In vivo visualization method by absolute blood flow velocity based on speckle and fringe pattern using two-beam multipoint laser Doppler velocimetry

2016 ◽  
Vol 120 (8) ◽  
pp. 084701 ◽  
Author(s):  
Tomoaki Kyoden ◽  
Shoji Naruki ◽  
Shunsuke Akiguchi ◽  
Hiroki Ishida ◽  
Tsugunobu Andoh ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Laser Doppler Velocimetry ◽  
Fringe Pattern ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Visualization Method

Blood flow velocity imaging of malignant melanoma by micro multipoint laser Doppler velocimetry

2010 ◽  
Vol 97 (10) ◽  
pp. 103702 ◽  
Author(s):  
H. Ishida ◽  
T. Andoh ◽  
S. Akiguchi ◽  
H. Shirakawa ◽  
D. Kobayashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Malignant Melanoma ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Laser Doppler Velocimetry ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Velocity Imaging

Power spectrum and blood flow velocity images obtained by dual-beam backscatter laser Doppler velocimetry

2014 ◽  
Vol 21 (4) ◽  
pp. 461-467 ◽  
Author(s):  
Hiroki Ishida ◽  
Youichi Yasue ◽  
Tadashi Hachiga ◽  
Tsugunobu Andoh ◽  
Shunsuke Akiguchi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Power Spectrum ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Laser Doppler Velocimetry ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Dual Beam ◽  
Velocity Images

Examining the relationship between blood flow velocity and movement of erythrocytes in a capillary using laser doppler velocimetry

2016 ◽  
Vol 11 (4) ◽  
pp. 451-456 ◽  
Author(s):  
Shunsuke Akiguchi ◽  
Hiroki Ishida ◽  
Yogo Takada ◽  
Tsunenobu Teranishi ◽  
Tsugunobu Andoh ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Laser Doppler Velocimetry ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
The Relationship

Recent advances in self-mixing laser-Doppler velocimetry: use as an in-vivo blood flow meter

2000 ◽  
Author(s):  
Lorenzo Scalise ◽  
Frits F. M. de Mul ◽  
Wiendelt Steenbergen ◽  
Anna L. Petoukhova
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Flow Meter ◽  
Recent Advances

Preclinical Quantification of Prostate Cancer-Associated Vascular Alterations in the Bone Microenvironment in vivo

2020 ◽  
Vol 61 (6) ◽  
pp. 188-200
Author(s):  
Malte Schroeder ◽  
Lennart Viezens ◽  
Jördis Sündermann ◽  
Svenja Hettenhausen ◽  
Gerrit Hauenherm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Blood Flow ◽  
Flow Velocity ◽  
Cell Lines ◽  
Blood Flow Velocity ◽  
Tumour Growth ◽  
Prostate Cancer Cell ◽  
Bone Microenvironment ◽  
Prostate Cancer Cell Lines

Introduction: Prostate cancer has a special predilection to form bone metastases. Despite the known impact of the microvascular network on tumour growth and its dependence on the organ-specific microenvironment, the characteristics of the tumour vasculature in bone remain unknown. Methods: The cell lines LNCaP, DU145, and PC3 were implanted into the femurs of NSG mice to examine the microvascular properties of prostate cancer in bone. Tumour growth and the functional and morphological alterations of the microvasculature were analysed for 21 days in vivo using a transparent bone chamber and fluorescence microscopy. Results: Vascular density was significantly lower in tumour-bearing bone than in non-tumour-bearing bone, with a marked loss of small vessels. Accelerated blood flow velocity led to increased volumetric blood flow per vessel, but overall perfusion was not affected. All of the prostate cancer cell lines had similar vascular patterns, with more pronounced alterations in rapidly growing tumours. Despite minor differences between the prostate cancer cell lines associated with individual growth behaviours, the same overall pattern was observed and showed strong similarity to that of tumours growing in soft tissue. Discussion: The increase in blood flow velocity could be a specific characteristic of prostate cancer or the bone microenvironment.

Laser Doppler velocimetry: a new technique for the measurement of intestinal mucosal blood flow

1984 ◽  
Vol 30 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Andrew D. Feld ◽  
Joseph D. Fondacaro ◽  
G. Allen Holloway ◽  
Eugene D. Jacobson
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Mucosal Blood Flow ◽  
Laser Doppler ◽  
New Technique ◽  
Doppler Velocimetry ◽  
A New Technique

Hybrid blood flow probe for simultaneous H2 clearance and laser-Doppler velocimetry

1987 ◽  
Vol 253 (4) ◽  
pp. G573-G581 ◽  
Author(s):  
G. R. DiResta ◽  
J. W. Kiel ◽  
G. L. Riedel ◽  
P. Kaplan ◽  
A. P. Shepherd
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Regional Blood Flow ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Flow Probe ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Light Guides ◽  
The Relationship

To perform two independent regional blood flow measurements in tissue volumes of similar dimensions, we designed a hybrid blood flow probe capable of measuring regional perfusion by both laser-Doppler velocimetry (LDV) and H2 clearance. The probe consisted of two fiber-optic light guides to conduct light between the surface of tissue of interest and a laser-Doppler blood flowmeter. Also contained within the probe were a platinum 25-microns H2-sensing electrode and a 125-microns H2-generating electrode. The probe can thus be used to measure local perfusion with H2 clearance. The H2 can either be inhaled or can be generated electrochemically at the locus of interest. Evaluation of the probe in the canine gastric mucosa indicated 1) that the relationship between mucosal flow measurements made simultaneously with H2 clearance and LDV was highly significant and linear and 2) that H2 clearance could potentially be used to calibrate the laser-Doppler blood flowmeter in absolute units. The methods of constructing the flow probes are discussed in detail.

Differences in reactive hyperemia between the intestinal mucosa and muscularis

1984 ◽  
Vol 247 (6) ◽  
pp. G617-G622
Author(s):  
A. P. Shepherd ◽  
G. L. Riedel
Keyword(s):  
Blood Flow ◽  
Metabolic Rate ◽  
Laser Doppler Velocimetry ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Oxygen Demand ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Total Blood ◽  
Total Blood Flow

In a previous study of regional intestinal blood flow by laser-Doppler velocimetry, we noted that the mucosa displayed reactive hyperemia following arterial occlusion but that the muscularis did not. Therefore, to determine whether this observation is generally valid, we compared responses of the mucosa and muscularis externa to arterial occlusion. We measured total blood flow to isolated loops of canine small bowel with an electromagnetic flow probe on the supply artery; blood flow either in the mucosa or in the muscularis was measured by laser-Doppler velocimetry. Mucosal and total blood flow consistently showed reactive hyperemia in response to a 60-s occlusion, but the muscularis did not. To determine whether metabolic rate influenced reactive hyperemia, we increased enteric oxygen uptake by placing 5% bile and transportable solutes in the lumen; these agents increased oxygen consumption by 36%. After a 60-s occlusion, the durations of both total and mucosal reactive hyperemia were significantly prolonged by increased metabolic rate. Similarly, the payback-to-debt ratios in both total and mucosal blood flows were significantly increased at elevated metabolic rate. These data support the conclusions that reactive hyperemia occurs more frequently and has a greater magnitude in the mucosa compared with the muscularis and both total and mucosal reactive hyperemia are strongly influenced by the preocclusive oxygen demand. These findings therefore constitute further evidence that metabolic factors contribute to reactive hyperemia in the intestinal circulation.

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