scholarly journals Influence on cell death of high frequency motion of magnetic nanoparticles during magnetic hyperthermia experiments

2016 ◽  
Vol 109 (3) ◽  
pp. 032402 ◽  
Author(s):  
N. Hallali ◽  
P. Clerc ◽  
D. Fourmy ◽  
V. Gigoux ◽  
J. Carrey
Keyword(s):  
Cell Death ◽  
Magnetic Nanoparticles ◽  
High Frequency ◽  
Magnetic Hyperthermia

scholarly journals Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 438
Author(s):  
Felista L. Tansi ◽  
Filipp Fröbel ◽  
Wisdom O. Maduabuchi ◽  
Frank Steiniger ◽  
Martin Westermann ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Magnetic Nanoparticles ◽  
Tumor Stroma ◽  
Magnetic Hyperthermia ◽  
Magnetic Nanomaterials ◽  
Hyperthermia Treatment ◽  
Pancreatic Cancer Cells ◽  
Cancer Models

Magnetic hyperthermia can cause localized thermal eradication of several solid cancers. However, a localized and homogenous deposition of high concentrations of magnetic nanomaterials into the tumor stroma and tumor cells is mostly required. Poorly responsive cancers such as the pancreatic adenocarcinomas are hallmarked by a rigid stroma and poor perfusion to therapeutics and nanomaterials. Hence, approaches that enhance the infiltration of magnetic nanofluids into the tumor stroma convey potentials to improve thermal tumor therapy. We studied the influence of the matrix-modulating enzymes hyaluronidase and collagenase on the uptake of magnetic nanoparticles by pancreatic cancer cells and 3D spheroids thereof, and the overall impact on magnetic heating and cell death. Furthermore, we validated the effect of hyaluronidase on magnetic hyperthermia treatment of heterotopic pancreatic cancer models in mice. Treatment of cultured cells with the enzymes caused higher uptake of magnetic nanoparticles (MNP) as compared to nontreated cells. For example, hyaluronidase caused a 28% increase in iron deposits per cell. Consequently, the thermal doses (cumulative equivalent minutes at 43 °C, CEM43) increased by 15–23% as compared to heat dose achieved for cells treated with magnetic hyperthermia without using enzymes. Likewise, heat-induced cell death increased. In in vivo studies, hyaluronidase-enhanced infiltration and distribution of the nanoparticles in the tumors resulted in moderate heating levels (CEM43 of 128 min as compared to 479 min) and a slower, but persistent decrease in tumor volumes over time after treatment, as compared to comparable treatment without hyaluronidase. The results indicate that hyaluronidase, in particular, improves the infiltration of magnetic nanoparticles into pancreatic cancer models, impacts their thermal treatment and cell depletion, and hence, will contribute immensely in the fight against pancreatic and many other adenocarcinomas.

scholarly journals Empirical Expression for AC Magnetization Harmonics of Magnetic Nanoparticles under High-Frequency Excitation Field for Thermometry

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2506
Author(s):  
Zhongzhou Du ◽  
Dandan Wang ◽  
Yi Sun ◽  
Yuki Noguchi ◽  
Shi Bai ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
High Frequency ◽  
Planck Equation ◽  
Magnetization Dynamics ◽  
Excitation Field ◽  
Fokker Planck Equation ◽  
High Frequency Excitation ◽  
Frequency Excitation ◽  
Ac Magnetization ◽  
Fokker Planck

The Fokker–Planck equation accurately describes AC magnetization dynamics of magnetic nanoparticles (MNPs). However, the model for describing AC magnetization dynamics of MNPs based on Fokker-Planck equation is very complicated and the numerical calculation of Fokker-Planck function is time consuming. In the stable stage of AC magnetization response, there are differences in the harmonic phase and amplitude between the stable magnetization response of MNPs described by Langevin and Fokker–Planck equation. Therefore, we proposed an empirical model for AC magnetization harmonics to compensate the attenuation of harmonics amplitude induced by a high frequency excitation field. Simulation and experimental results show that the proposed model accurately describes the AC M–H curve. Moreover, we propose a harmonic amplitude–temperature model of a magnetic nanoparticle thermometer (MNPT) in a high-frequency excitation field. The simulation results show that the temperature error is less than 0.008 K in the temperature range 310–320 K. The proposed empirical model is expected to help improve MNPT performance.

scholarly journals Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaser Hadadian ◽  
Ana Paula Ramos ◽  
Theo Z. Pavan
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Linear Response Theory ◽  
Magnetic Hyperthermia ◽  
Superior Performance ◽  
Dipolar Interactions ◽  
Intrinsic Properties ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

AbstractOptimizing the intrinsic properties of magnetic nanoparticles for magnetic hyperthermia is of considerable concern. In addition, the heating efficiency of the nanoparticles can be substantially influenced by dipolar interactions. Since adequate control of the intrinsic properties of magnetic nanoparticles is not straightforward, experimentally studying the complex interplay between these properties and dipolar interactions affecting the specific loss power can be challenging. Substituting zinc in magnetite structure is considered as an elegant approach to tune its properties. Here, we present experimental and numerical simulation results of magnetic hyperthermia studies using a series of zinc-substituted magnetite nanoparticles (ZnxFe1-xFe2O4, x = 0.0, 0.1, 0.2, 0.3 and 0.4). All experiments were conducted in linear regime and the results were inferred based on the numerical simulations conducted in the framework of the linear response theory. The results showed that depending on the nanoparticles intrinsic properties, interparticle interactions can have different effects on the specific loss power. When dipolar interactions were strong enough to affect the heating efficiency, the parameter σ = KeffV/kBT (Keff is the effective anisotropy and V the volume of the particles) determined the type of the effect. Finally, the sample x = 0.1 showed a superior performance with a relatively high intrinsic loss power 5.4 nHm2kg−1.

Enhancement of docetaxel-treated MCF-7 cell death by 900-MHz radiation

2013 ◽  
Vol 8 (4) ◽  
pp. 357-365
Author(s):  
Marianna Trebuňová ◽  
Galina Laputková ◽  
Imrich Géci ◽  
Igor Andrašina ◽  
Ján Sabo
Keyword(s):  
Cell Culture ◽  
Cell Death ◽  
Electromagnetic Field ◽  
High Frequency ◽  
Input Power ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
High Frequency Electromagnetic Field ◽  
Mcf 7

AbstractThe aim of the study was to investigate the effect of high-frequency electromagnetic field of 900 MHz at 8 W input power on metabolic activity of human breast adenocarcinoma MCF-7 cells. With the aid of the colorimetric MTT assay, it was shown that there is significant change in cell culture survival exposed to docetaxel in field-free conditions in comparison with cells treated with docetaxel simultaneously exposed to high-frequency electromagnetic field.

scholarly journals Low to Very-High Frequency Ultrasound Biomicroscopy of Cell Death

2010 ◽  
Vol 16 (S2) ◽  
pp. 1110-1111
Author(s):  
GJ Czarnota
Keyword(s):  
Cell Death ◽  
High Frequency ◽  
Ultrasound Biomicroscopy ◽  
High Frequency Ultrasound ◽  
Very High Frequency ◽  
Very High ◽  
Frequency Ultrasound

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

scholarly journals High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity

EBioMedicine ◽  
2019 ◽  
Vol 44 ◽  
pp. 112-125 ◽  
Author(s):  
Veronica M. Ringel-Scaia ◽  
Natalie Beitel-White ◽  
Melvin F. Lorenzo ◽  
Rebecca M. Brock ◽  
Kathleen E. Huie ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Immunity ◽  
High Frequency ◽  
Irreversible Electroporation ◽  
Tumor Ablation

scholarly journals Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1832 ◽  
Author(s):  
Ylenia Jabalera ◽  
Francesca Oltolina ◽  
Ana Peigneux ◽  
Alberto Sola-Leyva ◽  
Maria P. Carrasco-Jiménez ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Hyperthermia ◽  
Simultaneous Application ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug ◽  
Model Drug ◽  
Drug Nanocarriers

The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

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