scholarly journals A semi-automated, field-portable microscopy platform for clinical diagnostic applications

AIP Advances ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. 084902 ◽  
Author(s):  
Veerendra Kalyan Jagannadh ◽  
Rajesh Srinivasan ◽  
Sai Siva Gorthi
Keyword(s):  
Clinical Diagnostic ◽  
Diagnostic Applications

Chip-Based Heterogeneous Immunoassay for Clinical Diagnostic Applications

1998 ◽  
pp. 347-350 ◽  
Author(s):  
K. Fluri ◽  
G.-L. Lettieri ◽  
B. H. van der Schoot ◽  
E. Verpoorte ◽  
N. F. de Rooij
Keyword(s):  
Clinical Diagnostic ◽  
Heterogeneous Immunoassay ◽  
Diagnostic Applications

Nitrogen-doped carbon nanoparticle modulated turn-on fluorescent probes for histidine detection and its imaging in living cells

Nanoscale ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 2205-2211 ◽  
Author(s):  
Xiaohua Zhu ◽  
Tingbi Zhao ◽  
Zhou Nie ◽  
Zhuang Miao ◽  
Yang Liu ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Living Cells ◽  
Selective Detection ◽  
Carbon Nanoparticle ◽  
Nitrogen Doped ◽  
Turn On ◽  
Clinical Diagnostic ◽  
Diagnostic Applications ◽  
Nitrogen Doped Carbon

Nitrogen-doped carbon nanoparticle modulated turn-on fluorescent probes with excellent biocompatibility for rapid and selective detection of histidine were developed, and were applied for a histidine imaging assay in living cells, which presented great potential in the bio-labeling assay and clinical diagnostic applications.

scholarly journals Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4377 ◽  
Author(s):  
Michelle Bauer ◽  
Mia Strom ◽  
David S Hammond ◽  
Sarah Shigdar
Keyword(s):  
Clinical Diagnostics ◽  
Molecular Probe ◽  
Pathological Changes ◽  
Clinical Environment ◽  
Clinical Diagnostic ◽  
Diagnostic Applications

The mainstay of clinical diagnostics is the use of specialised ligands that can recognise specific biomarkers relating to pathological changes. While protein antibodies have been utilised in these assays for the last 40 years, they have proven to be unreliable due to a number of reasons. The search for the ‘perfect’ targeting ligand or molecular probe has been slow, though the description of chemical antibodies, also known as aptamers, nearly 30 years ago suggested a replacement reagent. However, uptake has been slow to progress into the clinical environment. In this review, we discuss the issues associated with antibodies and describe some of the applications of aptamers that have relevancy to the clinical diagnostic environment.

Sign in / Sign up

Export Citation Format

Share Document