scholarly journals Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices

2016 ◽  
Vol 10 (2) ◽  
pp. 024125 ◽  
Author(s):  
Andrew V. Ewing ◽  
Graham S. Clarke ◽  
Sergei G. Kazarian
Keyword(s):  
Fourier Transform ◽  
Spectroscopic Imaging ◽  
Microfluidic Devices ◽  
Fourier Transform Infrared ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

Time-Resolved Fourier Transform Infrared Spectroscopic Imaging

2003 ◽  
Vol 57 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Rohit Bhargava ◽  
Ira W. Levin
Keyword(s):  
Fourier Transform ◽  
Imaging Modality ◽  
Spectroscopic Imaging ◽  
Fourier Transform Infrared ◽  
Dynamic Processes ◽  
Time Resolved ◽  
Ir Imaging ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging ◽  
Ft Ir

Fourier transform infrared (FT-IR) imaging allows simultaneous spectral characterization of large spatial areas due to its multichannel detection advantage. The acquisition of large amounts of data in the multichannel configuration results, however, in a poor temporal resolution of sequentially acquired data sets, which limits the examination of dynamic processes to processes that have characteristic time scales of the order of minutes. Here, we introduce the concept and instrumental details of a time-resolved infrared spectroscopic imaging modality that permits the examination of repetitive dynamic processes whose half-lives are of the order of milliseconds. As an illustration of this implementation of step-scan FT-IR imaging, we examine the molecular responses to external electric-field perturbations of a microscopically heterogeneous polymer–liquid crystal composite. Analysis of the spectroscopic data using conventional univariate and generalized two-dimensional (2D) correlation methods emphasizes an additional capability for accessing of simultaneous spatial and temporal chemical measurements of molecular dynamic processes.

Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells

2016 ◽  
Vol 45 (7) ◽  
pp. 1850-1864 ◽  
Author(s):  
K. L. Andrew Chan ◽  
Sergei G. Kazarian
Keyword(s):  
Fourier Transform ◽  
Spectroscopic Imaging ◽  
Fourier Transform Infrared ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Live Cells ◽  
Ftir Imaging ◽  
Recent Advances

Recent advances and emerging applications of ATR-FTIR spectroscopic imaging for analysis of biomedical samples have been reviewed.

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