Anatomy of the prostate having centrally located urethra detects that the radioactive seeds be distributed peripherally for prescribed dose coverage to the prostate and minimal dose to the urethra. Additionally, dose to the rectum should be minimal without sacrificing does coverage to the prostate. In conventional low-dose-rate (LDR) brachytherapy approach, seeds are delivered in prostate through needles inserted rectilinearly with limited flexibility and maneuverability (Fig. 1a).
Impact of a large breast separation on radiation dose delivery to the ipsilateral lung as result of respiratory motion quantified using free breathing and 4D CT-based planning in patients with locally advanced breast cancers: A potential for adverse clinical implications