scholarly journals Multiplexed immunosensing and kinetics monitoring in nanofluidic devices with highly enhanced target capture efficiency

2016 ◽  
Vol 10 (3) ◽  
pp. 034114 ◽  
Author(s):  
Yii-Lih Lin ◽  
Yen-Jun Huang ◽  
Pattamon Teerapanich ◽  
Thierry Leïchlé ◽  
Chia-Fu Chou
Keyword(s):  
Capture Efficiency ◽  
Target Capture ◽  
Nanofluidic Devices ◽  
Kinetics Monitoring

scholarly journals Study on Installation Standards of Reduction Facilities considering Flow Condition of Small Drainage

2020 ◽  
Vol 20 (6) ◽  
pp. 379-387
Author(s):  
Youngseok Song ◽  
Jingul Joo ◽  
Hayong Kim ◽  
Sangman Jeong ◽  
Moojong Park
Keyword(s):  
Froude Number ◽  
Urban Areas ◽  
Capture Efficiency ◽  
Flow Conditions ◽  
Experimental Conditions ◽  
Cross Sectional ◽  
Independent Variables ◽  
Target Capture ◽  
Reduction Effect ◽  
Supply Capacity

While drainage installed in mountainous and urban areas play various roles for supplying and draining water, the standards for reduction facilities and maintenance are insufficient. In the case of small drainage, if there is an inflow of deposited debris, overflow damage occurs due to lack of water supply capacity. In this study, a reduction facility was developed to block the transport of debris in a small drainage. The equation considering installation standards was proposed by analyzing capture efficiency through hydraulic experiment. By establishing various experimental conditions, a total of 900 experiments were conducted using 90 different conditions. The reduction effect of reduction facilities was analyzed by consideration of flow conditions such as discharge and Froude Number. Multiple regression analysis was conducted to develop an equation that considers the installation standard of a small drainage. The dependent variable was capture efficiency, and the independent variables were discharge, Froude Number, and an effective cross sectional area of reduction facilities. The equation considering installation standard of small drainage is E = 1.337-5.074×Q-0.156F<sub>r</sub>-132.710A and the significance is high. The results of this study are expected to be applied to reduction facilities suitable for target capture efficiency targeting small drainage.

scholarly journals Performance comparison of four types of target enrichment baits for exome DNA sequencing

Hereditas ◽  
2021 ◽  
Vol 158 (1) ◽  
Author(s):  
Juan Zhou ◽  
Mancang Zhang ◽  
Xiaoqi Li ◽  
Zhuo Wang ◽  
Dun Pan ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Deep Sequencing ◽  
Gc Content ◽  
Performance Comparison ◽  
Capture Efficiency ◽  
Next Generation ◽  
Double Stranded Rna ◽  
Target Capture ◽  
Binding Power ◽  
Generation Sequencing

Abstract Background Next-generation sequencing technology is developing rapidly and target capture sequencing has become an important technique. Several different platforms for library preparation and target capture with different bait types respectively are commercially available. Here we compare the performance of the four platforms with different bait types to find out their advantages and limitations. The purpose of this study is to help investigators and clinicians select the appropriate platform for their particular application and lay the foundation for the development of a better target capture platform for next-generation sequencing. Results We formulate capture efficiency as a novel parameter that can be used to better evaluations of specificity and coverage depth among the different capture platforms. Target coverage, capture efficiency, GC bias, AT Dropout, sensitivity in single nucleotide polymorphisms, small insertions and deletions detection, and the feature of each platform were compared for low input samples. In general, all platforms perform well and small differences among them are revealed. In our results, RNA baits have stronger binding power than DNA baits, and with ultra deep sequencing, double stranded RNA baits perform better than single stranded RNA baits in all aspects. DNA baits got better performance in the region with high GC content and RNA baits got lower AT dropout suggesting that the binding power is different between DNA and RNA baits to genome regions with different characteristics. Conclusions The platforms with double stranded RNA baits have the most balanced capture performance. Our results show the key differences in performance among the four updated platforms with four different bait types. The better performance of double stranded RNA bait with ultra deep sequencing suggests that it may improve the sensitivity of ultra low frequent mutation detection. In addition, we further propose that the mixed baits of double stranded RNA and single stranded DNA may improve target capture performance.

scholarly journals A Numerical Study of the Effect of Particle Size on Particle Deposition on Turbine Vanes and Blades

2021 ◽  
Vol 13 (5) ◽  
pp. 168781402110178
Author(s):  
Zhengang Liu ◽  
Weinan Diao ◽  
Zhenxia Liu ◽  
Fei Zhang
Keyword(s):  
Particle Size ◽  
Particle Deposition ◽  
Numerical Study ◽  
Stokes Number ◽  
Capture Efficiency ◽  
Particle Capture ◽  
Factors Affecting ◽  
Pressure Surface ◽  
Deposition Area ◽  
Turbine Vanes

Particle deposition could decrease the aerodynamic performance and cooling efficiency of turbine vanes and blades. The particle motion in the flow and its temperature are two important factors affecting its deposition. The size of the particle influences both its motion and temperature. In this study, the motion of particles with the sizes from 1 to 20 μm in the first stage of a turbine are firstly numerically simulated with the steady method, then the particle deposition on the vanes and blades are numerically simulated with the unsteady method based on the critical viscosity model. It is discovered that the particle deposition on vanes mainly formed near the leading and trailing edge on the pressure surface, and the deposition area expands slowly to the whole pressure surface with the particle size increasing. For the particle deposition on blades, the deposition area moves from the entire pressure surface toward the tip with the particle size increasing due to the effect of rotation. For vanes, the particle capture efficiency increases with the particle size increasing since Stokes number and temperature of the particle both increase with its size. For blades, the particle capture efficiency increases firstly and then decreases with the particle size increasing.

scholarly journals Tannic acid-functionalized HEPA filter materials for influenza virus capture

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Subin Kim ◽  
Jinhyo Chung ◽  
Sang Hyun Lee ◽  
Jeong Hyeon Yoon ◽  
Dae-Hyuk Kweon ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Tannic Acid ◽  
High Efficiency ◽  
Influenza Viruses ◽  
Capture Efficiency ◽  
Protective Equipment ◽  
Filter Materials ◽  
Washing Process ◽  
Pathogenic Viruses ◽  
Cost Efficient

AbstractInfluenza, one of the most contagious and infectious diseases, is predominantly transmitted through aerosols, leading to the development of filter-based protective equipment. Though the currently available filters are effective at removing submicron-sized particulates, filter materials with enhanced virus-capture efficiency are still in demand. Coating or chemically modifying filters with molecules capable of binding influenza viruses has received attention as a promising approach for the production of virus-capturing filters. For this purpose, tannic acid (TA), a plant-derived polyphenol, is a promising molecule for filter functionalization because of its antiviral activities and ability to serve as a cost-efficient adhesive for various materials. This study demonstrates the facile preparation of TA-functionalized high-efficiency particulate air (HEPA) filter materials and their efficiency in influenza virus capture. Polypropylene HEPA filter fabrics were coated with TA via a dipping/washing process. The TA-functionalized HEPA filter (TA-HF) exhibits a high in-solution virus capture efficiency of up to 2,723 pfu/mm2 within 10 min, which is almost two orders of magnitude higher than that of non-functionalized filters. This result suggests that the TA-HF is a potent anti-influenza filter that can be used in protective equipment to prevent the spread of pathogenic viruses.

scholarly journals Optimization of Nanofluidic Devices for Geometry‐Induced Electrostatic Trapping (Part. Part. Syst. Charact. 2/2021)

2021 ◽  
Vol 38 (2) ◽  
pp. 2170003
Author(s):  
Deepika Sharma ◽  
Roderick Y. H. Lim ◽  
Thomas Pfohl ◽  
Yasin Ekinci
Keyword(s):  
Nanofluidic Devices ◽  
Electrostatic Trapping

scholarly journals Controlled Synthesis of Metal–Organic Frameworks in Scalable Open-Porous Contactor for Maximizing Carbon Capture Efficiency

JACS Au ◽  
2021 ◽  
Author(s):  
Young Hun Lee ◽  
YongSung Kwon ◽  
Chaehoon Kim ◽  
Young-Eun Hwang ◽  
Minkee Choi ◽  
...  
Keyword(s):  
Carbon Capture ◽  
Metal Organic Frameworks ◽  
Capture Efficiency ◽  
Controlled Synthesis ◽  
Metal Organic
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