High temperature gradient micro-sensor for wall shear stress and flow direction measurements

2016 ◽  
Vol 109 (24) ◽  
pp. 241905 ◽  
Author(s):  
C. Ghouila-Houri ◽  
J. Claudel ◽  
J.-C. Gerbedoen ◽  
Q. Gallas ◽  
E. Garnier ◽  
...  
2017 ◽  
Vol 266 ◽  
pp. 232-241 ◽  
Author(s):  
Cécile Ghouila-Houri ◽  
Quentin Gallas ◽  
Eric Garnier ◽  
Alain Merlen ◽  
Romain Viard ◽  
...  

Author(s):  
Karol Calò ◽  
Giuseppe De Nisco ◽  
Diego Gallo ◽  
Claudio Chiastra ◽  
Ayla Hoogendoorn ◽  
...  

Atherosclerosis at the early stage in coronary arteries has been associated with low cycle-average wall shear stress magnitude. However, parallel to the identification of an established active role for low wall shear stress in the onset/progression of the atherosclerotic disease, a weak association between lesions localization and low/oscillatory wall shear stress has been observed. In the attempt to fully identify the wall shear stress phenotype triggering early atherosclerosis in coronary arteries, this exploratory study aims at enriching the characterization of wall shear stress emerging features combining correlation-based analysis and complex networks theory with computational hemodynamics. The final goal is the characterization of the spatiotemporal and topological heterogeneity of wall shear stress waveforms along the cardiac cycle. In detail, here time-histories of wall shear stress magnitude and wall shear stress projection along the main flow direction and orthogonal to it (a measure of wall shear stress multidirectionality) are analyzed in a representative dataset of 10 left anterior descending pig coronary artery computational hemodynamics models. Among the main findings, we report that the proposed analysis quantitatively demonstrates that the model-specific inlet flow-rate shapes wall shear stress time-histories. Moreover, it emerges that a combined effect of low wall shear stress magnitude and of the shape of the wall shear stress–based descriptors time-histories could trigger atherosclerosis at its earliest stage. The findings of this work suggest for new experiments to provide a clearer determination of the wall shear stress phenotype which is at the basis of the so-called arterial hemodynamic risk hypothesis in coronary arteries.


Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2682 ◽  
Author(s):  
Guang-Hui Ding ◽  
Bing-He Ma ◽  
Jin-Jun Deng ◽  
Wei-Zheng Yuan ◽  
Kang Liu

A micro-floating element wall shear stress sensor with backside connections has been developed for accurate measurements of wall shear stress under the turbulent boundary layer. The micro-sensor was designed and fabricated on a 10.16 cm SOI (Silicon on Insulator) wafer by MEMS (Micro-Electro-Mechanical System) processing technology. Then, it was calibrated by a wind tunnel setup over a range of 0 Pa to 65 Pa. The measurements of wall shear stress on a smooth plate were carried out in a 0.6 m × 0.6 m transonic wind tunnel. Flow speed ranges from 0.4 Ma to 0.8 Ma, with a corresponding Reynold number of 1.05 × 106~1.55 × 106 at the micro-sensor location. Wall shear stress measured by the micro-sensor has a range of about 34 Pa to 93 Pa, which is consistent with theoretical values. For comparisons, a Preston tube was also used to measure wall shear stress at the same time. The results show that wall shear stress obtained by three methods (the micro-sensor, a Preston tube, and theoretical results) are well agreed with each other.


Author(s):  
Leonie Rouleau ◽  
Monica Farcas ◽  
Jean-Claude Tardif ◽  
Rosaire Mongrain ◽  
Richard Leask

Endothelial cell (EC) dysfunction has been linked to atherosclerosis through their response to hemodynamic forces. Flow in stenotic vessels creates complex spatial gradients in wall shear stress. In vitro studies examining the effect of shear stress on endothelial cells have used unrealistic and simplified models, which cannot reproduce physiological conditions. The objective of this study was to expose endothelial cells to the complex shear shear pattern created by an asymmetric stenosis. Endothelial cells were grown and exposed for different times to physiological steady flow in straight dynamic controls and in idealized asymmetric stenosis models. Cells subjected to 1D flow aligned with flow direction and had a spindle-like shape when compared to static controls. Endothelial cell morphology was noticeable different in the regions with a spatial gradient in wall shear stress, being more randomly oriented and of cobblestone shape. This occurred despite the presence of an increased magnitude in shear stress. No other study to date has described this morphology in the presence of a positive wall shear stress gradient or gradient of significant shear magnitude. This technique provides a more realistic model to study endothelial cell response to spatial and temporal shear stress gradients that are present in vivo and is an important advancement towards a better understanding of the mechanisms involved in coronary artery disease.


2017 ◽  
Vol 111 (11) ◽  
pp. 113502 ◽  
Author(s):  
C. Ghouila-Houri ◽  
A. Talbi ◽  
R. Viard ◽  
M. Moutaouekkil ◽  
O. Elmazria ◽  
...  

2020 ◽  
Vol 88 (2) ◽  
Author(s):  
Yuxi Jia ◽  
Kumaradevan Punithakumar ◽  
Michelle Noga ◽  
Arman Hemmati

Abstract The characteristics of blood flow in an abnormal pediatric aorta with an aortic coarctation and aortic arch narrowing are examined using direct numerical simulations and patient-specific boundary conditions. The blood flow simulations of a normal pediatric aorta are used for comparison to identify unique flow features resulting from the aorta geometrical anomalies. Despite flow similarities compared to the flow in normal aortic arch, the flow velocity decreases with an increase in pressure, wall shear stress, and vorticity around both anomalies. The presence of wall shear stresses in the trailing indentation region and aorta coarctation opposing the primary flow direction suggests that there exist recirculation zones in the aorta. The discrepancy in relative flowrates through the top and bottom of the aorta outlets, and the pressure drop across the coarctation, implies a high blood pressure in the upper body and a low blood pressure in the lower body. We propose using flow manipulators prior to the aortic arch and coarctation to lower the wall shear stress, while making the recirculation regions both smaller and weaker. The flow manipulators form a guide to divert and correct blood flow in critical regions of the aorta with anomalies.


2019 ◽  
Vol 60 (4) ◽  
Author(s):  
Cecile Ghouila-Houri ◽  
Abdelkrim Talbi ◽  
Romain Viard ◽  
Quentin Gallas ◽  
Eric Garnier ◽  
...  

2014 ◽  
Vol 70 (2) ◽  
Author(s):  
H. C. Teoh ◽  
S. O. Lai

Computational fluids dynamics (CFD) modelling has been carried out for a spacer-filled membrane channel using ANSYS FLUENT 14.0. The effect of spacer angles relative to the feed flow direction and different spacer shape combinations on velocity magnitude, wall shear stress, pressure drop and power number were investigated. From the results, spacer angle of 63.565° is the best orientation as it can generate the highest shear stress and reasonably lower power number compared to other spacer angles. Although the combinations of spacer shape did not significantly improve the average wall shear stress, it helped in reducing the pressure drop of the channel. The combination of triangular and circular spacers provided lower Power number, and hence lower energy consumption was required compared to pure triangular spacer. The current results indicated that a combination of triangular and circular spacers can be employed to offer better saving in energy consumption.


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