Potential role of ABC-assisted repositories in U.S. plutonium and high-level waste disposition

1995 ◽  
Author(s):  
David Berwald ◽  
Anthony Favale ◽  
Timothy Myers ◽  
Jerry McDaniel
Keyword(s):  
Potential Role ◽  
High Level Waste ◽  
High Level

scholarly journals A Transport Code for Radiocolloid Migration: With an Assessment of an Actual Low-Level Waste Site

1984 ◽  
Vol 44 ◽  
Author(s):  
Bryan J. Travis ◽  
H. E. Nuttall
Keyword(s):  
High Level Waste ◽  
Waste Site ◽  
Low Level ◽  
Transport Code ◽  
Experimental Laboratory ◽  
Rapid Transport ◽  
High Level ◽  
Waste Repositories ◽  
Low Level Radioactive Waste

AbstractRecently, there is increased concern that radiocolloids may act as a rapid transport mechanism for the release of radionuclides from high-level waste repositories. The role of colloids is, however, controversial because the necessary data and assessment methodology have been limited. To quantitatively assess the role of colloids, the TRACR3D transport code has been enhanced by the addition of the population balance equations. The code was tested against the experimental laboratory column data of Avogadro et al. Next a low-level radioactive waste site was investigated to explore whether colloid migration could account for the unusually rapid transport of plutonium and americium observed. The nature and modeling of radiocolloids are discussed along with site simulation results from the TRACR3D code.

scholarly journals Alteration of Neuregulin 1/Erbb4 in Absence Epilepsy: Regulatory Effect on TRPV1 Expression

2021 ◽  
Author(s):  
Farideh Talebi ◽  
◽  
Samira Ghorbani ◽  
Leila Alizadeh ◽  
Fatemeh Akhlaghi ◽  
...  
Keyword(s):  
Protein Level ◽  
Neurological Disorders ◽  
Wistar Rats ◽  
Potential Role ◽  
Absence Epilepsy ◽  
Regulatory Effect ◽  
Neuregulin 1 ◽  
Erbb4 Receptor ◽  
High Level

The footprint of Neuregulin 1 (NRG1) / ERbB4 in the pathophysiology of some neurological disorders and TRPV1 regulation has been indicated. The alterations of NRG1 and ErbB4 as well as TRPV1 signaling pathway was investigated during development of absence epilepsy in the genetic animal model of absence epilepsy. Male WAG/Rij and Wistar rats were divided into four experimental groups of 2 and 6 months of age. The protein level of NRG1, ERbB4 and TRPV1 were measured in the somatosensory cortex and hippocampus. The cortical protein level of NRG1 and ErbB4 in the 6-month-old WAG/Rij rats was lower than Wistar rats. Protein level of TRPV1 was lower in 2- and 6-month-old WAG/Rij rats compared to age-matched Wistar rats. Hippocampal protein level of NRG1 in 6-month-old WAG/Rij rats was lower than 2-month-old WAG/Rij rats. Low level of ErbB4 protein in 2-month-old and high level in 6-month-old WAG/Rij rats was shown compared to Wistar rats. Protein level of TRPV1 was lower in the 2-month-old and higher in 6-month- old WAG/Rij rats compared to age-matched Wistar rats. Furthermore, high correlation between NRG1/ERbB4 and TRPV1 expressions in the cortex and hippocampus was indicated. The expression of NRG1/ERbB4 and TRPV1 followed a similar pattern during life span of Wistar and WAG/Rij rats.Our findings indicated the potential role of NRG1/ErbB4 pathway as well as TRPV1 in the pathogenesis of absence epilepsy. The regulatory effect of ERbB4 receptor on the TRPV1 expression has been suggested following by the similarity pattern of expression.

scholarly journals Wearing your Heart on your Screen: Investigating Congruency-effects in Autonomic Responses and their Role in Interoceptive Processing during Biofeedback

2019 ◽  
Author(s):  
Lilla Hodossy ◽  
Manos Tsakiris
Keyword(s):  
Potential Role ◽  
Sense Of Self ◽  
Predictive Coding ◽  
Autonomic Responses ◽  
Low Level ◽  
Autonomic Changes ◽  
Hierarchical Levels ◽  
The Stability ◽  
High Level

The experience of one’s embodied sense of self is dependent on the integration of signals originating both from within and outwith one’s body. During the processing and integration of these signals, the bodily self must maintain a fine balance between stability and malleability. Here we investigate the potential role of autonomic responses in interoceptive processing and their contribution to the stability of the bodily self. Using a biofeedback paradigm, we manipulated the congruency of cardiac signals across two hierarchical levels: (i) the low-level congruency between a visual feedback and participant’s own cardiac signal and (ii) the high-level congruency between the participants’ beliefs about the identity of the cardiac feedback and its true identity. We measured the effects of these manipulations on high-frequency heart rate variability (HF-HRV), a selective index of phasic vagal cardiac control. In Experiment 1, HF-HRV was sensitive to low-level congruency, independently of whether participants attempted to regulate or simply attend to the biofeedback. Experiment 2 revealed a higher-level congruency effect, as participants’ prior veridical beliefs increased HF-HRV while when false they decreased HF-HRV. Our results demonstrate that autonomic changes in HF-HRV are sensitive to congruencies across multiple hierarchical levels. Our findings have important theoretical implications for predictive coding models of the self as they pave the way for a more direct way to track the subtle changes in the co-processing of the internal and external milieus.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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