scholarly journals Unstable spiral waves and local Euclidean symmetry in a model of cardiac tissue

2015 ◽  
Vol 25 (6) ◽  
pp. 063116 ◽  
Author(s):  
Christopher D. Marcotte ◽  
Roman O. Grigoriev
Keyword(s):  
Cardiac Tissue ◽  
Spiral Waves ◽  
Euclidean Symmetry

Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model

2008 ◽  
Vol 25 (7) ◽  
pp. 2706-2709 ◽  
Author(s):  
Yu Lian-Chun ◽  
Ma Jun ◽  
Zhang Guo-Yong ◽  
Chen Yong
Keyword(s):  
Voltage Clamp ◽  
Cardiac Tissue ◽  
Spiral Waves ◽  
Tissue Model

VULNERABILITY TO REENTRY, AND DRIFT, STABILITY AND BREAKDOWN OF SPIRAL WAVES IN A LINEAR GRADIENT OF GK IN A LUO–RUDY 1 VIRTUAL VENTRICULAR TISSUE

2003 ◽  
Vol 13 (12) ◽  
pp. 3865-3871 ◽  
Author(s):  
O. V. ASLANIDI ◽  
R. H. CLAYTON ◽  
A. V. HOLDEN ◽  
H. K. PHILLIPS ◽  
R. J. WARD
Keyword(s):  
Action Potential ◽  
Velocity Component ◽  
Action Potential Duration ◽  
Cardiac Tissue ◽  
Spiral Wave ◽  
Spiral Waves ◽  
Linear Gradient ◽  
Wave Solutions ◽  
Ventricular Tissue ◽  
Vulnerable Window

The vulnerable window in a heterogeneous virtual LRl cardiac tissue, with a linear gradient in GK, is wider when following propagation down the gradient, towards tissue with longer action potential duration, than when following propagation up the gradient. Spiral wave solutions in a uniform linear gradient in GK drift, with a velocity component along the gradient of the order of mm/s, towards tissue with a longer APD.

scholarly journals A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue

2011 ◽  
Vol 44 (8) ◽  
pp. 633-639 ◽  
Author(s):  
Binbin Xu ◽  
Sabir Jacquir ◽  
Gabriel Laurent ◽  
Jean-Marie Bilbault ◽  
Stéphane Binczak
Keyword(s):  
Cardiac Tissue ◽  
Spiral Waves

scholarly journals Suppressions of spiral waves and spatiotemporal chaos in cardiac tissue

2012 ◽  
Vol 61 (10) ◽  
pp. 100504
Author(s):  
Kuang Yu-Lan ◽  
Tang Guo-Ning
Keyword(s):  
Cardiac Tissue ◽  
Spatiotemporal Chaos ◽  
Spiral Waves

SPATIOTEMPORAL IRREGULARITY IN A TWO-DIMENSIONAL MODEL OF CARDIAC TISSUE

1991 ◽  
Vol 01 (01) ◽  
pp. 219-225 ◽  
Author(s):  
A. V. PANFILOV ◽  
A. V. HOLDEN
Keyword(s):  
Cardiac Tissue ◽  
Numerical Solutions ◽  
Spiral Waves ◽  
Excitable Medium ◽  
Two Dimensional ◽  
Dimensional Model ◽  
Two Dimensional Model ◽  
Solutions Of Equations

Meandering spiral waves are well-known solutions of equations that represent a two-dimensional excitable medium. Numerical solutions of a model for a sheet of cardiac tissue show transient meandering vortices that break down spontaneously into spatiotemporal irregularity.

Abstract 1349: Overexpression And Dominant-negative Suppression Of Inwardly Rectifying Potassium Channel Protein (Kir2.1) Alters Electrophysiology And Spiral Wave Dynamics Of An In Vitro Model Of Cardiac Myocytes

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Rajesh B Sekar ◽  
Eddy Kizana ◽  
Hee C Cho ◽  
Rachel R Smith ◽  
Brett P Eaton ◽  
...  
Keyword(s):  
Cardiac Tissue ◽  
Spiral Waves ◽  
Dominant Negative ◽  
Neonatal Rat ◽  
Resting Potential ◽  
Dominant Negative Mutant ◽  
Rapid Pacing ◽  
The Stability ◽  
Inwardly Rectifying

Introduction : An important role for the inwardly rectifying potassium current (I K1 ) has been postulated in controlling the stability and frequency of rotors responsible for ventricular tachycardia and fibrillation. We investigated the effects of Kir2.1 overexpression and Kir2.1AAA dominant-negative mutant suppression on the electrophysiology and inducibility, stability and frequency of spiral waves in an in vitro cardiac tissue model. Methods/Results : Neonatal rat ventricular myocytes (NRVMs) were transduced by lentiviral vectors encoding Kir2.1 or Kir2.1AAA. Immunostaining revealed Kir2.1 or mutant Kir2.1 protein overexpression and whole cell-clamp confirmed the predicted effects on I K1 , resting potential, and action potential duration (APD 80 ). Optical mapping was performed on confluent NRVM monolayers containing a 5 mm diameter central island of gene-modified NRVMs created by a stenciling technique. APs propagated with increased CV (25.1±2.7 cm/sec, n=7) and shortened APD 80 (73±11 msec, n=7) in islands of Kir2.1 overexpression, or decreased CV (13.1±1.1 cm/sec, n=7) and prolonged APD 80 (263±14 msec, n=7) in islands of Kir2.1AAA suppression, compared with normal CV and APD 80 of 19.2±0.4 cm/sec and 169±14 msec (n=7) in non-transduced islands. Reentry was initiated by rapid pacing. With Kir2.1 overexpression, reentrant waves anchored to the island and remained stable (89±15 minutes, n=3) with a frequency of 8±2 Hz. Superfusion with 0.5 mM BaCl 2 to block I K1 slowed reentry to 1 Hz and terminated it shortly after initiation. NRVM monolayers with islands of Kir2.1AAA suppression (n=3) displayed rapid spontaneous activity. Rapid pacing of these monolayers initiated an unstable figure-of-eight reentry (n=3) that degraded into single and multi-armed spiral waves, anchored to varying parts of the island with a maximum frequency of 2±1 Hz. Importantly, no reentry could be initiated in monolayers with non-transduced islands (n=3). Conclusion : Functional reentrant waves induced by rapid pacing are anchored to islands of localized Kir2.1 overexpression whereas they drop in frequency and meander in islands of dominant-negative suppression of Kir2.1, confirming the importance of I K1 for the stability of these waves in cardiac tissue.

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