scholarly journals The mean shape of transition and first-passage paths

2015 ◽  
Vol 143 (22) ◽  
pp. 224108 ◽  
Author(s):  
Won Kyu Kim ◽  
Roland R. Netz
Keyword(s):  
1980 ◽  
Vol 45 (3) ◽  
pp. 777-782 ◽  
Author(s):  
Milan Šolc

The establishment of chemical equilibrium in a system with a reversible first order reaction is characterized in terms of the distribution of first passage times for the state of exact chemical equilibrium. The mean first passage time of this state is a linear function of the logarithm of the total number of particles in the system. The equilibrium fluctuations of composition in the system are characterized by the distribution of the recurrence times for the state of exact chemical equilibrium. The mean recurrence time is inversely proportional to the square root of the total number of particles in the system.


2017 ◽  
Vol 37 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Shenghong Li ◽  
Yong Huang

In this paper, the mean first-passage time of a delayed tumor cell growth system driven by colored cross-correlated noises is investigated. Based on the Novikov theorem and the method of probability density approximation, the stationary probability density function is obtained. Then applying the fastest descent method, the analytical expression of the mean first-passage time is derived. Finally, effects of different kinds of delays and noise parameters on the mean first-passage time are discussed thoroughly. The results show that the time delay included in the random force, additive noise intensity and multiplicative noise intensity play a positive role in the disappearance of tumor cells. However, the time delay included in the determined force and the correlation time lead to the increase of tumor cells.


1982 ◽  
Vol 29 (8) ◽  
pp. 1027-1040 ◽  
Author(s):  
P.M. Kiely ◽  
G. Smith ◽  
L.G. Carney
Keyword(s):  

2019 ◽  
Author(s):  
Vishal Singh ◽  
Parbati Biswas

Protein aggregation is investigated theoretically via protein turnover, misfolding, aggregation and degradation. The Mean First Passage Time (MFPT) of aggregation is evaluated within the framework of Chemical Master Equation (CME) and pseudo first order kinetics with appropriate boundary conditions. The rate constants of aggregation of different proteins are calculated from the inverse MFPT, which show an excellent match with the experimentally reported rate constants and those extracted from the ThT/ThS fluorescence data. Protein aggregation is found to be practically independent of the number of contacts and the critical number of misfolded contacts. The age of appearance of aggregation-related diseases is obtained from the survival probability and the MFPT results, which matches with those reported in the literature. The calculated survival probability is in good agreement with the only available clinical data for Parkinson’s disease.<br>


Author(s):  
Xiaoyan Li ◽  
Yu Sun

In this paper, we introduce a class of double-weighted polygon networks with two different meanings of weighted factors [Formula: see text] and [Formula: see text], which represent path-difficulty and path-length, respectively, based on actual traffic networks. Picking an arbitrary node from the hub nodes set as the trap node, and the double-weighted polygon networks are divided into [Formula: see text] blocks by combining with the iterative method. According to biased random walks, the calculation expression of average receiving time (ART) of any polygon networks is given by using the intermediate quantity the mean first-passage time (MFPT), which is applicable to any [Formula: see text] ([Formula: see text]) polygon networks. What is more, we display the specific calculation process and results of ART of the double-weighted quadrilateral networks, indicating that ART grows exponentially with respect to the networks order and the exponent is [Formula: see text] which grows with the product of [Formula: see text]. When [Formula: see text] increases, ART increases linearly ([Formula: see text]) or sublinearly ([Formula: see text]) with the size of networks, and the smaller value of [Formula: see text], the higher transportation efficiency.


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