Examining the role of the tectorial membrane in otoacoustic emission generation

2015 ◽  
Author(s):  
Marry Ann Cheatham ◽  
Richard J. Goodyear ◽  
Karolina K. Charaziak ◽  
Tess Conklin ◽  
Jing Zheng ◽  
...  
Keyword(s):  
Otoacoustic Emission ◽  
Tectorial Membrane

The role of tectorial membrane stiffness and viscosity on traveling waves and resonance

2015 ◽  
Author(s):  
Shirin Farrahi ◽  
Jonathan B. Sellon ◽  
Roozbeh Ghaffari ◽  
Dennis M. Freeman
Keyword(s):  
Traveling Waves ◽  
Tectorial Membrane ◽  
Membrane Stiffness

scholarly journals The Role of Prestin in the Generation of Electrically Evoked Otoacoustic Emissions in Mice

2008 ◽  
Vol 99 (4) ◽  
pp. 1607-1615 ◽  
Author(s):  
Markus Drexl ◽  
Marcia M. Mellado Lagarde ◽  
Jian Zuo ◽  
Andrei N. Lukashkin ◽  
Ian J. Russell
Keyword(s):  
Hair Cells ◽  
Otoacoustic Emissions ◽  
Temporal Structure ◽  
Organ Of Corti ◽  
Outer Hair Cells ◽  
Tectorial Membrane ◽  
Wild Type ◽  
Short Delay ◽  
Delay Component

Electrically evoked otoacoustic emissions are sounds emitted from the inner ear when alternating current is injected into the cochlea. Their temporal structure consists of short- and long-delay components and they have been attributed to the motile responses of the sensory-motor outer hair cells of the cochlea. The nature of these motile responses is unresolved and may depend on either somatic motility, hair bundle motility, or both. The short-delay component persists after almost complete elimination of outer hair cells. Outer hair cells are thus not the sole generators of electrically evoked otoacoustic emissions. We used prestin knockout mice, in which the motor protein prestin is absent from the lateral walls of outer hair cells, and Tecta ΔENT/ΔENT mice, in which the tectorial membrane, a structure with which the hair bundles of outer hair cells normally interact, is vestigial and completely detached from the organ of Corti. The amplitudes and delay spectra of electrically evoked otoacoustic emissions from Tecta ΔENT/ΔENT and Tecta +/+ mice are very similar. In comparison with prestin +/+ mice, however, the short-delay component of the emission in prestin −/− mice is dramatically reduced and the long-delay component is completely absent. Emissions are completely suppressed in wild-type and Tecta ΔENT/ΔENT mice at low stimulus levels, when prestin-based motility is blocked by salicylate. We conclude that near threshold, the emissions are generated by prestin-based somatic motility.

Role of the Tectorial Membrane Revealed by Otoacoustic Emissions Recorded From Wild-Type and Transgenic TectaΔENT/ΔENT Mice

2004 ◽  
Vol 91 (1) ◽  
pp. 163-171 ◽  
Author(s):  
Andrei N. Lukashkin ◽  
Victoria A. Lukashkina ◽  
P. Kevin Legan ◽  
Guy P. Richardson ◽  
Ian J. Russell
Keyword(s):  
Otoacoustic Emissions ◽  
Low Frequency ◽  
Tectorial Membrane ◽  
Local Minima ◽  
Wild Type ◽  
Distortion Product ◽  
Growth Functions ◽  
In The Wild ◽  
Surrounding Fluid

Distortion product otoacoustic emissions (DPOAE) were recorded from wild-type mice and mutant TectaΔ ENT/Δ ENT mice with detached tectorial membranes (TM) under combined ketamine/xylaxine anesthesia. In TectaΔ ENT/Δ ENT mice, DPOAEs could be detected above the noise floor only when the levels of the primary tones exceeded 65 dB SPL. DPOAE amplitude decreased with increasing frequency of the primaries in TectaΔ ENT/Δ ENT mice. This was attributed to hair cell excitation via viscous coupling to the surrounding fluid and not by interaction with the TM as in the wild-type mice. Local minima and corresponding phase transitions in the DPOAE growth functions occurred at higher DPOAE levels in wild-type than in TectaΔ ENT/Δ ENT mice. In less-sensitive TectaΔ ENT/Δ ENT mice, the position of the local minima varied nonsystematically with frequency or no minima were observed. A bell-like dependence of the DPOAE amplitude on the ratio of the primaries was recorded in both wild-type and TectaΔ ENT/Δ ENT mice. However, the pattern of this dependence was different in the wild-type and TectaΔ ENT/Δ ENT mice, an indication that the bell-like shape of the DPOAE was produced by a combination of different mechanisms. A nonlinear low-frequency resonance, revealed by nonmonotonicity of the phase behavior, was seen in the wild-type but not in TectaΔ ENT/Δ ENT mice.

Otoacoustic emission in myasthenia gravis patients and the role of efferent activation

1998 ◽  
Vol 126 (1-2) ◽  
pp. 123-125 ◽  
Author(s):  
László Tóth ◽  
Tamás Rácz ◽  
Péter Diószeghy ◽  
Gábor Répássy ◽  
István Lampé
Keyword(s):  
Myasthenia Gravis ◽  
Otoacoustic Emission

Nanofluidics of Mammalian Hearing

2011 ◽  
Author(s):  
Sonya T. Smith ◽  
Richard Chadwick
Keyword(s):  
Ion Channels ◽  
Hair Cell ◽  
Flow Patterns ◽  
Hair Bundle ◽  
Tectorial Membrane ◽  
Inner Hair Cell ◽  
Fluid Shear ◽  
Acoustic Stimuli ◽  
Molecular Gates

The inner hair cell stereocilia bundle performs the role of transducer in mammalian hearing. Acoustic stimuli deflect the hair bundle to open ion channels, resulting in cation influx and the subsequent release of a neurotransmitter at the base of the cell. Hypotheses for this transduction include fluid shear-driven motion between the tectorial membrane and the reticular lamina to deflect the bundle. It is presumed that ‘molecular gates’ sense tension in tip-links that connect adjacent stepped rows of stereocilia to open the channels. However, almost nothing is known about the endolymphatic flow in the micron-sized gap surrounding the bundle and the nanoscale sized gaps between individual stereocilia rows and between individual bundles. Here we show with nanometer resolution, how each row of stereocilia, their associated tip links and gates and the corresponding flow patterns move in response to acoustical input.

scholarly journals Role of Otoacoustic Emission Test in Neonatal Screening at Tertiary Center

2019 ◽  
Vol 71 (S2) ◽  
pp. 1535-1537
Author(s):  
Shiv Kumar Raghuwanshi ◽  
Aditya Gargava ◽  
Vikram Kulkarani ◽  
Ajit Kumar
Keyword(s):  
Neonatal Screening ◽  
Otoacoustic Emission ◽  
Tertiary Center
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