Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density

2015 ◽  
Vol 22 (12) ◽  
pp. 122004 ◽  
Author(s):  
Hiromasa Tanaka ◽  
Masaaki Mizuno ◽  
Shinya Toyokuni ◽  
Shoichi Maruyama ◽  
Yasuhiro Kodera ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Electron Density ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
High Electron ◽  
High Electron Density ◽  
Pressure Plasma

scholarly journals Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

2020 ◽  
Vol 10 (19) ◽  
pp. 6898
Author(s):  
Lars Boeckmann ◽  
Mirijam Schäfer ◽  
Thoralf Bernhardt ◽  
Marie Luise Semmler ◽  
Ole Jung ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Therapeutic Effects ◽  
Preclinical Research ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.

Nonequilibrium atmospheric pressure plasma with ultrahigh electron density and high performance for glass surface cleaning

2008 ◽  
Vol 92 (8) ◽  
pp. 081503 ◽  
Author(s):  
Masahiro Iwasaki ◽  
Hirotoshi Inui ◽  
Yuto Matsudaira ◽  
Hiroyuki Kano ◽  
Naofumi Yoshida ◽  
...  
Keyword(s):  
Electron Density ◽  
Atmospheric Pressure ◽  
Glass Surface ◽  
High Performance ◽  
Atmospheric Pressure Plasma ◽  
Surface Cleaning ◽  
Pressure Plasma

scholarly journals Laser-induced photodetachment of negative oxygen ions in the spatial afterglow of an atmospheric pressure plasma jet

2022 ◽  
Author(s):  
Tim Jacobus Adrianus Staps ◽  
Tim Jacobus Maria Donders ◽  
Bart Platier ◽  
J Beckers
Keyword(s):  
Electron Density ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Negative Ions ◽  
Plasma Jet ◽  
Ambient Air ◽  
Microwave Cavity ◽  
Oxygen Mixture ◽  
Atmospheric Pressure Plasma Jet ◽  
Pressure Plasma

Abstract Negative ions are an important constituent of the spatial afterglow of atmospheric pressure plasmas, where the fundamental plasma-substrate interactions take place that are vital for applications such as biomedicine, material synthesis, and ambient air treatment. In this work, we use laser-induced photodetachment to liberate electrons from negative ions in the afterglow region of an atmospheric pressure plasma jet interacting with an argon-oxygen mixture, and microwave cavity resonance spectroscopy (MCRS) to detect the photodetached electrons. This diagnostic technique allows for the determination of the electron density and the effective collision frequency before, during and after the laser pulse was shot through the measurement volume with nanosecond time resolution. From a laser saturation study, it is concluded that O− is the dominant negative ion in the afterglow. Moreover, the decay of the photodetached electron density is found to be dominantly driven by the (re)formation of O− by dissociative attachment of electrons with O2. As a consequence, we identified the species and process responsible for the formation of negative ions in the spatial afterglow in our experiment.

Influence of different O2/H2O ratios on He atmospheric pressure plasma jet impinging on a dielectric surface

2021 ◽  
Author(s):  
Jie Liu ◽  
Lijun Wang ◽  
Xin Lin ◽  
Runming Zhang
Keyword(s):  
Electron Density ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Plasma Jet ◽  
Dielectric Surface ◽  
Ionization Wave ◽  
Electron Collision ◽  
Recombination Reaction ◽  
Atmospheric Pressure Plasma Jet ◽  
Pressure Plasma

Abstract A two dimensional (2D) axisymmetric fluid model is built to investigate the effect of different O2 and H2O admixture on the plasma dynamics and the distribution of reactive species in He atmospheric pressure plasma jet (APPJ). The increase of O2: H2O ratio slows down both the intensity and the propagation speed of ionization wave. Due to the decrease of both H2O ionization rate and H2O Penning ionization as well as the stronger electronegativity of O2, the increase of O2: H2O ratio results in a significant reduction of electron density in the APPJ, which restricts the occurrence of electron collision ionization reactions and inhibits the propagation of plasma. The excitation energy loss of O2 is not the reason for the weakening of the plasma ionization wave. The densities of O2+, O- and O2- increase with the rise of O2 admixture while H2O+ decreases due to the decrease of electron density and H2O concentration. OH- density is affected by both the increase of O- and the decrease of H2O so it shows peak in the case of O2: H2O=7:3. O is mainly produced by the excitation reactions and the electron recombination reaction (e + O2+ → 2O), which is directly related to the O2 concentration. OH is mainly produced by e + H2O → e + H + OH so the OH density decreases due to the decrease of electron density and H2O concentration with the increase of O2: H2O ratio. On the dielectric surface when the propagation of streamer extinguishes, O flux shows an upward trend while the OH flux decreases, and the propagation distance of O and OH decreases with the increase of O2: H2O ratio.

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