Interplay between alkyl chain asymmetry and cholesterol addition in the rigid ion pair amphiphile bilayer systems

2017 ◽  
Vol 146 (3) ◽  
pp. 035102 ◽  
Author(s):  
Fong-yin Huang ◽  
Chi-cheng Chiu
Keyword(s):  
Alkyl Chain ◽  
Ion Pair ◽  
Ion Pair Amphiphile

scholarly journals Effects of Cholesterol on Water Permittivity of Biomimetic Ion Pair Amphiphile Bilayers: Interplay between Membrane Bending and Molecular Packing

2019 ◽  
Vol 20 (13) ◽  
pp. 3252
Author(s):  
Wu-jhao Tien ◽  
Kun-you Chen ◽  
Fong-yin Huang ◽  
Chi-cheng Chiu
Keyword(s):  
Alkyl Chain ◽  
Synergistic Effects ◽  
Deformation Energy ◽  
Ion Pair ◽  
Molecular Packing ◽  
Energy Penalty ◽  
Membrane Bending ◽  
Dynamics Simulations ◽  
Chain Ordering ◽  
Ion Pair Amphiphile

Ion pair amphiphile (IPA), a molecular complex composed of a pair of cationic and anionic amphiphiles, is an inexpensive phospholipid substitute to fabricate vesicles with various pharmaceutical applications. Modulating the physicochemical and permeation properties of IPA vesicles are important for carrier designs. Here, we applied molecular dynamics simulations to examine the cholesterol effects on the structures, mechanics, and water permittivity of hexadecyltrimethylammonium-dodecylsulfate (HTMA-DS) and dodecyltrimethylammonium- hexadecylsulfate (DTMA-HS) IPA bilayers. Structural and mechanical analyses indicate that both IPA systems are in gel phase at 298 K. Adding cholesterol induces alkyl chain ordering around the rigid sterol ring and increases the cavity density within the hydrophilic region of both IPA bilayers. Furthermore, the enhanced alkyl chain ordering and the membrane deformation energy induced by cholesterol increase the permeation free energy penalty. In contrast, cholesterol has minor effects on the water local diffusivities within IPA membranes. Overall, the cholesterol reduces the water permittivity of rigid IPA membranes due to the synergistic effects of increased alkyl chain ordering and enhanced membrane mechanical modulus. The results provide molecular insights into the effects of molecular packing and mechanical deformations on the water permittivity of biomimetic IPA membranes, which is critical for designing IPA vesicular carriers.

Molecular Dynamics Study of Catanionic Bilayers Composed of Ion Pair Amphiphile with Double-Tailed Cationic Surfactant

Langmuir ◽  
2012 ◽  
Vol 28 (21) ◽  
pp. 8156-8164 ◽  
Author(s):  
An-Tsung Kuo ◽  
Chien-Hsiang Chang ◽  
Wataru Shinoda
Keyword(s):  
Molecular Dynamics ◽  
Cationic Surfactant ◽  
Ion Pair ◽  
Ion Pair Amphiphile

scholarly journals Effects of Ethanol and Cholesterol on Thermotropic Phase Behavior of Ion-Pair Amphiphile Bilayers

2017 ◽  
Vol 67 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Chih-Fang Wen ◽  
Yu-Ling Hsieh ◽  
Chun-Wei Wang ◽  
Tzung-Ying Yang ◽  
Chien-Hsiang Chang ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Ion Pair ◽  
Ion Pair Amphiphile

Fabrication of positively charged catanionic vesicles from ion pair amphiphile with double-chained cationic surfactant

2013 ◽  
Vol 292 (3) ◽  
pp. 589-597 ◽  
Author(s):  
Chih-Jung Wu ◽  
An-Tsung Kuo ◽  
Chen-Hsuan Lee ◽  
Yu-Min Yang ◽  
Chien-Hsiang Chang
Keyword(s):  
Cationic Surfactant ◽  
Ion Pair ◽  
Catanionic Vesicles ◽  
Positively Charged ◽  
Ion Pair Amphiphile

Polymerizable ion-pair amphiphile that has a polymerizable group at cationic ammonium chain

2004 ◽  
Vol 39 (4) ◽  
pp. 165-170 ◽  
Author(s):  
Myung-Hoon Chung ◽  
Jung-Hwan Park ◽  
Byoung Chul Chun ◽  
Yong-Chan Chung
Keyword(s):  
Ion Pair ◽  
Ion Pair Amphiphile ◽  
Polymerizable Group
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