. Toppi ◽  
I. Avanzolini ◽  
L. Balconi ◽  
G. Battistoni ◽  
G. Calvi ◽  
...  
Keyword(s):  
Pair Production ◽  
Pediatric Patients ◽  
Tumor Volume ◽  
Organs At Risk ◽  
Particle Therapy ◽  
Adequate Dose ◽  
Monitoring Technique ◽  
Safety Margins ◽  
Beam Range ◽  
Proof Of Principle

In Particle Therapy, safety margins are applied around the tumor to account for the beam range uncertainties and ensure an adequate dose coverage of the tumor volume during the therapy. The reduction of safety margins is in great demand in order to diminish the Particle Therapy side effects especially in the case of treatment of tumors close to Organs at Risk (OAR) and of pediatric patients. To this aim, beam range monitoring techniques are being developed by the scientific community, most of all based on the detection of secondary particles produced by the nuclear interactions of the beam with the patient’s tissue nuclei. In this contribution, a novel beam range monitoring technique is proposed, based on the detection of prompt photons exploiting the pair production mechanism. The proof of principle of the PAir PRoduction Imaging ChAmber (PAPRICA) is studied through the development of a Monte Carlo simulation and the detector performances toward a more realistic scenario are determined.

scholarly journals Characterization of prompt gamma ray emission for in vivo range verification in particle therapy: A simulation study

2019 ◽  
Vol 62 ◽  
pp. 20-32 ◽  
Author(s):  
Melek Zarifi ◽  
Susanna Guatelli ◽  
Yujin Qi ◽  
David Bolst ◽  
Dale Prokopovich ◽  
...  
Keyword(s):  
Simulation Study ◽  
Gamma Ray ◽  
Particle Therapy ◽  
Prompt Gamma ◽  
Gamma Ray Emission ◽  
Range Verification

OHP-041 Metal Hair analysis, a cost-effective monitoring technique to asses high ion level exposure in patients with metal on metal prosthesis

2014 ◽  
Vol 21 (Suppl 1) ◽  
pp. A202.1-A202
Author(s):  
M Rodríguez de Laflor García ◽  
R Ramos Aparicio ◽  
CP Puente Martínez ◽  
D Hernández Vaquero
Keyword(s):  
Hair Analysis ◽  
Cost Effective ◽  
Monitoring Technique ◽  
Metal On Metal

scholarly journals Prompt Gamma based Detection and Discrimination of 2 Neutron Capture Events for NCEPT Dose 3 Quantification

2021 ◽  
Author(s):  
Andrew Chacon ◽  
Marissa Kielly ◽  
Harley Rutherford ◽  
Daniel R. Franklin ◽  
Anita Caracciolo ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Neutron Capture ◽  
False Positives ◽  
Particle Therapy ◽  
In Vivo Dosimetry ◽  
Prompt Gamma ◽  
Depth Range ◽  
Neutron Shielding ◽  
Monte Carlo Simulation Study

Abstract Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of particle therapy by capturing thermal neutrons produced by beam-target nuclear interactions in and around the treatment site, using tumour-specific 10B or 157Gd-based neutron capture agents. Neutron captures release high-LET secondary particles together with prompt gamma photons with energies of 478 keV (10B) or 7.94 MeV (157Gd). A key requirement for NCEPT’s translation is the development of in vivo dosimetry techniques which can measure both the direct ion dose and the dose due to neutron capture. In this work, we report signatures which can be used to discriminate between photons resulting from neutron capture and those originating from other processes. A Geant4 Monte Carlo simulation study into timing and energy thresholds for discrimination of prompt gamma photons resulting from thermal neutron capture during NCEPT was conducted. Three simulated 300×300×300 mm3 cubic PMMA targets were irradiated by 4He or 12C ion beams with a spread out Bragg peak (SOBP) depth range of 60 mm; one target is homogeneous while the others include 10×10×10 mm3 neutron capture inserts (NCIs) of pure 10B or 157Gd located at the distal edge of the SOBP. The arrival times of photons and neutrons entering a simulated 50×50×50 mm3 ideal detector were recorded. The majority of photons resulting from neutron capture were found to arrive at the detector at least 60 ns later than photons created by other processes. A range of candidate detector and thermal neutron shielding materials were simulated, and detections meeting the proposed acceptance criteria (i.e. falling within the target energy window and arriving 60 ns post beam-off) were classified as true or false positives, depending on their origin. The ratio of true / false positives (RTF) was calculated; for targets with 10B and 157Gd NCIs, the detector materials which resulted in the highest RTF were cadmium-shielded CdTe and boron-shielded LSO, respectively. The optimal irradiation period for both carbon and helium ions was 1 µs for the 10B NCI and 1 ms for the 157Gd NCI.

90: Comparison of Scintillation Detectors based on BGO and LSO for Prompt Gamma Imaging in Particle Therapy

2014 ◽  
Vol 110 ◽  
pp. S44
Author(s):  
F. Hueso-González ◽  
D. Bemmerer ◽  
M. Berthel ◽  
A.K. Biegun ◽  
J.v. Borany ◽  
...  
Keyword(s):  
Particle Therapy ◽  
Prompt Gamma ◽  
Scintillation Detectors ◽  
Gamma Imaging ◽  
Prompt Gamma Imaging

Oil Analysis Cost-Effective Compressor Condition Computer Monitoring Technique

2014 ◽  
Vol 962-965 ◽  
pp. 2827-2830
Author(s):  
Zhen Bao Sun
Keyword(s):  
Trend Analysis ◽  
Condition Monitoring ◽  
Analytical Methods ◽  
Cost Effective ◽  
Oil Analysis ◽  
Computer Monitoring ◽  
Monitoring Technique

This paper describes the development of the use of lubricant analytical programmes and trend analysis to optimise oil change intervals and to predict compressor failure. The various analytical methods are covered, as are the most frequently occurring lubricant applications where such condition monitoring programmes are most appropriate.

103 TECHNIQUES FOR IMAGE BASED IN-VIVO DOSIMETRY: FROM PARTICLE THERAPY PET TO IN-BEAM PROMPT GAMMA IMAGING

2012 ◽  
Vol 102 ◽  
pp. S40-S41
Author(s):  
F. Fiedler ◽  
U. Dersch ◽  
C. Golnik ◽  
S. Helmbrecht ◽  
T. Kormoll ◽  
...  
Keyword(s):  
Particle Therapy ◽  
In Vivo Dosimetry ◽  
Prompt Gamma ◽  
Gamma Imaging ◽  
Prompt Gamma Imaging
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