Linac-based total body irradiation (TBI) with volumetric modulated arc therapy (VMAT)

2017 ◽  
Author(s):  
B. Tas ◽  
I. F. Durmus ◽  
A. Okumus ◽  
O. E. Uzel
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body

Total-body irradiation using linac-based volumetric modulated arc therapy: Its clinical accuracy, feasibility and reliability

2018 ◽  
Vol 129 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Bora Tas ◽  
Ismail Faruk Durmus ◽  
Ayse Okumus ◽  
Omer Erol Uzel ◽  
Muge Gokce ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Clinical Accuracy ◽  
Total Body

Volumetric Modulated Arc Therapy Based Total Body Irradiation – Five Year Clinical Experience

2020 ◽  
Vol 108 (3) ◽  
pp. e753
Author(s):  
E.R. Zhang-Velten ◽  
D.D.M. Parsons ◽  
J. Tan ◽  
M. Joo ◽  
R.R. Reynolds ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body

EP-1546: Dose planning of a total body irradiation with Volumetric Modulated Arc Therapy (VMAT)

2014 ◽  
Vol 111 ◽  
pp. S182
Author(s):  
A. Springer ◽  
E. Winkler ◽  
E. Putz ◽  
A. Altenburger ◽  
R. Gruber ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Dose Planning ◽  
Arc Therapy ◽  
Total Body

scholarly journals Feasibility study of volumetric modulated arc therapy with Halcyon™ linac for total body irradiation

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Takuya Uehara ◽  
Hajime Monzen ◽  
Mikoto Tamura ◽  
Masahiro Inada ◽  
Masakazu Otsuka ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Organs At Risk ◽  
Volumetric Modulated Arc Therapy ◽  
Dose Calculation ◽  
Target Volume ◽  
The Body ◽  
Whole Body ◽  
Data Set ◽  
Arc Therapy ◽  
Total Body

Abstract Background The use of total body irradiation (TBI) with linac-based volumetric modulated arc therapy (VMAT) has been steadily increasing. Helical tomotherapy has been applied in TBI and total marrow irradiation to reduce the dose to critical organs, especially the lungs. However, the methodology of TBI with Halcyon™ linac remains unclear. This study aimed to evaluate whether VMAT with Halcyon™ linac can be clinically used for TBI. Methods VMAT planning with Halcyon™ linac was conducted using a whole-body computed tomography data set. The planning target volume (PTV) included the body cropped 3 mm from the source. A dose of 12 Gy in six fractions was prescribed for 50% of the PTV. The organs at risk (OARs) included the lens, lungs, kidneys, and testes. Results The PTV D98%, D95%, D50%, and D2% were 8.9 (74.2%), 10.1 (84.2%), 12.6 (105%), and 14.2 Gy (118%), respectively. The homogeneity index was 0.42. For OARs, the Dmean of the lungs, kidneys, lens, and testes were 9.6, 8.5, 8.9, and 4.4 Gy, respectively. The V12Gy of the lungs and kidneys were 4.5% and 0%, respectively. The Dmax of the testes was 5.8 Gy. Contouring took 1–2 h. Dose calculation and optimization was performed for 3–4 h. Quality assurance (QA) took 2–3 h. The treatment duration was 23 min. Conclusions A planning study of TBI with Halcyon™ to set up VMAT-TBI, dosimetric evaluation, and pretreatment QA, was established.

EP-1049: The introduction of volumetric modulated arc therapy to total body irradiation (TBI) ñ first experiences

2014 ◽  
Vol 111 ◽  
pp. S2
Author(s):  
C. Track ◽  
J. Hammer ◽  
A. Springer ◽  
E. Winkler ◽  
A. Weltermann ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body

scholarly journals Optimized Conformal Total Body Irradiation Among Recipients of TCRαβ/CD19-Depleted Grafts in Pediatric Patients With Hematologic Malignancies: Single-Center Experience

2021 ◽  
Vol 11 ◽  
Author(s):  
Daria Kobyzeva ◽  
Larisa Shelikhova ◽  
Anna Loginova ◽  
Francheska Kanestri ◽  
Diana Tovmasyan ◽  
...  
Keyword(s):  
At Risk ◽  
Radiation Therapy ◽  
Dose Reduction ◽  
Total Body Irradiation ◽  
Pediatric Patients ◽  
Organs At Risk ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body

Total body irradiation (TBI) in combination with chemotherapy is widely used as a conditioning regimen in pediatric and adult hematopoietic stem cell transplantation (HSCT). The combination of TBI with chemotherapy has demonstrated superior survival outcomes in patients with acute lymphoblastic and myeloid leukemia when compared with conditioning regimens based only on chemotherapy. The clinical application of intensity-modulated radiation therapy (IMRT)-based methods (volumetric modulated arc therapy (VMAT) and TomoTherapy) seems to be promising and has been actively used worldwide. The optimized conformal total body irradiation (OC-TBI) method described in this study provides selected dose reduction for organs at risk with respect to the most significant toxicity (lungs, kidneys, lenses). This study included 220 pediatric patients who received OC-TBI with subsequent chemotherapy and allogenic HSCT with TCRαβ/CD19 depletion. A group of 151 patients received OC-TBI using TomoTherapy, and 40 patients received OC-TBI using the Elekta Synergy™ linac with an Agility-MLC (Elekta, Crawley, UK) using volumetric modulated arc therapy (VMAT). Twenty-nine patients received OC-TBI with supplemental simultaneous boost to bone marrow—(SIB to BM) up to 15 Gy: 28 patients (pts)—TomoTherapy; one patient—VMAT. The follow-up duration ranged from 0.3 to 6.4 years (median follow-up, 2.8 years). Overall survival (OS) for all the patients was 63% (95% CI: 56–70), and event-free survival (EFS) was 58% (95% CI: 51–65). The cumulative incidence of transplant-related mortality (TRM) was 10.7% (95% CI: 2.2–16) for all patients. The incidence of early TRM (<100 days) was 5.0% (95% CI: 1.5–8.9), and that of late TRM (>100 days) was 5.7 (95% CI: 1.7–10.2). The main causes of death for all the patients were relapse and infection. The concept of OC-TBI using IMRT VMAT and helical treatment delivery on a TomoTherapy treatment unit provides maximum control of the dose distribution in extended targets with simultaneous dose reduction for organs at risk. This method demonstrated a low incidence of severe side effects after radiation therapy and predictable treatment effectiveness. Our initial experience demonstrates that OC-TBI appears to be a promising technique for the treatment of pediatric patients.

SU-E-T-592: Investigation of Volumetric Modulated Arc Therapy for Total Body Irradiation with Lung Blocks

2013 ◽  
Vol 40 (6Part20) ◽  
pp. 341-341
Author(s):  
H Wang ◽  
S Tung ◽  
C Wang ◽  
A Mahajan ◽  
B Dabaja ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body

SU-E-T-812: Volumetric Modulated Arc Therapy-Total Body Irradiation (VMAT-TBI) V.s. Conventional Extended SSD-TBI (cTBI): A Dosimetric Comparisom

2015 ◽  
Vol 42 (6Part25) ◽  
pp. 3524-3524
Author(s):  
L Ouyang ◽  
M Folkerts ◽  
H Lee ◽  
E Ramirez ◽  
R Timmerman ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Volumetric Modulated Arc Therapy ◽  
Arc Therapy ◽  
Total Body
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